Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phosphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.35 |
| ▸ | CA4 known ✓ | P22748 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CPT2 | P23786 | 1/20 | 0.33 |
| ▸ | CPT1A | P50416 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphine SCHEMBL27761535 | 0.93 | CA2 (0.40) | CA2CPT2CPT1AMEN1CYP1A2 | |
| SCHEMBL27969565 | 0.91 | CA2 (0.41) | CA2CPT2CPT1AMEN1CYP1A2 | |
| Phosphine SCHEMBL27661468 | 0.89 | ALOX15 (0.37) | ALOX15LMNASMN1; SMN2GRIK1 | |
| SCHEMBL4656229 | 0.88 | CPT2 (0.38) | CA2CPT2CPT1AMEN1CYP1A2 | |
| Potassium Ion SCHEMBL31723413 | 0.88 | CPT2 (0.38) | CA2CPT2CPT1AMEN1CYP1A2 | |
| SCHEMBL1824385 | 0.88 | ALOX15 (0.38) | ALOX15LMNASMN1; SMN2GRIK1 | |
| SCHEMBL4656227 | 0.86 | ALOX15 (0.37) | ALOX15LMNASMN1; SMN2GRIK1 | |
| Methane SCHEMBL28312792 | 0.86 | ALOX15 (0.37) | ALOX15LMNASMN1; SMN2GRIK1 | |
| SCHEMBL27856278 | 0.86 | ALOX15 (0.37) | ALOX15LMNASMN1; SMN2GRIK1 | |
| Butane SCHEMBL1173128 | 0.82 | GRIK1 (0.35) | ALOX15LMNASMN1; SMN2GRIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104736144-B | Efflux inhibitor compositions and methods of treatment using such compositions | 艾祖米科技有限公司 | 2019-02-01 | — | — | CN | disclosed |
| CN-107530410-A | Fusion proteins comprising modified alphavirus surface glycoproteins and tumor-associated antigens and methods thereof | 欧姆尼赛特有限公司 | 2018-01-02 | — | — | CN | disclosed |
| CN-102698287-B | The method for showing the promoter of endothelial cell specific and angiogenesis being adjusted using it | 脉管生物生长有限公司 | 2017-06-13 | — | — | CN | disclosed |
| CN-104854107-A | Pyrrolopyrimidine compounds as kinase inhibitors | PHARMACYCLICS INC | 2015-08-19 | — | — | CN | disclosed |