Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.35 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.32 |
| ▸ | CFD | P00746 | 4/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4089006 | 0.79 | CHRNB2 (0.35) | — | |
| SCHEMBL28041133 | 0.78 | HTR7 (0.37) | HTR7PNMTENPP2CSNK2A1CFD | |
| Fluoride Ion SCHEMBL5183964 | 0.76 | CHRNB2 (0.35) | — | |
| Bromide SCHEMBL27477694 | 0.76 | CHRNB2 (0.35) | — | |
| Hydrochloric Acid SCHEMBL28041353 | 0.75 | DPP4 (0.41) | PNMT | |
| Hydrochloric Acid SCHEMBL28041347 | 0.75 | KIF11 (0.42) | — | |
| Hydrochloric Acid SCHEMBL7058361 | 0.70 | HTR1A (0.37) | HTR7 | |
| Hydrochloric Acid SCHEMBL28041356 | 0.70 | RXRA (0.33) | — | |
| SCHEMBL27649924 | 0.68 | LOXL2 (0.58) | HTR7PNMTENPP2CSNK2A1CFD | |
| SCHEMBL28148805 | 0.68 | HTR7 (0.39) | HTR7PNMTENPP2CSNK2A1CFD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105026408-A | Metallocene compound, catalyst for olefin polymer, method for producing olefin polymer, and olefin polymer | JAPAN POLYETHYLENE CORP | 2015-11-04 | — | — | CN | disclosed |