Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Glycerin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 9/20 | 0.64 |
| ▸ | LPAR3 | Q9UBY5 | 9/20 | 0.64 |
| ▸ | LPAR2 | Q9HBW0 | 6/20 | 0.57 |
| ▸ | LPAR5 | Q9H1C0 | 6/20 | 0.56 |
| ▸ | LPAR6 | P43657 | 5/20 | 0.56 |
| ▸ | LPAR4 | Q99677 | 5/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | PRKCB | P05771 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | PRKCH | P24723 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.46 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1333581 | 0.89 | LPAR1 (0.69) | LPAR1LPAR3LPAR2LPAR5LPAR6 | |
| Glycerin SCHEMBL27652427 | 0.88 | LPAR3 (0.84) | LPAR1LPAR3LPAR2LPAR5LPAR6 | |
| Glycerin SCHEMBL28015462 | 0.88 | LPAR3 (0.84) | LPAR1LPAR3LPAR2LPAR5LPAR6 | |
| Glycerin SCHEMBL28236478 | 0.88 | LPAR5 (0.67) | LPAR1LPAR3LPAR2LPAR5LPAR6 | |
| Monoethanolamine SCHEMBL27910098 | 0.87 | LPAR1 (0.64) | LPAR1LPAR3LPAR2LPAR5LPAR6 | |
| Monoethanolamine SCHEMBL28048917 | 0.87 | LPAR1 (0.64) | LPAR1LPAR3LPAR2LPAR5LPAR6 | |
| Glycerin SCHEMBL28048895 | 0.86 | LPAR5 (0.64) | LPAR1LPAR3LPAR2LPAR5LPAR6 | |
| SCHEMBL10715915 | 0.86 | LPAR3 (0.61) | LPAR1LPAR3LPAR2LPAR5LPAR6 | |
| SCHEMBL31347450 | 0.84 | LPAR1 (0.68) | LPAR1LPAR3LPAR2LPAR5LPAR6 | |
| SCHEMBL31347443 | 0.84 | LPAR1 (0.68) | LPAR1LPAR3LPAR2LPAR5LPAR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102946865-B | Comprise the pharmaceutical emulsion composition of the low oil of progestogen | 博赏医药卢森堡责任有限公司 | 2016-06-22 | — | — | CN | disclosed |
| CN-103179951-B | Phospholipid depot | DR. REDDY'S LABORATORIES LTD. (IN) | 2016-01-20 | — | — | CN | disclosed |