Maackiain

Maackiain

SCHEMBL28064249

Oc1ccc2c(c1)OC[C@H]1c3cc4c(cc3O[C@@H]21)OCO4

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ MAOA P21397 2/20 1.00
▸ MAOB P27338 2/20 1.00
▸ CYP3A4 P08684 2/20 1.00
▸ MAPT P10636 1/20 0.67
▸ MAPK1 P28482 1/20 0.67
▸ TDP1 Q9NUW8 1/20 0.67
▸ PTPN1 P18031 3/20 0.55
▸ MGAM O43451 1/20 0.49
▸ ESR1 P03372 2/20 0.42
▸ ESR2 Q92731 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Maackiain SCHEMBL12810278 1.00 MAOA (1.00) MAOAMAOBCYP3A4MAPTMAPK1
Maackiain SCHEMBL29670858 1.00 MAOA (1.00) MAOAMAOBCYP3A4MAPTMAPK1
Demethylmedicarpin SCHEMBL29843376 0.88 MAOA (0.78) MAOAMAOBCYP3A4MAPTMAPK1
Medicarpin SCHEMBL2812444 0.88 MAOA (0.78) MAOAMAOBCYP3A4MAPTMAPK1
Demethylmedicarpin SCHEMBL31663447 0.88 MAOA (0.78) MAOAMAOBCYP3A4MAPTMAPK1
SCHEMBL8223903 0.83 MAOA (0.71) MAOAMAOBCYP3A4MAPTMAPK1
SCHEMBL12891393 0.83 MAOA (0.71) MAOAMAOBCYP3A4MAPTMAPK1
SCHEMBL12810804 0.83 MAOA (0.71) MAOAMAOBCYP3A4MAPTMAPK1
SCHEMBL232991 0.81 CYP3A4 (0.68) MAOAMAOBCYP3A4MAPTMAPK1
SCHEMBL19999737 0.81 MAOA (0.67) MAOAMAOBCYP3A4MAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3346842-B1 STABLE INOCULANT COMPOSITIONS AND METHODS FOR PRODUCING SAME NOVONESIS PLANT BIOSOLUTIONS AS (DK) 2026-03-25 — — EP claimed
US-12507703-B2 Methods, devices and compositions for preserving human milk THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2025-12-30 — — US disclosed
US-20250263774-A1 DISCOVERING NEW XENOBIOTIC SUBSTRATES OF AN UDP-GLYCOSYLTRANSFERASE WITH A HIGH-THROUGHPUT METHOD UNIV NORTH TEXAS (US) 2025-08-21 — — US disclosed
US-20250169516-A1 METHODS, DEVICES AND COMPOSITIONS FOR PRESERVING HUMAN MILK THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2025-05-29 — — US disclosed
US-12239142-B2 Methods, devices and compositions for preserving human milk THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2025-03-04 — — US disclosed
EP-4499222-A2 COMPOSITIONS AND METHODS FOR PROMOTING HAIR GROWTH Locus Solutions IPCO, LLC (US) 2025-02-05 — — EP disclosed
US-20240366488-A1 COMPOSITIONS AND METHODS FOR PROMOTING HAIR GROWTH U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL AGENT 2024-11-07 — — US disclosed
US-20240268402-A1 Methods, Devices and Compositions for Preserving Human Milk THE TRUSTEES OF PRINCETON UNIVERSITY (US) 2024-08-15 — — US disclosed
CN-117517550-A Chemical component detection method for expanded roots and non-expanded roots of millettia speciosa champ 中国热带农业科学院热带作物品种资源研究所 2024-02-06 — — CN disclosed
CN-117059172-A Method for analyzing action mechanism of ginseng for improving erection dysfunction 广州康兮乐健康科技有限公司 2023-11-14 — — CN disclosed
CN-116492330-A Application of flavonoid compound in preparation of drug-resistant plasmid conjugation transfer inhibition drug 扬州大学 2023-07-28 — — CN disclosed
CN-107880063-B Method for synthesizing subprostrate sophora 浙江工业大学 2019-05-28 — — CN disclosed
CN-107880063-A method for synthesizing subprostrate sophora 浙江工业大学 2018-04-06 — — CN disclosed
CN-106728297-A Treat pharmaceutical composition of vaginitis and preparation method thereof 济南昊雨青田医药技术有限公司 2017-05-31 — — CN disclosed
CN-106668239-A Pharmaceutical composition for preventing vitreous opacity 济南昊雨青田医药技术有限公司 2017-05-17 — — CN disclosed
CN-106539928-A One kind treats rheumatismal pharmaceutical composition and preparation method thereof 济南昊雨青田医药技术有限公司 2017-03-29 — — CN disclosed
CN-106138175-A The pharmaceutical composition for the treatment of Advanced Colon Cancer 济南星懿医药技术有限公司 2016-11-23 — — CN disclosed
CN-106109551-A A kind of pharmaceutical composition preventing and treating chloasma 济南星懿医药技术有限公司 2016-11-16 — — CN disclosed
CN-105596749-A Pharmaceutical composition for treating depression and preparing method thereof JINAN XINGYI MED TECH CO LTD 2016-05-25 — — CN disclosed
CN-105535060-A Medicine composition for preventing and treating coronary heart disease JINAN XINGYI MED TECH CO LTD 2016-05-04 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12507703-B2 Methods, devices and compositions for preserving human milk LPL, CEL, LPO MAOA 471/4885MAOB 293/4885CYP3A4 1678/4885
US-20240366488-A1 COMPOSITIONS AND METHODS FOR PROMOTING HAIR GROWTH NGF, FGF1, NTRK2 MAOA 236/4885MAOB 253/4885CYP3A4 4337/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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