SCHEMBL28080840

SCHEMBL28080840

O=CC(=O)c1c(-c2ccccc2)c(-c2ccccc2)cn1CCCc1ccccc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
COMT P21964 1/20 0.41
ADRA1D P25100 1/20 0.41
GPR52 Q9Y2T5 2/20 0.39
CHRNB2 P17787 6/20 0.37
CHRNA4 P43681 6/20 0.37
CHRNB4 P30926 5/20 0.37
CHRNA3 P32297 5/20 0.37
MAPK8 P45983 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
HDAC3 O15379 1/20 0.36
MAPK1 P28482 1/20 0.36
ADRA1A P35348 1/20 0.36
HDAC4 P56524 1/20 0.36
SLC6A3 Q01959 1/20 0.36
HDAC1 Q13547 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC10 Q969S8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28831833 0.92 GPR52 (0.40) ADRA1DGPR52MAPK8TDP1HDAC3
Benzene SCHEMBL28080834 0.86 CNR2 (0.43)
SCHEMBL28080836 0.84 F2RL3 (0.39) ADRA1DGPR52MAPK8
SCHEMBL28080837 0.81 TEAD3 (0.40) HDAC3HDAC4HDAC1SMN1; SMN2HDAC7
SCHEMBL28080903 0.77 ALDH1A1 (0.43) ADRA1DSMN1; SMN2
SCHEMBL28080894 0.76 ALDH1A1 (0.47) ADRA1DTDP1L3MBTL1SMN1; SMN2SIGMAR1
SCHEMBL28080900 0.74 LMNA (0.39) TDP1HDAC3HDAC4HDAC1SMN1; SMN2
SCHEMBL28080891 0.73 ALDH1A1 (0.44) ADRA1DL3MBTL1SMN1; SMN2MAPT
SCHEMBL28080843 0.73 CYP11B1 (0.44) HDAC8HDAC6MAPT
SCHEMBL28080828 0.73 CCR2 (0.46) SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103804108-B A kind of method preparing primary amine 沈阳药科大学 2016-08-03 CN disclosed