Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2940976 | 1.00 | ALDH1A1 (0.65) | ALDH1A1TSHRCYP2A6MAPTRAB9A | |
| SCHEMBL31380601 | 0.90 | ALDH1A1 (0.53) | ALDH1A1TSHRCYP2A6MAPTRAB9A | |
| SCHEMBL31380626 | 0.90 | ALDH1A1 (0.53) | ALDH1A1TSHRCYP2A6MAPTRAB9A | |
| SCHEMBL31380620 | 0.90 | ALDH1A1 (0.53) | ALDH1A1TSHRCYP2A6MAPTRAB9A | |
| SCHEMBL31380590 | 0.90 | ALDH1A1 (0.53) | ALDH1A1TSHRCYP2A6MAPTRAB9A | |
| SCHEMBL30297379 | 0.83 | MAPT (0.58) | ALDH1A1TSHRCYP2A6MAPTRAB9A | |
| SCHEMBL30297389 | 0.83 | MAPT (0.58) | ALDH1A1TSHRCYP2A6MAPTRAB9A | |
| SCHEMBL28141273 | 0.82 | ALDH1A1 (0.65) | ALDH1A1TSHRMAPTPTGS2PKM | |
| SCHEMBL31380594 | 0.81 | MAPT (0.49) | ALDH1A1TSHRCYP2A6MAPTRAB9A | |
| SCHEMBL13726421 | 0.81 | MAPT (0.49) | ALDH1A1TSHRCYP2A6MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200390754-A1 | METHODS OF ADMINISTERING TOLPERISONE | NEURANA PHARMACEUTICALS, INC. | 2020-12-17 | — | — | US | claimed |
| CN-111886007-A | Methods of administering tolperisone | 纽兰娜制药股份有限公司 | 2020-11-03 | — | — | CN | claimed |
| EP-3709989-A1 | METHODS OF ADMINISTERING TOLPERISONE | Neurana Pharmaceuticals, Inc. (US) | 2020-09-23 | — | — | EP | claimed |
| US-20180344717-A1 | COMPOSITIONS OF TOLPERISONE | Sanochemia Pharmazeutika GmbH (AT) | 2018-12-06 | — | — | US | claimed |
| US-20170239228-A1 | COMPOSITIONS OF TOLPERISONE | Sanochemia Pharmazeutika GmbH (AT) | 2017-08-24 | — | — | US | claimed |
| US-9675598-B2 | Compositions of tolperisone | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2017-06-13 | — | — | US | claimed |
| US-9662317-B2 | Methods of administering tolperisone for therapeutic purposes | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2017-05-30 | — | — | US | claimed |
| US-20160367540-A1 | COMPOSITIONS OF TOLPERISONE | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2016-12-22 | — | — | US | claimed |
| US-20160220549-A1 | METHODS OF ADMINISTERING TOLPERISONE FOR THERAPEUTIC PURPOSES | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2016-08-04 | — | — | US | claimed |
| EP-2150540-B1 | METHOD FOR THE PRODUCTION OF HIGHLY PURE 2,4'-DIMETHYL-3-PIPERIDINO-PROPIOPHENONE (TOLPERISONE), PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND AGENT FORMULATIONS CONTAINING TOLPERISONE | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2016-06-01 | — | — | EP | claimed |
| US-9315480-B2 | Compositions of tolperisone | SANOCHEMIA PHARMAZEUTIKA AG (AU) | 2016-04-19 | — | — | US | claimed |
| US-20100150995-A1 | PROCESS FOR THE PRODUCTION OF HIGH-PURITY 2,4'-DIMETHYL-3-PIPERIDINO-PROPIOPHENONE (TOLPERISONE), PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THE LATTER, AS WELL AS ACTIVE INGREDIENT FORMULATIONS THAT CONTAIN TOLPERISONE | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2010-06-17 | — | — | US | claimed |
| EP-2150540-A2 | METHOD FOR THE PRODUCTION OF HIGHLY PURE 2,4'-DIMETHYL-3-PIPERIDINO-PROPIOPHENONE (TOLPERISONE), PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND AGENT FORMULATIONS CONTAINING TOLPERISONE | Sanochemia Pharmazeutika AG (AT) | 2010-02-10 | — | — | EP | claimed |
| WO-2008131469-A2 | METHOD FOR THE PRODUCTION OF HIGHLY PURE 2,4'-DIMETHYL-3-PIPERIDINO-PROPIOPHENONE (TOLPERISONE), PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND AGENT FORMULATIONS CONTAINING TOLPERISONE | SANOCHEMIA PHARMAZEUTIKA AG (AT) | 2008-11-06 | — | — | WO | claimed |
| CN-112154193-B | Downhole methods using acid compositions containing corrosion inhibitors | 液体能源集团有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-110845443-B | Method for preparing high-purity tolperisone hydrochloride | 嘉实（湖南）医药科技有限公司 | 2023-09-05 | — | — | CN | disclosed |
| CN-110845443-A | Method for preparing high-purity tolperisone hydrochloride | 嘉实（湖南）医药科技有限公司 | 2020-02-28 | — | — | CN | disclosed |
| US-4283534-A | Reductive alkylation of nitrogen heterocycles | BASF AKTIENGESELLSCHAFT (DE) | 1981-08-11 | — | — | US | disclosed |
| EP-0017893-A1 | Process for the preparation of heterocyclic tertiary aralkyl amines | BASF Aktiengesellschaft (DE) | 1980-10-29 | — | — | EP | disclosed |
| US-4009170-A | 1-Ethoxy-3,4-dihydroisoquindines | STERLING DRUG INC. (US) | 1977-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200390754-A1 | METHODS OF ADMINISTERING TOLPERISONE | ACHE, THOP1, CHAT | ALDH1A1 2761/4885TSHR 247/4885CYP2A6 266/4885 |
| US-20100150995-A1 | PROCESS FOR THE PRODUCTION OF HIGH-PURITY 2,4'-DIMETHYL-3-PIPERIDINO-PROPIOPHENONE (TOLPERISONE), PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THE LATTER, AS WELL AS ACTIVE INGREDIENT FORMULATIONS THAT CONTAIN TOLPERISONE | MMP17, MMP25, MMP1 | ALDH1A1 385/4885TSHR 1852/4885CYP2A6 164/4885 |
| US-20160220549-A1 | METHODS OF ADMINISTERING TOLPERISONE FOR THERAPEUTIC PURPOSES | THOP1, ADAMTS4, ADAMTS5 | ALDH1A1 455/4885TSHR 801/4885CYP2A6 311/4885 |
| US-20170239228-A1 | COMPOSITIONS OF TOLPERISONE | ADAMTS4, ADAMTS1, ADAMTS5 | ALDH1A1 272/4885TSHR 807/4885CYP2A6 106/4885 |
| US-20160367540-A1 | COMPOSITIONS OF TOLPERISONE | ADAMTS4, ADAMTS1, ADAMTS5 | ALDH1A1 272/4885TSHR 807/4885CYP2A6 106/4885 |
| US-20180344717-A1 | COMPOSITIONS OF TOLPERISONE | ADAMTS4, ADAMTS1, ADAMTS5 | ALDH1A1 272/4885TSHR 807/4885CYP2A6 106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.