Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28158503 | 0.81 | TERT (0.35) | TSHRNPSR1ALDH1A1MAPTHTT | |
| SCHEMBL27712033 | 0.80 | MAPT (0.38) | NPSR1ALDH1A1MAPTHTTSMN1; SMN2 | |
| SCHEMBL27369841 | 0.80 | ALDH1A1 (0.43) | NPC1ALDH1A1MAPTHTTSMN1; SMN2 | |
| SCHEMBL25178380 | 0.80 | MAPT (0.48) | TSHRCYP3A4ALDH1A1MAPTHTT | |
| SCHEMBL27692022 | 0.79 | PRKCZ (0.45) | CYP2C19ALDH1A1HTTSMN1; SMN2KMT2A | |
| SCHEMBL27800063 | 0.77 | ALDH1A1 (0.30) | ALDH1A1MAPTHTTSMN1; SMN2 | |
| SCHEMBL23438273 | 0.76 | NOTUM (0.39) | TSHRNOTUMCYP3A4CYP2C19NPSR1 | |
| SCHEMBL27995307 | 0.70 | TERT (0.36) | NPSR1SMN1; SMN2KMT2AMEN1HPGD | |
| SCHEMBL27732171 | 0.69 | TERT (0.40) | TSHRALDH1A1MAPTHTTSMN1; SMN2 | |
| SCHEMBL27447779 | 0.69 | CD274 (0.46) | NPSR1NPC1ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113929626-A | Method for synthesizing eltrombopag | 苏州特瑞药业有限公司 | 2022-01-14 | — | — | CN | claimed |
| CN-107870217-A | Detection method of the eltrombopag olamine intermediate about material and the impurity reference substance for this method | 齐鲁制药有限公司 | 2018-04-03 | — | — | CN | claimed |
| CN-115322110-B | Method for synthesizing eltrombopag intermediate 3 '-amino-2' -hydroxybiphenyl-3-carboxylic acid | 常熟理工学院 | 2024-03-19 | — | — | CN | disclosed |
| CN-107021928-B | Eltrombopag intermediate, preparation method and application thereof | 常州制药厂有限公司 | 2022-11-18 | — | — | CN | disclosed |
| CN-115322110-A | Method for synthesizing eltrombopag intermediate 3 '-amino-2' -hydroxybiphenyl-3-carboxylic acid | 常熟理工学院 | 2022-11-11 | — | — | CN | disclosed |
| CN-107870217-B | Detection method of eltrombopag intermediate I related substances | 齐鲁制药有限公司 | 2022-03-04 | — | — | CN | disclosed |
| CN-113929626-A | Method for synthesizing eltrombopag | 苏州特瑞药业有限公司 | 2022-01-14 | — | — | CN | disclosed |
| CN-113929626-A | Method for synthesizing eltrombopag | 苏州特瑞药业有限公司 | 2022-01-14 | — | — | CN | disclosed |
| CN-111440181-A | Dipyrazolo seven-membered oxygen heterocyclic compound containing quinoline structure and synthetic method thereof | 烟台大学 | 2020-07-24 | — | — | CN | disclosed |
| CN-108101845-B | Preparation method of eltrombopag | 苏州科伦药物研究有限公司 | 2020-05-15 | — | — | CN | disclosed |
| CN-107870217-A | Detection method of the eltrombopag olamine intermediate about material and the impurity reference substance for this method | 齐鲁制药有限公司 | 2018-04-03 | — | — | CN | disclosed |