Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 5/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | LDHA | P00338 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | LDHB | P07195 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
| ▸ | BCL2 | P10415 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428218 | 0.80 | MEN1 (0.36) | MEN1ALDH1A1KMT2ATDP1 | |
| SCHEMBL5379601 | 0.77 | ALDH1A1 (0.39) | KDM4EMEN1NPC1ALDH1A1CYP1A2 | |
| SCHEMBL28985344 | 0.77 | HPGD (0.40) | AKR1B1ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL1620823 | 0.75 | ALDH1A3 (0.34) | KDM4ENPSR1 | |
| SCHEMBL18428478 | 0.75 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL282196 | 0.75 | ALDH1A1 (0.41) | ALDH1A1LMNAMAPTHPGD | |
| SCHEMBL19265771 | 0.75 | ALDH1A3 (0.48) | AKR1B1ALBKDM4EMEN1NPC1 | |
| SCHEMBL282712 | 0.75 | ALDH1A1 (0.41) | ALDH1A1TP53POLBCYP3A4TDP1 | |
| SCHEMBL1251338 | 0.73 | CA12 (0.40) | — | |
| SCHEMBL1619909 | 0.71 | CYP1A1 (0.44) | KDM4EMEN1NPC1USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115819288-B | Nitrile oxide, difunctional nitrile oxide and preparation method thereof | 西安近代化学研究所 | 2024-05-28 | — | — | CN | claimed |
| CN-115819288-A | Nitrile oxide, bifunctional nitrile oxide and preparation method thereof | 西安近代化学研究所 | 2023-03-21 | — | — | CN | claimed |
| EP-4662219-A2 | PRODRUGS OF THYROID HORMONE ANALOGS, METHODS OF MAKING AND METHODS OF USING THEREOF | ASCLETIS PHARMA (CHINA) CO., LIMITED (HK) | 2025-12-17 | — | — | EP | disclosed |
| EP-4644357-A1 | COMPOUND USEFUL AS THYROID HORMONE RECEPTOR B-SELECTIVE THYROID HORMONE ANALOG | NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM (JP) | 2025-11-05 | — | — | EP | disclosed |
| US-20240294561-A1 | Prodrugs of Thyroid Hormone Analogs, Methods of Making and Methods of Using Thereof | ASCLETIS PHARMA (CHINA) CO., LIMITED (CN) | 2024-09-05 | — | — | US | disclosed |
| WO-2024167961-A2 | PRODRUGS OF THYROID HORMONE ANALOGS, METHODS OF MAKING AND METHODS OF USING THEREOF | GANNEX, LLC (US) | 2024-08-15 | — | — | WO | disclosed |
| WO-2024143235-A1 | COMPOUND USEFUL AS THYROID HORMONE RECEPTOR β-SELECTIVE THYROID HORMONE ANALOG | 国立大学法人東海国立大学機構 | 2024-07-04 | — | — | WO | disclosed |
| CN-115819288-B | Nitrile oxide, difunctional nitrile oxide and preparation method thereof | 西安近代化学研究所 | 2024-05-28 | — | — | CN | disclosed |
| CN-112300211-B | Compound serving as thyroid hormone beta receptor agonist and application thereof | 广东东阳光药业股份有限公司 | 2023-12-08 | — | — | CN | disclosed |
| US-20230339993-A1 | PREPARATION METHOD OF A CYCLIC PHOSPHONATE COMPOUND | GANNEX PHARMA CO., LTD. (CN) | 2023-10-26 | — | — | US | disclosed |
| US-11725019-B2 | Preparation method of a cyclic phosphonate compound | GANNEX PHARMA CO LTD. (CN) | 2023-08-15 | — | — | US | disclosed |
| EP-1689383-A4 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS INC (US) | 2009-02-18 | — | — | EP | disclosed |
| US-20090028925-A1 | Novel Phosphinic Acid-Containing Thyromimetics | METABASIS THERAPEUTICS, INC. | 2009-01-29 | — | — | US | disclosed |
| EP-1891080-A2 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | Metabasis Therapeutics, Inc. (US) | 2008-02-27 | — | — | EP | disclosed |
| EP-1890768-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | Metabasis Therapeutics, Inc. (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006128056-A2 | NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |
| WO-2006128055-A2 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |
| EP-1689383-A2 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | Metabasis Therapeutics, Inc. (US) | 2006-08-16 | — | — | EP | disclosed |
| US-20060046980-A1 | Novel phosphorus-containing thyromimetics | METABASIS THERAPEUTICS, INC. | 2006-03-02 | — | — | US | disclosed |
| WO-2005051298-A2 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2005-06-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240294561-A1 | Prodrugs of Thyroid Hormone Analogs, Methods of Making and Methods of Using Thereof | THRB, THRA, TSHR | AKR1B1 397/4885ALB 4425/4885KDM4E 3558/4885 |
| US-11725019-B2 | Preparation method of a cyclic phosphonate compound | PHOSPHO1, PPIP5K2, PNKP | AKR1B1 1355/4885ALB 2930/4885KDM4E 4335/4885 |
| US-20060046980-A1 | Novel phosphorus-containing thyromimetics | PYGL, THRA, THOP1 | AKR1B1 1452/4885ALB 1996/4885KDM4E 4102/4885 |
| US-20230339993-A1 | PREPARATION METHOD OF A CYCLIC PHOSPHONATE COMPOUND | PHOSPHO1, PPIP5K2, PNKP | AKR1B1 1355/4885ALB 2930/4885KDM4E 4335/4885 |
| US-20090028925-A1 | Novel Phosphinic Acid-Containing Thyromimetics | PYGL, PHOSPHO1, LIPE | AKR1B1 1741/4885ALB 1305/4885KDM4E 4083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.