Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2838800 | 0.87 | NPC1 (0.42) | ALDH1A1POLBMAPTGAALMNA | |
| SCHEMBL5365358 | 0.74 | RXRA (0.45) | ALDH1A1L3MBTL1 | |
| SCHEMBL2840999 | 0.72 | KMT2A (0.43) | ALDH1A1POLBMAPTABL1RIN1 | |
| SCHEMBL21767046 | 0.69 | LMNA (0.43) | ALDH1A1POLBMAPTABL1RIN1 | |
| SCHEMBL2835727 | 0.69 | L3MBTL1 (0.42) | ALDH1A1POLBMAPTABL1RIN1 | |
| SCHEMBL2994358 | 0.67 | SMN1; SMN2 (0.42) | ALDH1A1POLBMAPTABL1RIN1 | |
| SCHEMBL2994354 | 0.67 | SMN1; SMN2 (0.42) | ALDH1A1POLBMAPTABL1RIN1 | |
| SCHEMBL2994360 | 0.67 | SMN1; SMN2 (0.42) | ALDH1A1POLBMAPTABL1RIN1 | |
| SCHEMBL2835764 | 0.66 | GAA (0.40) | ALDH1A1MAPTGAALMNAMEN1 | |
| SCHEMBL13077758 | 0.64 | ABHD6 (0.63) | ALDH1A1POLBMAPTGAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8217031-B2 | Heteroaryl derivatives | NIPPON SHINYAKU CO., LTD. (JP) | 2012-07-10 | — | — | US | disclosed |
| US-20100048537-A1 | HETEROARYL DERIVATIVES | NIPPON SHINYAKU CO., LTD. (JP) | 2010-02-25 | — | — | US | disclosed |
| EP-2141168-A1 | HETEROARYL DERIVATIVES | Nippon Shinyaku Co., Ltd. (JP) | 2010-01-06 | — | — | EP | disclosed |
| US-4636510-A | 4-phenyl-tetrahydro-furano-pyridines and anti-depressant pharmaceutical compositions containing same | BOEHRINGER INGELHEIM KG (DE) | 1987-01-13 | — | — | US | disclosed |
| EP-0123998-A2 | 4-Phenyl-tetrahydro-furano-pyridines, process for their preparation and pharmaceutical compositions | BOEHRINGER INGELHEIM KG (DE) | 1984-11-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048537-A1 | HETEROARYL DERIVATIVES | OPRD1, OPRM1, OPRK1 | ALDH1A1 66/4885POLB 3087/4885DPP4 2531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.