SCHEMBL28394

SCHEMBL28394

CN(O)C(=O)OC(C)(C)C

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 2/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC2 Q92769 1/20 0.38
DGAT1 O75907 1/20 0.37
CA14 Q9ULX7 2/20 0.34
CTSD P07339 1/20 0.32
CTSL P07711 1/20 0.32
CTSB P07858 1/20 0.32
CTSS P25774 1/20 0.32
ASGR1 P07306 1/20 0.31
NFKB1 P19838 1/20 0.31
NFKB2 Q00653 1/20 0.31
RELA Q04206 1/20 0.31
CA12 O43570 1/20 0.31
CA1 P00915 1/20 0.31
CA7 P43166 1/20 0.31
PAX8 Q06710 1/20 0.30
USP2 O75604 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL30569791 0.97 HDAC6 (0.37) HDAC6HDAC1HDAC2DGAT1CA14
SCHEMBL761358 0.80 HDAC6 (0.39) HDAC6HDAC1HDAC2DGAT1CA14
SCHEMBL8737769 0.80 HDAC6 (0.39) HDAC6HDAC1HDAC2DGAT1CA14
SCHEMBL3716921 0.80 HDAC6 (0.39) HDAC6HDAC1HDAC2DGAT1CA14
SCHEMBL12096699 0.76 HDAC6 (0.37) HDAC6HDAC1HDAC2DGAT1CA14
SCHEMBL206709 0.76 HDAC6 (0.37) HDAC6HDAC1HDAC2DGAT1CA14
SCHEMBL3266659 0.76 CTSD (0.37) HDAC6HDAC1HDAC2DGAT1CA14
SCHEMBL21278220 0.76 HDAC6 (0.37) HDAC6HDAC1HDAC2DGAT1CA14
SCHEMBL13286079 0.76 HDAC6 (0.37) HDAC6HDAC1HDAC2DGAT1CA14
SCHEMBL432112 0.76 HDAC6 (0.37) HDAC6HDAC1HDAC2DGAT1CA14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 153 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119546611-A Preparation process and intermediate of rui Lu Geli 台湾神隆股份有限公司 2025-02-28 CN claimed
US-20230357267-A1 PROCESS FOR PREPARING RELUGOLIX AND INTERMEDIATES THEREOF SCINOPHARM TAIWAN, LTD. (TW) 2023-11-09 US claimed
US-12454547-B2 Steroidal compositions and methods of treating lipogenic cancers Asteroid Therapeutics (US) 2025-10-28 US disclosed
US-12403144-B2 HECT E3 ligase inhibitors and uses thereof IFOM —FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE (IT) 2025-09-02 US disclosed
US-20250235547-A1 ANTIBODY-DRUG CONJUGATE UBE CORPORATION (JP) 2025-07-24 US disclosed
WO-2025128873-A1 HETEROCYCLIC PYRIDINONE COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS AND METHODS OF USE VIGIL NEUROSCIENCE, INC. (US) 2025-06-19 WO disclosed
US-20250170267-A1 ANTIBODY-DRUG CONJUGATE PRECURSOR AND INTERMEDIATE FOR SYNTHESIS THEREOF UBE CORPORATION (JP) 2025-05-29 US disclosed
EP-4541796-A1 EXATECAN DERIVATIVES AND USE THEREOF Hangzhou Adcoris Biopharma Co., Ltd (CN) 2025-04-23 EP disclosed
WO-2025056066-A1 EXATECAN HYDROXYLAMINE DERIVATIVE AND USE THEREOF 杭州爱科瑞思生物医药有限公司 2025-03-20 WO disclosed
CN-119546611-A Preparation process and intermediate of rui Lu Geli 台湾神隆股份有限公司 2025-02-28 CN disclosed
US-20250032623-A1 HETEROBIFUNCTIONAL COMPOUNDS AND THEIR USE IN TREATING DISEASE HALDA THERAPEUTICS OPCO, INC. 2025-01-30 US disclosed
US-20080200445-A1 Use in treatment of cardiovascular diseases, cognitive and neurodegenerative diseases, inhibitors of Human Immunodeficiency Virus, plasmepsins, cathepsin D and protozoal enzymes; 4-imidazolidinone, 5-(3'-chloro[1,1'-biphenyl]-3-yl)-5-cyclopropyl-2-imino-3-(2,2,2-trifluoroethyl)-, for example SCHERING CORPORATION & PHARMACOPEIA DRUG DISCOVERY, INC. 2008-08-21 US disclosed
WO-2008098056-A2 HIGH RELAXIVITY CHELATES EPIX PHARMACEUTICALS, INC. (US) 2008-08-14 WO disclosed
WO-2008083191-A2 RADIOFLUORINATION METHODS GE HEALTHCARE AS (NO) 2008-07-10 WO disclosed
US-20070281865-A1 MULTI-FUNCTIONAL SPACER FOR GLYCANS SCRIPPS RESEARCH INSTITUTE, THE 2007-12-06 US disclosed
US-20070281865-A1 MULTI-FUNCTIONAL SPACER FOR GLYCANS SCRIPPS RESEARCH INSTITUTE, THE 2007-12-06 US disclosed
EP-1838304-A2 HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS SCHERING CORPORATION (US) 2007-10-03 EP disclosed
WO-2006065277-A2 HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS SCHERING CORPORATION (US) 2006-06-22 WO disclosed
US-20060111370-A1 Heterocyclic aspartyl protease inhibitors SCHERING CORPORATION 2006-05-25 US disclosed
US-4091105-A 2-Imino-3-aminothiazolidines and indoleamine-N-methyltransferase inhibition MERCK & CO., INC. (US) 1978-05-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12454547-B2 Steroidal compositions and methods of treating lipogenic cancers SREBF1, SREBF2, NR1H3 HDAC6 3664/4885HDAC1 849/4885HDAC2 1199/4885
US-20060111370-A1 Heterocyclic aspartyl protease inhibitors CHRM1, CHRM2, PRSS1 HDAC6 2138/4885HDAC1 969/4885HDAC2 1666/4885
US-12403144-B2 HECT E3 ligase inhibitors and uses thereof NEDD4, ITCH, UBE3A HDAC6 453/4885HDAC1 929/4885HDAC2 2791/4885
US-20230357267-A1 PROCESS FOR PREPARING RELUGOLIX AND INTERMEDIATES THEREOF PRMT8, PRMT7, PRMT1 HDAC6 924/4885HDAC1 841/4885HDAC2 1873/4885
US-20080200445-A1 Use in treatment of cardiovascular diseases, cognitive and neurodegenerative diseases, inhibitors of Human Immunodeficiency Virus, plasmepsins, cathepsin D and protozoal enzymes; 4-imidazolidinone, 5-(3'-chloro[1,1'-biphenyl]-3-yl)-5-cyclopropyl-2-imino-3-(2,2,2-trifluoroethyl)-, for example CTSZ, CTSL, PRSS1 HDAC6 1566/4885HDAC1 1455/4885HDAC2 2015/4885
US-20250235547-A1 ANTIBODY-DRUG CONJUGATE LDHB, LDHA, DLST HDAC6 160/4885HDAC1 566/4885HDAC2 972/4885
US-20250032623-A1 HETEROBIFUNCTIONAL COMPOUNDS AND THEIR USE IN TREATING DISEASE AURKB, CDK9, AURKA HDAC6 104/4885HDAC1 94/4885HDAC2 329/4885
US-20250170267-A1 ANTIBODY-DRUG CONJUGATE PRECURSOR AND INTERMEDIATE FOR SYNTHESIS THEREOF DLST, LANCL1, DDOST HDAC6 114/4885HDAC1 508/4885HDAC2 1508/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.