SCHEMBL284737

SCHEMBL284737

C[C@H]1O[C@@H](n2cnc3c(N)ncnc32)C[C@@H]1O

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ AHCY P23526 7/20 0.59
▸ ADA P00813 1/20 0.55
▸ STING1 Q86WV6 1/20 0.55
▸ TP53 P04637 1/20 0.54
▸ CYP2C9 P11712 1/20 0.54
▸ NFKB1 P19838 1/20 0.54
▸ MAPK1 P28482 1/20 0.54
▸ HSD17B10 Q99714 1/20 0.54
▸ MEN1 O00255 1/20 0.54
▸ ALDH1A1 P00352 1/20 0.54
▸ APEX1 P27695 1/20 0.54
▸ PI4KA P42356 1/20 0.54
▸ BLM P54132 1/20 0.54
▸ KMT2A Q03164 1/20 0.54
▸ ADCY1 Q08828 1/20 0.54
▸ PI4K2B Q8TCG2 1/20 0.54
▸ PI4K2A Q9BTU6 1/20 0.54
▸ PI4KB Q9UBF8 1/20 0.54
▸ POLB P06746 1/20 0.54
▸ ENPP1 P22413 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5962598 1.00 AHCY (0.59) AHCYADASTING1TP53CYP2C9
SCHEMBL20794222 1.00 AHCY (0.59) AHCYADASTING1TP53CYP2C9
SCHEMBL29362124 1.00 AHCY (0.59) AHCYADASTING1TP53CYP2C9
SCHEMBL10015774 1.00 AHCY (0.59) AHCYADASTING1TP53CYP2C9
SCHEMBL896624 1.00 AHCY (0.59) AHCYADASTING1TP53CYP2C9
SCHEMBL23396436 1.00 AHCY (0.59) AHCYADASTING1TP53CYP2C9
SCHEMBL5962596 1.00 AHCY (0.59) AHCYADASTING1TP53CYP2C9
SCHEMBL13986298 0.87 AHCY (0.57) AHCYADASTING1TP53CYP2C9
SCHEMBL17833855 0.87 AHCY (0.62) AHCYADASTING1TP53CYP2C9
SCHEMBL13986311 0.87 AHCY (0.57) AHCYADASTING1TP53CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 287 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12268901-B2 Targeting cell tropism receptors to inhibit cytomegalovirus infection UNIVERSITY OF MASSACHUSETTS (US) 2025-04-08 — — US claimed
CN-118186099-A Method for jointly verifying dopamine signaling pathway by using nematodes and human cells 上海大学 2024-06-14 — — CN claimed
US-20230034732-A1 TARGETING CELL TROPISM RECEPTORS TO INHIBIT CYTOMEGALOVIRUS INFECTION UNIVERSITY OF MASSACHUSETTS 2023-02-02 — — US claimed
US-20210290623-A1 METHODS FOR TREATING OR PREVENTING CARDIOVASCULAR DISORDERS AND LOWERING RISK OF CARDIOVASCULAR EVENTS DALCOR PHARMA UK LTD., LEATHERHEAD, ZUG BRANCH (CH) 2021-09-23 — — US claimed
EP-3833336-A1 METHODS FOR DELAYING OCCURRENCE OF NEW-ONSET TYPE 2 DIABETES AND FOR SLOWING PROGRESSION OF AND TREATING TYPE 2 DIABETES DalCor Pharma UK Ltd Leatherhead, Zug Branch (CH) 2021-06-16 — — EP claimed
CN-112888432-A Methods for delaying the onset of new onset type 2 diabetes and for slowing the progression of type 2 diabetes and treating type 2 diabetes 英国达科(莱得海德)制药有限公司-楚歌分公司 2021-06-01 — — CN claimed
US-10912786-B2 Silyl monomers capable of multimerizing in an aqueous solution, and methods of using same CORNELL UNIVERSITY (US) 2021-02-09 — — US claimed
US-10898516-B2 Compositions and methods of treating diabetic retinopathy CASE WESTERN UNIVERSITY (US) 2021-01-26 — — US claimed
US-20200376077-A1 Targeting Cell Tropism Receptors to Inhibit Cytomegalovirus Infection UNIVERSITY OF MASSACHUSETTS 2020-12-03 — — US claimed
US-20200276312-A1 Elimination of chronic pain by chronic activation of adenosine receptor type A1 in peripheral sensory neurons UNIV ROCHESTER (US) 2020-09-03 — — US claimed
US-20060099568-A1 Signals and molecular species involved in senescence SEOUL NATIONAL UNIVERSITY INDUSTRY FOUNDATION (KR) 2006-05-11 — — US claimed
WO-2005092306-A1 METHODS AND COMPOSITIONS FOR MODULATING OPIOID TOLERANCE AND CHRONIC PAIN THE GENERAL HOSPITAL CORPORATION (US) 2005-10-06 — — WO claimed
EP-1557461-A1 COMPOSITION FOR CULTURING MULTIPOTENT STEM CELLS AND UTILIZATION OF THE SAME RIKEN (JP) 2005-07-27 — — EP claimed
EP-1542687-A1 SMALL ORGANIC MOLECULES THAT INCREASE THE ACTIVITY OF GELATINASE A IN OCULAR CELLS BAUSCH & LOMB INCORPORATED (US) 2005-06-22 — — EP claimed
WO-2004028538-A1 SMALL ORGANIC MOLECULES THAT INCREASE THE ACTIVITY OF GELATINASE A IN OCULAR CELLS BAUSCH & LOMB INCORPORATED (US) 2004-04-08 — — WO claimed
US-20040068017-A1 Small organic molecules that increase the activity of Gelatinase A in ocular cells BAUSCH & LOMB INCORPORATED 2004-04-08 — — US claimed
WO-2004006832-A2 METHODS AND COMPOUNDS FOR REDUCING BIOFILM FORMATION ROMEO TONY (US) 2004-01-22 — — WO claimed
US-20040009927-A1 Methods and compounds for reducing biofilm formulation UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTRE AT FORT WORTH 2004-01-15 — — US claimed
WO-2003104482-A1 SIGNALS AND MOLECULAR SPECIES INVOLVED IN SENESCENCE METABOLIC ENGINEERING LABORATORIES CO., LTD. (KR) 2003-12-18 — — WO claimed
US-6429208-B1 ADMINISTERING 2',5'-DIDEOXYADENOSINE TO INHIBIT PROTEIN KINASE A/CYCLIC ADENOSINE MONOPHOSPHATE PATHWAY; REVERSES EFFECTS OF HIV INFECTION; ALLOWS FOR LYMPHOCYTE PROLIFERATION REGENTS OF THE UNIVERSITY OF CALIFORNIA 2002-08-06 — — US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040068017-A1 Small organic molecules that increase the activity of Gelatinase A in ocular cells MMP1, MMP3, MMP10 AHCY 4194/4885ADA 4178/4885STING1 4297/4885
US-10912786-B2 Silyl monomers capable of multimerizing in an aqueous solution, and methods of using same STIM1, STAMBP, ILK AHCY 1970/4885ADA 4822/4885STING1 3739/4885
US-20210290623-A1 METHODS FOR TREATING OR PREVENTING CARDIOVASCULAR DISORDERS AND LOWERING RISK OF CARDIOVASCULAR EVENTS HMGCR, PCSK9, FABP3 AHCY 388/4885ADA 348/4885STING1 3142/4885
US-20200276312-A1 Elimination of chronic pain by chronic activation of adenosine receptor type A1 in peripheral sensory neurons P2RX3, P2RX1, P2RX2 AHCY 1773/4885ADA 397/4885STING1 928/4885
US-10898516-B2 Compositions and methods of treating diabetic retinopathy GPR119, ARRB1, GRK1 AHCY 2493/4885ADA 2606/4885STING1 1387/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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