Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 2/20 | 1.00 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.70 |
| ▸ | CYP2C8 | P10632 | 4/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.70 |
| ▸ | CYP2B6 | P20813 | 4/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.70 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.61 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.61 |
| ▸ | LTA4H | P09960 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrocurcumin SCHEMBL29370299 | 1.00 | ALOX5 (1.00) | ALOX5OR51E2CYP3A4CYP2C8CYP2C9 | |
| Tetrahydrocurcumin SCHEMBL29372158 | 1.00 | ALOX5 (1.00) | ALOX5OR51E2CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL10307533 | 0.95 | ALOX5 (0.91) | ALOX5OR51E2CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL10307817 | 0.95 | ALOX5 (0.91) | ALOX5OR51E2CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL645127 | 0.94 | ALOX5 (0.89) | ALOX5OR51E2CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL10307751 | 0.94 | ALOX5 (0.89) | ALOX5OR51E2CYP3A4CYP2C8CYP2C9 | |
| Tetrahydrodemethoxycurcumin SCHEMBL29565582 | 0.94 | ALOX5 (0.89) | ALOX5OR51E2CYP3A4CYP2C8CYP2C9 | |
| Tetrahydrodemethoxycurcumin SCHEMBL4413210 | 0.94 | ALOX5 (0.89) | ALOX5OR51E2CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL28355932 | 0.93 | ALOX5 (0.88) | ALOX5OR51E2CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL10307531 | 0.93 | ALOX5 (0.86) | ALOX5OR51E2CYP3A4CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 176 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118986944-A | Application of tetrahydrocurcumin in inhibiting valve mesenchymal cell calcification | 重庆医科大学 | 2024-11-22 | — | — | CN | claimed |
| US-20210060166-A1 | Method for the preparation of a 1,7-bis (4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione system in polysorbates for the formation of micelles in an aqueous medium aimed at the properties of the bioavailability of curcuminoids | ASTUDILLO DE LA VEGA HORACIO (MX) | 2021-03-04 | — | — | US | claimed |
| US-8119696-B2 | Treatment of superficial and cutaneous mycoses with a pure form of 1,7-bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanedione | Majeed, Muhammed (US) | 2012-02-21 | — | — | US | claimed |
| US-20090318565-A1 | Novel Compositions for the Enhancement of the Anti-oxidant Potential of Hydrogenated Curcuminoids or Combinations Thereof | MAJEED MUHAMMED | 2009-12-24 | — | — | US | claimed |
| US-20090275665-A1 | Enhanced biological potential of greater than 99% pure form of 1, 7-bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanedione over corresponding 95% pure form-therapeutic and agricultural applications thereof | SAMI LABS LIMITED (IN) | 2009-11-05 | — | — | US | claimed |
| US-6875426-B2 | Self-tanning composition containing a tetrahydrocurcuminoid and a self-tanning agent | L'OREAL (FR) | 2005-04-05 | — | — | US | claimed |
| US-6872401-B2 | Cosmetic/dermatological compositions comprising a tetrahydrocurcuminoid and an amide oil | L'OREAL (FR) | 2005-03-29 | — | — | US | claimed |
| US-20040009200-A1 | Cosmetic/dermatological compositions comprising a tetrahydrocurcuminoid and an amide oil | SOCIETE L'OREAL S.A. (FR) | 2004-01-15 | — | — | US | claimed |
| US-20030228268-A1 | Self-tanning composition containing a tetrahydrocurcuminoid and a self-tanning agent | SOCIETE L'OREAL S.A. (FR) | 2003-12-11 | — | — | US | claimed |
| EP-1348418-A1 | Cosmetical or dermatological composition containing a tetrahydrocurcumin derivative and an oil bearing an amide group | L'OREAL (FR) | 2003-10-01 | — | — | EP | claimed |
| EP-1348424-A1 | Self-tanning composition containing a tetrahydrocurcumine derivative and a self-tanning agent | L'OREAL (FR) | 2003-10-01 | — | — | EP | claimed |
| US-20250255853-A1 | HUMAN THERAPEUTIC AGENTS | ANKH LIFE SCIENCES LIMITED (IE) | 2025-08-14 | — | — | US | disclosed |
| US-12303470-B2 | Method and composition for selective treatment of androgen receptors | SKINQRI, LLC (US) | 2025-05-20 | — | — | US | disclosed |
| US-12186294-B2 | Modulators of prostate-specific g-protein receptor (PSGR/OR51E2) and methods of using same | DUKE UNIVERSITY (US) | 2025-01-07 | — | — | US | disclosed |
| CN-118986944-A | Application of tetrahydrocurcumin in inhibiting valve mesenchymal cell calcification | 重庆医科大学 | 2024-11-22 | — | — | CN | disclosed |
| US-5208251-A | Compounds for antiinflammatory agents, antiallergens, antiarthritic, antiulcer agents | WARNER-LAMBERT COMPANY (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0245825-B1 | STYRYL PYRAZOLES, ISOXAZOLES AND ANALOGS THEREOF HAVING ACTIVITY AS 5-LIPOXY-GENASE INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | WARNER-LAMBERT COMPANY (US) | 1991-03-13 | — | — | EP | disclosed |
| US-4924002-A | REACTION WITH MOLYBDENUM CARBONYL AND HYDRAZINE | WARNER-LAMBERT COMPANY (US) | 1990-05-08 | — | — | US | disclosed |
| US-4877881-A | SUNSCREEN | WARNER-LAMBERT COMPANY (US) | 1989-10-31 | — | — | US | disclosed |
| EP-0245825-A1 | Styryl pyrazoles, isoxazoles and analogs thereof having activity as 5-lipoxy-genase inhibitors and pharmaceutical compositions containing them | WARNER-LAMBERT COMPANY (US) | 1987-11-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275665-A1 | Enhanced biological potential of greater than 99% pure form of 1, 7-bis(4-hydroxy-3-methoxyphenyl)-3,5-heptanedione over corresponding 95% pure form-therapeutic and agricultural applications thereof | CYP8B1, HPD, HAAO | ALOX5 268/4885OR51E2 906/4885CYP3A4 94/4885 |
| US-12303470-B2 | Method and composition for selective treatment of androgen receptors | AR, ARNT, SHBG | ALOX5 726/4885OR51E2 801/4885CYP3A4 1388/4885 |
| US-20030228268-A1 | Self-tanning composition containing a tetrahydrocurcuminoid and a self-tanning agent | TYR, TES, TERT | ALOX5 963/4885OR51E2 3141/4885CYP3A4 1628/4885 |
| US-20090318565-A1 | Novel Compositions for the Enhancement of the Anti-oxidant Potential of Hydrogenated Curcuminoids or Combinations Thereof | GPX4, HMOX1, GPX1 | ALOX5 36/4885OR51E2 1306/4885CYP3A4 460/4885 |
| US-20040009200-A1 | Cosmetic/dermatological compositions comprising a tetrahydrocurcuminoid and an amide oil | KRT18, DHCR24, FABP4 | ALOX5 39/4885OR51E2 3668/4885CYP3A4 1221/4885 |
| US-20250255853-A1 | HUMAN THERAPEUTIC AGENTS | HASPIN, TIPARP, SHARPIN | ALOX5 2214/4885OR51E2 4014/4885CYP3A4 3496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.