Sugi Predict

Sugi Predict / Compounds / SCHEMBL2850109

SCHEMBL2850109

SCHEMBL2850109

CO[C@H]1CN(C(=O)O)CC[C@H]1NC(=O)OCc1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ CPB1 P15086 2/20 0.52
▸ CTSK P43235 2/20 0.49
▸ CTSL P07711 1/20 0.49
▸ CTSB P07858 1/20 0.49
▸ HSD11B1 P28845 1/20 0.48
▸ NPC1 O15118 2/20 0.47
▸ RAB9A P51151 2/20 0.47
▸ SMN1; SMN2 Q16637 2/20 0.47
▸ ALDH1A1 P00352 1/20 0.47
▸ GAA P10253 1/20 0.47
▸ DPP4 P27487 5/20 0.47
▸ DPP7 Q9UHL4 5/20 0.47
▸ KCNH2 Q12809 3/20 0.47
▸ TSHR P16473 1/20 0.46
▸ HTT P42858 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3109574 1.00 CPB1 (0.52) CPB1CTSKCTSLCTSBHSD11B1
SCHEMBL2850110 1.00 CPB1 (0.52) CPB1CTSKCTSLCTSBHSD11B1
SCHEMBL26621669 1.00 CPB1 (0.52) CPB1CTSKCTSLCTSBHSD11B1
SCHEMBL2823694 0.89 CPB1 (0.51) CPB1CTSKCTSLCTSBHSD11B1
SCHEMBL2824783 0.89 CPB1 (0.48) CPB1CTSKCTSLCTSBHSD11B1
SCHEMBL16390937 0.89 CTSK (0.47) CPB1CTSKCTSLCTSBHSD11B1
SCHEMBL20557170 0.89 CTSK (0.47) CPB1CTSKCTSLCTSBHSD11B1
SCHEMBL2852717 0.89 CTSK (0.47) CPB1CTSKCTSLCTSBHSD11B1
SCHEMBL2852720 0.89 CTSK (0.47) CPB1CTSKCTSLCTSBHSD11B1
SCHEMBL2852833 0.87 HSD11B1 (0.48) CPB1CTSKCTSLCTSBHSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230159491-A1 Antimicrobial Compounds and Methods NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2023-05-25 — — US disclosed
EP-3911644-A1 ANTIMICROBIAL COMPOUNDS AND METHODS Curza Global LLC (US) 2021-11-24 — — EP disclosed
US-10752647-B2 N-phosphonoxymethyl prodrugs of hydroxyalkyl thiadiazole derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2020-08-25 — — US disclosed
WO-2020150385-A1 ANTIMICROBIAL COMPOUNDS AND METHODS CURZA GLOBAL, LLC (US) 2020-07-23 — — WO disclosed
EP-3356361-B1 HYDROXYALKYL THIADIAZOLE DERIVATIVES DAIICHI SANKYO CO LTD (JP) 2020-07-08 — — EP disclosed
US-20200040019-A1 N-PHOSPHONOXYMETHL PRODRUGS OF HYDROXYALKYL THIADIAZOLE DERIVATIVES DAIICHI SANKYO COMPANY, LIMITED (JP) 2020-02-06 — — US disclosed
US-10399968-B2 Hydroxyalkyl thiadiazole derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2019-09-03 — — US disclosed
US-20180327399-A1 HYDROXYALKYL THIADIAZOLE DERIVATIVES DAIICHI SANKYO COMPANY, LIMITED (JP) 2018-11-15 — — US disclosed
WO-2018169092-A1 N-PHOSPHONOXYMETHYL PRODRUGS OF HYDROXYALKYL THIADIAZOLE DERIVATIVES DAIICHI SANKYO COMPANY, LIMITED (JP) 2018-09-20 — — WO disclosed
EP-3356361-A1 HYDROXYALKYL THIADIAZOLE DERIVATIVES DAIICHI SANKYO COMPANY, LIMITED (JP) 2018-08-08 — — EP disclosed
EP-2226322-B1 IMIDAZOLE CARBONYL COMPOUND DAIICHI SANKYO CO LTD (JP) 2015-01-21 — — EP disclosed
US-8927588-B2 Imidazole carbonyl compound DAIICHI SANKYO COMPANY, LIMITED (JP) 2015-01-06 — — US disclosed
US-20140073622-A1 IMIDAZOLE CARBONYL COMPOUND DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-03-13 — — US disclosed
US-8536197-B2 Imidazole carbonyl compound DAIICHI SANKYO COMPANY, LIMITED (JP) 2013-09-17 — — US disclosed
EP-1853586-B1 ANTIBACTERIAL PIPERIDINE DERIVATIVES ASTRAZENECA AB (SE) 2013-07-24 — — EP disclosed
US-20130150366-A1 CHEMICAL COMPOUNDS ASTRAZENECA, INTELLECTUAL PROPERTY (GB) 2013-06-13 — — US disclosed
US-8399489-B2 Antibacterial piperdine derivatives ASTRAZENECA AB (GB) 2013-03-19 — — US disclosed
US-20100311966-A1 IMIDAZOLE CARBONYL COMPOUND DAIICHI SANKYO COMPANY, LIMITED (JP) 2010-12-09 — — US disclosed
EP-2226322-A1 IMIDAZOLE CARBONYL COMPOUND Daiichi Sankyo Company, Limited (JP) 2010-09-08 — — EP disclosed
US-20100179150-A1 ANTIBACTERIAL PIPERDINE DERIVATIVES ASTRAZENECA AB (SE) 2010-07-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230159491-A1 Antimicrobial Compounds and Methods MPO, NISCH, RPN2 CPB1 3064/4885CTSK 151/4885CTSL 111/4885
US-10399968-B2 Hydroxyalkyl thiadiazole derivatives TOP1, TOP2B, TOP2A CPB1 496/4885CTSK 1971/4885CTSL 1643/4885
US-20130150366-A1 CHEMICAL COMPOUNDS MRPL21, NISCH, CFTR CPB1 2237/4885CTSK 913/4885CTSL 1058/4885
US-10752647-B2 N-phosphonoxymethyl prodrugs of hydroxyalkyl thiadiazole derivatives PHYKPL, SLC34A1, PNKP CPB1 1693/4885CTSK 2407/4885CTSL 1643/4885
US-20200040019-A1 N-PHOSPHONOXYMETHL PRODRUGS OF HYDROXYALKYL THIADIAZOLE DERIVATIVES PHYKPL, SLC34A1, PNKP CPB1 1428/4885CTSK 2371/4885CTSL 754/4885
US-20100311966-A1 IMIDAZOLE CARBONYL COMPOUND TOP1, TOP2B, TOP2A CPB1 1454/4885CTSK 1636/4885CTSL 1737/4885
US-20180327399-A1 HYDROXYALKYL THIADIAZOLE DERIVATIVES TOP1, TOP2B, TOP2A CPB1 496/4885CTSK 1971/4885CTSL 1643/4885
US-20100179150-A1 ANTIBACTERIAL PIPERDINE DERIVATIVES PIR, HAMP, AMPD2 CPB1 4206/4885CTSK 1361/4885CTSL 469/4885
US-20140073622-A1 IMIDAZOLE CARBONYL COMPOUND TOP1, TOP2B, TOP2A CPB1 474/4885CTSK 2142/4885CTSL 1294/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.