Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 1/20 | 0.61 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.61 |
| ▸ | ACE | P12821 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.53 |
| ▸ | CTSS | P25774 | 6/20 | 0.52 |
| ▸ | CTSK | P43235 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | KDM4A | O75164 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | BCL2 | P10415 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 4/20 | 0.49 |
| ▸ | PPARG | P37231 | 3/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.48 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2847835 | 1.00 | ITGB3 (0.61) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL1932580 | 1.00 | ITGB3 (0.61) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL2856826 | 0.92 | ITGB3 (0.52) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL18235378 | 0.92 | ITGB3 (0.52) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL2856829 | 0.92 | ITGB3 (0.52) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL7442384 | 0.91 | KLK5 (0.53) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL864694 | 0.91 | KLK5 (0.53) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL1819934 | 0.91 | KLK5 (0.53) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL28706872 | 0.91 | REN (0.52) | ITGB3ITGA2BACEPTPN1CTSS | |
| SCHEMBL31448103 | 0.91 | ITGB3 (0.61) | ITGB3ITGA2BACEPTPN1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230287021-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR STABILIZING TRANSTHYRETIN AND INHIBITING TRANSTHYRETIN MISFOLDING | PROTEGO BIOPHARMA, INC. | 2023-09-14 | — | — | US | disclosed |
| EP-4097092-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR STABILIZING TRANSTHYRETIN AND INHIBITING TRANSTHYRETIN MISFOLDING | Protego Biopharma, Inc. (US) | 2022-12-07 | — | — | EP | disclosed |
| US-11407763-B2 | Tryptophan hydroxylase inhibitor and pharmaceutical composition including same | GWANGJU INSTITUTE OF SCIENCE AND TECHNOLGY (KR) | 2022-08-09 | — | — | US | disclosed |
| EP-3674303-B1 | NOVEL TRYPTOPHAN HYDROXYLASE INHIBITOR AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | GWANGJU INST SCIENCE & TECH (KR) | 2022-07-20 | — | — | EP | disclosed |
| WO-2021154842-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR STABILIZING TRANSTHYRETIN AND INHIBITING TRANSTHYRETIN MISFOLDING | PROTEGO BIOPHARMA, INC. (US) | 2021-08-05 | — | — | WO | disclosed |
| US-11066395-B2 | Dimethylaminoethanol salt of a GLP-1 receptor modulator | RECEPTOS LLC (US) | 2021-07-20 | — | — | US | disclosed |
| US-20210155634-A1 | NOVEL TRYPTOPHAN HYDROXYLASE INHIBITOR AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2021-05-27 | — | — | US | disclosed |
| EP-3172199-B1 | PYRIMIDINE DERIVATIVES AS GLP-1 RECEPTOR MODULATORS | CELGENE INT II SARL (CH) | 2020-07-01 | — | — | EP | disclosed |
| EP-3674303-A1 | NOVEL TRYPTOPHAN HYDROXYLASE INHIBITOR AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | Gwangju Institute of Science and Technology (KR) | 2020-07-01 | — | — | EP | disclosed |
| US-20200131164-A1 | DIMETHYLAMINOETHANOL SALT OF A GLP-1 RECEPTOR MODULATOR | RECEPTOS LLC | 2020-04-30 | — | — | US | disclosed |
| US-20020010199-A1 | Substituted cyclic amidine derivatives as inhibitors of cell adhesion | MERCK SHARP & DOHME CORP. | 2002-01-24 | — | — | US | disclosed |
| US-20010020017-A1 | Squaric acid derivatives | CELLTECH R&D LIMITED (GB) | 2001-09-06 | — | — | US | disclosed |
| WO-2001012183-A1 | HETEROCYCLE AMIDES AS CELL ADHESION INHIBITORS | MERCK & CO., INC. (US) | 2001-02-22 | — | — | WO | disclosed |
| US-6136842-A | INHIBITION OF ENDOTHELIN-CONVERTING ENZYME | HOECHST MARION ROUSSEL (FR) | 2000-10-24 | — | — | US | disclosed |
| EP-0888341-A1 | NOVEL SULPHUR DERIVATIVES COMPRISING AN AMIDE BOND, METHOD FOR PREPARING SAME, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH DERIVATIVES | HOECHST MARION ROUSSEL (FR) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032874-A1 | NOVEL SULPHUR DERIVATIVES COMPRISING AN AMIDE BOND, METHOD FOR PREPARING SAME, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH DERIVATIVES | HOECHST MARION ROUSSEL (FR) | 1997-09-12 | — | — | WO | disclosed |
| EP-0592367-A2 | Phosphono/biaryl substituted dipeptide derivatives | CIBA-GEIGY AG (CH) | 1994-04-13 | — | — | EP | disclosed |
| US-5294632-A | Diuretics and vasorelaxants | CIBA-GEIGY CORPORATION (US) | 1994-03-15 | — | — | US | disclosed |
| EP-0511940-A2 | Phosphono/biaryl substituted dipeptide derivatives | CIBA-GEIGY AG (CH) | 1992-11-04 | — | — | EP | disclosed |
| US-5155100-A | Treating cardiovascular disorders in mammals | CIBA-GEIGY CORPORATION (US) | 1992-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230287021-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR STABILIZING TRANSTHYRETIN AND INHIBITING TRANSTHYRETIN MISFOLDING | TTR, TTPA, TNNC1 | ITGB3 4718/4885ITGA2B 4784/4885ACE 87/4885 |
| US-20200131164-A1 | DIMETHYLAMINOETHANOL SALT OF A GLP-1 RECEPTOR MODULATOR | GLP1R, GIPR, GPR119 | ITGB3 4004/4885ITGA2B 4589/4885ACE 1448/4885 |
| US-11407763-B2 | Tryptophan hydroxylase inhibitor and pharmaceutical composition including same | TPH1, TPH2, IDO1 | ITGB3 4881/4885ITGA2B 4876/4885ACE 2059/4885 |
| US-20210155634-A1 | NOVEL TRYPTOPHAN HYDROXYLASE INHIBITOR AND PHARMACEUTICAL COMPOSITION INCLUDING SAME | TPH1, TPH2, IDO1 | ITGB3 4882/4885ITGA2B 4872/4885ACE 1963/4885 |
| US-20010020017-A1 | Squaric acid derivatives | SUCNR1, HCAR1, CCR1 | ITGB3 81/4885ITGA2B 170/4885ACE 2696/4885 |
| US-11066395-B2 | Dimethylaminoethanol salt of a GLP-1 receptor modulator | GLP1R, GIPR, GPR119 | ITGB3 4004/4885ITGA2B 4589/4885ACE 1448/4885 |
| US-20020010199-A1 | Substituted cyclic amidine derivatives as inhibitors of cell adhesion | VCAM1, CD4, ICAM1 | ITGB3 21/4885ITGA2B 65/4885ACE 1460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.