Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 3/20 | 0.44 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2860210 | 0.92 | NR3C1 (0.42) | NR3C1KEAP1NFE2L2RAB9ASMN1; SMN2 | |
| SCHEMBL2857883 | 0.85 | MAPT (0.44) | RAB9ANPC1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL2850725 | 0.82 | MAPT (0.54) | KEAP1NFE2L2NPC1SMN1; SMN2KDM4E | |
| SCHEMBL2854287 | 0.82 | MAPT (0.52) | NR3C1KEAP1NFE2L2RAB9ASMN1; SMN2 | |
| SCHEMBL2862974 | 0.80 | KEAP1 (0.50) | KEAP1NFE2L2RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2860939 | 0.80 | LMNA (0.45) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL2857954 | 0.79 | RAB9A (0.53) | NR3C1RAB9ANPC1SMN1; SMN2KDM4E | |
| SCHEMBL2848492 | 0.79 | ALDH1A1 (0.47) | KEAP1NFE2L2SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2858122 | 0.78 | MAPT (0.53) | SMN1; SMN2KDM4EALDH1A1POLBMAPT | |
| SCHEMBL2860829 | 0.77 | TNKS (0.42) | SMN1; SMN2KDM4EALDH1A1BRAFMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |