Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 known ✓ | O43570 | 5/20 | 0.43 |
| ▸ | CA1 known ✓ | P00915 | 5/20 | 0.43 |
| ▸ | CA2 known ✓ | P00918 | 5/20 | 0.43 |
| ▸ | CA4 known ✓ | P22748 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | HTR6 | P50406 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 5/20 | 0.43 |
| ▸ | CA6 | P23280 | 4/20 | 0.43 |
| ▸ | CA5A | P35218 | 4/20 | 0.43 |
| ▸ | CA7 | P43166 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30330767 | 1.00 | ALDH1A1 (0.57) | ALDH1A1MAPTPKMMEN1KMT2A | |
| SCHEMBL31120743 | 0.82 | TDP1 (0.69) | ALDH1A1MAPTPKMMEN1KMT2A | |
| SCHEMBL30461613 | 0.82 | LMNA (0.47) | ALDH1A1MAPTPKMMEN1KMT2A | |
| SCHEMBL713915 | 0.82 | LMNA (0.47) | ALDH1A1MAPTPKMMEN1KMT2A | |
| SCHEMBL8772805 | 0.82 | LMNA (0.47) | ALDH1A1MAPTPKMMEN1KMT2A | |
| SCHEMBL1365469 | 0.82 | TDP1 (0.69) | ALDH1A1MAPTPKMMEN1KMT2A | |
| SCHEMBL6520586 | 0.80 | LMNA (0.45) | ALDH1A1MAPTPKMMEN1KMT2A | |
| SCHEMBL28073756 | 0.80 | GAA (0.70) | ALDH1A1MAPTPKMMEN1KMT2A | |
| SCHEMBL27781331 | 0.80 | MAPT (0.50) | ALDH1A1MAPTPKMMEN1KMT2A | |
| Water SCHEMBL27001682 | 0.80 | TDP1 (0.67) | ALDH1A1MAPTPKMMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113600040-B | High-flux polyethylene-based reverse osmosis membrane and preparation method and application thereof | 万华化学集团股份有限公司 | 2023-05-30 | — | — | CN | claimed |
| CN-113600040-A | High-flux polyethylene-based reverse osmosis membrane and preparation method and application thereof | 万华化学集团股份有限公司 | 2021-11-05 | — | — | CN | claimed |
| CN-113600040-B | High-flux polyethylene-based reverse osmosis membrane and preparation method and application thereof | 万华化学集团股份有限公司 | 2023-05-30 | — | — | CN | disclosed |
| CN-115872937-A | Side imidazolyl-containing wholly aromatic side chain type sulfonated diamine monomer, and preparation method and application thereof | 中国石化扬子石油化工有限公司 | 2023-03-31 | — | — | CN | disclosed |
| CN-113600040-A | High-flux polyethylene-based reverse osmosis membrane and preparation method and application thereof | 万华化学集团股份有限公司 | 2021-11-05 | — | — | CN | disclosed |