Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | HTR2B | P41595 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | ACAT2 | Q9BWD1 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14660485 | 0.98 | ADRB1 (0.39) | ADRB1OPRM1GRIN1GRIN2ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL31069247 | 0.87 | HTR2A (0.41) | ADRB1OPRM1GRIN1GRIN2AHDAC4 | |
| Hydrochloric Acid SCHEMBL21810777 | 0.87 | HTR2A (0.41) | ADRB1OPRM1GRIN1GRIN2AHDAC4 | |
| SCHEMBL27671020 | 0.78 | SIGMAR1 (0.42) | OPRM1SIGMAR1HTR2CSLC6A4HTR2A | |
| SCHEMBL3474520 | 0.78 | OPRM1 (0.41) | OPRM1SIGMAR1HDAC4HTR2CHTR2B | |
| SCHEMBL10007606 | 0.78 | HTR2C (0.43) | HTR2CHTR2BSLC6A4HTR2ADRD2 | |
| Hydrochloric Acid SCHEMBL1513481 | 0.77 | OPRM1 (0.39) | OPRM1SIGMAR1HDAC4HTR2CSLC6A4 | |
| SCHEMBL23647453 | 0.77 | ADRB1 (0.40) | ADRB1OPRM1GRIN1GRIN2ASIGMAR1 | |
| SCHEMBL30017530 | 0.77 | ADRB1 (0.40) | ADRB1OPRM1GRIN1GRIN2ASIGMAR1 | |
| SCHEMBL655089 | 0.77 | GRIN1 (0.42) | ADRB1OPRM1GRIN1GRIN2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2477983-B1 | (4-PHENYL-PIPERIDIN-1-YL)-[5-1H-PYRAZOL-4YL)-THIOPHEN-3-YL]-METHANONE COMPOUNDS AND THEIR USE | UNIV EDINBURGH (GB) | 2015-04-15 | — | — | EP | disclosed |
| EP-2477983-B1 | (4-PHENYL-PIPERIDIN-1-YL)-[5-1H-PYRAZOL-4YL)-THIOPHEN-3-YL]-METHANONE COMPOUNDS AND THEIR USE | UNIV EDINBURGH (GB) | 2015-04-15 | — | — | EP | disclosed |
| US-8642621-B2 | (4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds and their use | THE UNIVERSITY OF EDINBURGH (GB) | 2014-02-04 | — | — | US | disclosed |
| US-8642621-B2 | (4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds and their use | THE UNIVERSITY OF EDINBURGH (GB) | 2014-02-04 | — | — | US | disclosed |
| US-8642621-B2 | (4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds and their use | THE UNIVERSITY OF EDINBURGH (GB) | 2014-02-04 | — | — | US | disclosed |
| US-20120172393-A1 | (4-Phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone Compounds and Their Use | THE UNIVERSITY OF EDINBURGH (GB) | 2012-07-05 | — | — | US | disclosed |
| US-20120172393-A1 | (4-Phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone Compounds and Their Use | THE UNIVERSITY OF EDINBURGH (GB) | 2012-07-05 | — | — | US | disclosed |
| US-20120172393-A1 | (4-Phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone Compounds and Their Use | THE UNIVERSITY OF EDINBURGH (GB) | 2012-07-05 | — | — | US | disclosed |
| WO-2011033255-A1 | (4-PHENYL-PIPERIDIN-1-YL)-[5-1H-PYRAZOL-4YL)-THIOPHEN-3-YL]-METHANONE COMPOUNDS AND THEIR USE | THE UNIVERSITY OF EDINBURGH (GB) | 2011-03-24 | — | — | WO | disclosed |
| US-7855294-B2 | Cycloalkanopyridine derivative | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-12-21 | — | — | US | disclosed |
| US-20070191419-A1 | Cycloalkanopyridine derivative | MSD K.K. (JP) | 2007-08-16 | — | — | US | disclosed |
| EP-1726590-A1 | CYCLOALKANOPYRIDINE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2006-11-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172393-A1 | (4-Phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone Compounds and Their Use | HSD11B1, HSD17B1, HSD3B1 | ADRB1 200/4885OPRM1 2715/4885GRIN1 141/4885 |
| US-20070191419-A1 | Cycloalkanopyridine derivative | OPRL1, OPRK1, AVPR2 | ADRB1 110/4885OPRM1 13/4885GRIN1 131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.