Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 3/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1513481 | 0.98 | OPRM1 (0.39) | OPRM1SIGMAR1HDAC4HTR2CHTR2A | |
| SCHEMBL14660963 | 0.89 | HTR2A (0.43) | OPRM1SIGMAR1HDAC4HTR2CHTR2A | |
| Hydrochloric Acid SCHEMBL14660553 | 0.83 | HDAC4 (0.41) | OPRM1SIGMAR1HDAC4HTR2CHTR2A | |
| SCHEMBL27671020 | 0.80 | SIGMAR1 (0.42) | OPRM1SIGMAR1HTR2CHTR2ASLC6A2 | |
| SCHEMBL31158700 | 0.79 | HDAC4 (0.37) | OPRM1HDAC4HTR2CHTR2ASLC6A2 | |
| SCHEMBL10820262 | 0.78 | SIGMAR1 (0.41) | OPRM1SIGMAR1HDAC4HTR2CHTR2A | |
| SCHEMBL615903 | 0.78 | SIGMAR1 (0.57) | OPRM1SIGMAR1HDAC4HTR2CHTR2A | |
| SCHEMBL2882928 | 0.78 | ADRB1 (0.40) | OPRM1SIGMAR1HDAC4HTR2CHTR2A | |
| Hydrochloric Acid SCHEMBL14660717 | 0.78 | HTR2C (0.42) | OPRM1SIGMAR1HTR2CSLC6A2DRD2 | |
| Hydrochloric Acid SCHEMBL4894805 | 0.77 | OPRM1 (0.54) | OPRM1SIGMAR1HDAC4HTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2477983-B1 | (4-PHENYL-PIPERIDIN-1-YL)-[5-1H-PYRAZOL-4YL)-THIOPHEN-3-YL]-METHANONE COMPOUNDS AND THEIR USE | UNIV EDINBURGH (GB) | 2015-04-15 | — | — | EP | disclosed |
| US-8642621-B2 | (4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds and their use | THE UNIVERSITY OF EDINBURGH (GB) | 2014-02-04 | — | — | US | disclosed |
| US-8642621-B2 | (4-phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone compounds and their use | THE UNIVERSITY OF EDINBURGH (GB) | 2014-02-04 | — | — | US | disclosed |
| US-20120172393-A1 | (4-Phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone Compounds and Their Use | THE UNIVERSITY OF EDINBURGH (GB) | 2012-07-05 | — | — | US | disclosed |
| US-20120172393-A1 | (4-Phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone Compounds and Their Use | THE UNIVERSITY OF EDINBURGH (GB) | 2012-07-05 | — | — | US | disclosed |
| WO-2011033255-A1 | (4-PHENYL-PIPERIDIN-1-YL)-[5-1H-PYRAZOL-4YL)-THIOPHEN-3-YL]-METHANONE COMPOUNDS AND THEIR USE | THE UNIVERSITY OF EDINBURGH (GB) | 2011-03-24 | — | — | WO | disclosed |
| EP-2265600-A1 | PYRIDINYL AMIDES FOR THE TREATMENT OF CNS AND METABOLIC DISORDERS | Pfizer Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009098576-A1 | PYRIDINYL AMIDES FOR THE TREATMENT OF CNS AND METABOLIC DISORDERS | PFIZER INC. (US) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009098576-A1 | PYRIDINYL AMIDES FOR THE TREATMENT OF CNS AND METABOLIC DISORDERS | PFIZER INC. (US) | 2009-08-13 | — | — | WO | disclosed |
| US-20090197859-A1 | Pyridinyl Amides for the Treatment of CNS and Metabolic Disorders | PFIZER INC. | 2009-08-06 | — | — | US | disclosed |
| US-20090197859-A1 | Pyridinyl Amides for the Treatment of CNS and Metabolic Disorders | PFIZER INC. | 2009-08-06 | — | — | US | disclosed |
| US-20090197859-A1 | Pyridinyl Amides for the Treatment of CNS and Metabolic Disorders | PFIZER INC. | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197859-A1 | Pyridinyl Amides for the Treatment of CNS and Metabolic Disorders | HTR6, HTR5A, TPH1 | OPRM1 77/4885SIGMAR1 214/4885HDAC4 2384/4885 |
| US-20120172393-A1 | (4-Phenyl-piperidin-1-yl)-[5-(1H-pyrazol-4-yl)-thiophen-3-yl]-methanone Compounds and Their Use | HSD11B1, HSD17B1, HSD3B1 | OPRM1 2715/4885SIGMAR1 1733/4885HDAC4 486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.