Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3015784 | 0.89 | MAOA (0.40) | ALDH1A1MAPK1MAOAMAOBAR | |
| SCHEMBL7276198 | 0.87 | SOAT1 (0.36) | ALDH1A1MAPK1MAOAMAOBAR | |
| SCHEMBL11221141 | 0.85 | THRA (0.38) | MAOAMAOBSOAT1PTGS2 | |
| SCHEMBL11232325 | 0.85 | THRA (0.38) | MAOAMAOBSOAT1PTGS2 | |
| SCHEMBL972188 | 0.83 | — | — | |
| SCHEMBL5463978 | 0.80 | ALDH1A1 (0.38) | ALDH1A1MAPK1 | |
| SCHEMBL10534853 | 0.79 | HTR7 (0.42) | DRD2 | |
| SCHEMBL8508068 | 0.76 | ALDH1A1 (0.34) | ALDH1A1MAPK1 | |
| SCHEMBL3612916 | 0.75 | — | — | |
| SCHEMBL3017420 | 0.74 | MAOA (0.41) | MAOAMAOBRAB9AMTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195289-B1 | PYRROLE COMPOUNDS AS INHIBITORS OF MYCOBACTERIA, SYNTHESIS THEREOF ANS INTERMEDIATES THERETO | UNIV ROMA (IT) | 2013-06-19 | — | — | EP | claimed |
| US-8304410-B2 | Pyrrole compounds as inhibitors of mycobacteria, synthesis thereof and intermediates thereto | Università degli Studi di Roma “La Sapienza” (IT) | 2012-11-06 | — | — | US | claimed |
| US-20100197672-A1 | PYRROLE COMPOUNDS AS INHIBITORS OF MYCOBACTERIA, SYNTHESIS THEREOF AND INTERMEDIATES THERETO | UNIVERSITA DEGLI STUDI DI ROMA "LA SAPIENZA" (IT) | 2010-08-05 | — | — | US | claimed |
| EP-2195289-A2 | PYRROLE COMPOUNDS AS INHIBITORS OF MYCOBACTERIA, SYNTHESIS THEREOF ANS INTERMEDIATES THERETO | Universita'Degli Studi di Roma "La Sapienza" (IT) | 2010-06-16 | — | — | EP | claimed |
| EP-2045237-A1 | Pyrrole compounds as inhibitors of mycrobacteria, synthesis thereof and intermediates thereto | Universita'Degli Studi di Roma "La Sapienza" (IT) | 2009-04-08 | — | — | EP | claimed |
| WO-2009040755-A2 | PYRROLE COMPOUNDS AS INHIBITORS OF MYCOBACTERIA, SYNTHESIS THEREOF ANS INTERMEDIATES THERETO | Università degli Studi di Roma 'La Sapienza' (IT) | 2009-04-02 | — | — | WO | claimed |
| US-7402589-B2 | Tri-substituted ureas as cytokine inhibitors | THE PROCTER & GAMBLE COMPANY (US) | 2008-07-22 | — | — | US | claimed |
| EP-1737830-A1 | TRI-SUBSTITUTED UREAS AS CYTOKINE INHIBITORS | The Procter and Gamble Company (US) | 2007-01-03 | — | — | EP | claimed |
| WO-2005105757-A1 | TRI-SUBSTITUTED UREAS AS CYTOKINE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 2005-11-10 | — | — | WO | claimed |
| US-20050245555-A1 | Tri-substituted ureas as cytokine inhibitors | THE PROCTER & GAMBLE COMPANY (US) | 2005-11-03 | — | — | US | claimed |
| EP-2195289-B1 | PYRROLE COMPOUNDS AS INHIBITORS OF MYCOBACTERIA, SYNTHESIS THEREOF ANS INTERMEDIATES THERETO | UNIV ROMA (IT) | 2013-06-19 | — | — | EP | disclosed |
| US-8304410-B2 | Pyrrole compounds as inhibitors of mycobacteria, synthesis thereof and intermediates thereto | Università degli Studi di Roma “La Sapienza” (IT) | 2012-11-06 | — | — | US | disclosed |
| US-7803827-B2 | 1-N-amino-2-imidazolidinones and derivatives thereof which are effective as Kv1.5 potassium channel inhibitors providing atrial-selective antiarrhythmic agents; 1-(aminosulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(3,4-dimethylphenyl)-2-imidazolidinone | WYETH LLC (US) | 2010-09-28 | — | — | US | disclosed |
| US-20100197672-A1 | PYRROLE COMPOUNDS AS INHIBITORS OF MYCOBACTERIA, SYNTHESIS THEREOF AND INTERMEDIATES THERETO | UNIVERSITA DEGLI STUDI DI ROMA "LA SAPIENZA" (IT) | 2010-08-05 | — | — | US | disclosed |
| EP-2195289-A2 | PYRROLE COMPOUNDS AS INHIBITORS OF MYCOBACTERIA, SYNTHESIS THEREOF ANS INTERMEDIATES THERETO | Universita'Degli Studi di Roma "La Sapienza" (IT) | 2010-06-16 | — | — | EP | disclosed |
| US-4673737-A | ANTIBIOTICS/ | HARVARD UNIVERSITY (US) | 1987-06-16 | — | — | US | disclosed |
| EP-0211540-A1 | Intermediates and process for antibiotics | THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1987-02-25 | — | — | EP | disclosed |
| US-4147805-A | VASODILATION, ANTISPASMODIC AGENTS, ANTICOAGULATNS, ADRENOLYTIC AGENTS | MEAD JOHNSON & COMPANY (US) | 1979-04-03 | — | — | US | disclosed |
| US-4120886-A | APHIDICIDES | PPG INDUSTRIES, INC. (US) | 1978-10-17 | — | — | US | disclosed |
| US-4055656-A | S-ARYL-N-CYCLOALKYLTHIOLCARBAMATES | PPG INDUSTRIES, INC. (US) | 1977-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245555-A1 | Tri-substituted ureas as cytokine inhibitors | IL1B, IL1A, IL6 | ALDH1A1 455/4885MAPK1 1198/4885CA12 3132/4885 |
| US-20100197672-A1 | PYRROLE COMPOUNDS AS INHIBITORS OF MYCOBACTERIA, SYNTHESIS THEREOF AND INTERMEDIATES THERETO | PPOX, FDPS, GGPS1 | ALDH1A1 3225/4885MAPK1 409/4885CA12 4674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.