SCHEMBL289673

SCHEMBL289673

Nc1ccc(C(O)(C(F)(F)F)C(F)(F)F)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
NR1H2 P55055 13/20 0.56
NR1H3 Q13133 13/20 0.56
GCK P35557 1/20 0.50
KIF11 P52732 1/20 0.50
MLYCD O95822 2/20 0.48
SMN1; SMN2 Q16637 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL20271430 0.98 NR1H2 (0.54) NR1H2NR1H3GCKKIF11MLYCD
SCHEMBL24031020 0.93 KIF11 (0.61) NR1H2NR1H3GCKKIF11MLYCD
SCHEMBL131990 0.87 NR1H2 (0.68) NR1H2NR1H3MLYCDSMN1; SMN2
Water SCHEMBL1684070 0.84 NR1H2 (0.65) NR1H2NR1H3MLYCDSMN1; SMN2
SCHEMBL9621271 0.79 NR1H2 (0.60) NR1H2NR1H3KIF11MLYCDSMN1; SMN2
SCHEMBL24901413 0.79 NR1H2 (0.61) NR1H2NR1H3MLYCDSMN1; SMN2
SCHEMBL1516045 0.77 ESR1 (0.61) NR1H2NR1H3KIF11MLYCDSMN1; SMN2
SCHEMBL6808538 0.77 ESR1 (0.61) NR1H2NR1H3MLYCDSMN1; SMN2
SCHEMBL8021367 0.77 NR1H2 (0.58) NR1H2NR1H3MLYCDSMN1; SMN2
SCHEMBL24031277 0.76 RORC (0.56)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 560 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119823651-A Insect pest prevention water-based asphalt paint for container underframe and processing technology thereof 安徽欣苗新材料科技有限公司 2025-04-15 CN claimed
CN-118546665-A Preparation method and application of acidizing corrosion inhibitor suitable for multi-medium acid 山东滨州昱诚化工科技有限公司 2024-08-27 CN claimed
CN-115850756-B Preparation method of acidic ionic gel film based on hydrogen bond, gas sensor and preparation method 西安交通大学 2024-07-30 CN claimed
CN-117466838-A Fluorine-containing monomer, fluorine-containing epoxy resin and preparation method thereof 四川轻化工大学 2024-01-30 CN claimed
CN-116694193-A High weather-resistant and high chemical corrosion-resistant epoxy powder coating and preparation method thereof 浙江捷宇新材料科技股份有限公司 2023-09-05 CN claimed
CN-115850756-A Preparation method of hydrogen bond-based acidic ion gel film, gas sensor and preparation method 西安交通大学 2023-03-28 CN claimed
CN-114752337-A Waterproof MS sealant and preparation method thereof 江苏瑞洋安泰新材料科技有限公司 2022-07-15 CN claimed
JP-2007523865-A 2007-08-23 JP claimed
US-7129235-B2 Amides useful for treating pain ABBOTT LABORATORIES (US) 2006-10-31 US claimed
EP-1646621-A2 NOVEL AZAHETEROCYCLIC AMIDES USEFUL FOR TREATING PAIN Abbott Laboratories (US) 2006-04-19 EP claimed
US-20050080095-A1 administering a therapeuitcally effective amount of 3'-(trifluoromethyl)-N-{4-[(trifluoromethyl)sulfonyl]phenyl}-3,6-dihydro-2H-1,2'-bipyridine-4-carboxamide; antagonists of vanilloid receptor subtype I ABBVIE INC. 2005-04-14 US claimed
WO-2005007642-A2 NOVEL AZAHETEROCYCLIC AMIDES USEFUL FOR TREATING PAIN ABBOTT LABORATORIES (US) 2005-01-27 WO claimed
EP-4747621-A1 SPECIFIC AND LABEL-FREE SENSING OF SMALL MOLECULE TARGETS USING BIOLOGICAL TRANSISTORS B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University (IL) 2026-05-27 EP disclosed
US-12540117-B2 Aniline compound used as RORγ regulator SHANGHAI LITEDD CO., LTD. (CN) 2026-02-03 US disclosed
CN-120741572-A Method for detecting methyl dimethyl phosphonate at room temperature by using surface modified transition metal dichalcogenide nano material 青岛大学 2025-10-03 CN disclosed
CN-119119687-B High-speed copper-clad plate prepared from functional plastics 广东盈华电子材料有限公司 2025-06-24 CN disclosed
EP-0008768-A1 Aroyl ureas, process for their preparation and their use in insecticidal and acaricidal compositions BASF Aktiengesellschaft (DE) 1980-03-19 EP disclosed
US-4156016-A ANTICOAGULANTS HOFFMANN-LA ROCHE INC. (US) 1979-05-22 US disclosed
US-4093742-A Anti-hypertensive polyhaloisopropyl-substituted arylureas SCHERING CORPORATION (US) 1978-06-06 US disclosed
US-3931210-A Production of p-aminobenzoic acid AKZO N.V. (NL) 1976-01-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12540117-B2 Aniline compound used as RORγ regulator RORA, RORB, RORC NR1H2 8/4885NR1H3 7/4885GCK 3932/4885
US-20050080095-A1 administering a therapeuitcally effective amount of 3'-(trifluoromethyl)-N-{4-[(trifluoromethyl)sulfonyl]phenyl}-3,6-dihydro-2H-1,2'-bipyridine-4-carboxamide; antagonists of vanilloid receptor subtype I TRPV1, OPRL1, TRPV6 NR1H2 544/4885NR1H3 614/4885GCK 3750/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.