Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.35 |
| ▸ | RELA | Q04206 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13637128 | 0.81 | HSF1 (0.38) | EPHX2MAPTHSD17B10RAB9ASMN1; SMN2 | |
| SCHEMBL8212044 | 0.79 | ALDH1A1 (0.40) | EPHX2MAPTMEN1KMT2AHSD17B10 | |
| SCHEMBL13947011 | 0.78 | LMNA (0.49) | SMN1; SMN2LMNATRPM8 | |
| SCHEMBL13863822 | 0.78 | RAB9A (0.35) | MAPTALOX12MEN1KMT2AHSD17B10 | |
| SCHEMBL10162476 | 0.76 | PPARA (0.34) | EPHX2MAPTMEN1KMT2ARAB9A | |
| SCHEMBL15422384 | 0.74 | MAPT (0.45) | MAPTALOX12MEN1KMT2AHSD17B10 | |
| SCHEMBL23625618 | 0.73 | ABCG2 (0.50) | MAPTALOX12HSD17B10RAB9ASMN1; SMN2 | |
| SCHEMBL6156434 | 0.73 | EPHX2 (0.33) | EPHX2TRPM8PPARA | |
| SCHEMBL10130594 | 0.72 | NPC1 (0.33) | EPHX2RAB9ASMN1; SMN2NPC1NFKB1 | |
| SCHEMBL6156613 | 0.72 | TRPM8 (0.32) | EPHX2TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8785377-B2 | Tetrazolyl macrocyclic hepatitis C serine protease inhibitors | ENANTA PHARMACEUTICALS, INC. (US) | 2014-07-22 | — | — | US | disclosed |
| US-20100286211-A1 | OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS | RANBAXY LABORATORIES LIMITED (IN) | 2010-11-11 | — | — | US | disclosed |
| US-20090035271-A1 | TETRAZOLYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. | 2009-02-05 | — | — | US | disclosed |
| WO-2008019289-A2 | TETRAZOLYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |
| EP-1799677-A1 | OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS | Ranbaxy Laboratories Limited (IN) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006038100-A1 | OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS | RANBAXY LABORATORIES LIMITED (IN) | 2006-04-13 | — | — | WO | disclosed |
| US-20050267054-A1 | Antibacterial compounds with improved pharmacokinetic profiles | CLARK RICHARD F | 2005-12-01 | — | — | US | disclosed |
| EP-1501845-A1 | ANTIBACTERIAL COMPOUNDS WITH IMPROVED PHARMACOKINETIC PROFILES | Abbott Laboratories (US) | 2005-02-02 | — | — | EP | disclosed |
| EP-1501519-A1 | 9-OXIME MACROLIDE ANTIBACTERIALS | Abbott Laboratories (US) | 2005-02-02 | — | — | EP | disclosed |
| US-20040033970-A1 | Antibacterial compounds with improved pharmacokinetic profiles | ABBOTT LABORATORIES | 2004-02-19 | — | — | US | disclosed |
| US-20040014691-A1 | 9-Oxime macrolide antibacterials | ABBOTT LABORATORIES | 2004-01-22 | — | — | US | disclosed |
| WO-2003093288-A1 | ANTIBACTERIAL COMPOUNDS WITH IMPROVED PHARMACOKINETIC PROFILES | ABBOTT LABORATORIES (US) | 2003-11-13 | — | — | WO | disclosed |
| WO-2003090761-A1 | 9-OXIME MACROLIDE ANTIBACTERIALS | ABBOTT LABORATORIES (US) | 2003-11-06 | — | — | WO | disclosed |
| US-20030207820-A1 | Antibacterial compounds with improved pharmacokinetic profiles | ABBOTT LABORATORIES | 2003-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090035271-A1 | TETRAZOLYL MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS | TMPRSS4, PRSS1, SPINT2 | EPHX2 1860/4885MAPT 3832/4885ALOX12 2874/4885 |
| US-20050267054-A1 | Antibacterial compounds with improved pharmacokinetic profiles | ABCB11, SLC10A2, SI | EPHX2 1648/4885MAPT 4130/4885ALOX12 1294/4885 |
| US-20040014691-A1 | 9-Oxime macrolide antibacterials | CYP2C9, CYP1B1, SULT1E1 | EPHX2 1944/4885MAPT 4791/4885ALOX12 365/4885 |
| US-20100286211-A1 | OXAZOLIDINONE DERIVATIVES AS ANTIMICROBIALS | OXA1L, PDK4, MLYCD | EPHX2 4819/4885MAPT 2191/4885ALOX12 2299/4885 |
| US-20030207820-A1 | Antibacterial compounds with improved pharmacokinetic profiles | UGT1A1, ABCB11, SLC10A1 | EPHX2 2210/4885MAPT 4491/4885ALOX12 1307/4885 |
| US-20040033970-A1 | Antibacterial compounds with improved pharmacokinetic profiles | UGT1A1, ABCB11, SLC10A1 | EPHX2 2210/4885MAPT 4491/4885ALOX12 1307/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.