Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 9/20 | 0.56 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 2/20 | 0.53 |
| ▸ | BCHE | P06276 | 8/20 | 0.55 |
| ▸ | BACE1 | P56817 | 8/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.55 |
| ▸ | CCR3 | P51677 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2495449 | 1.00 | ACHE (0.56) | ACHEBCHEBACE1LTA4HCCR3 | |
| SCHEMBL42501 | 0.98 | ACHE (0.58) | ACHEBCHEBACE1LTA4HCCR3 | |
| SCHEMBL14793661 | 0.98 | ACHE (0.58) | ACHEBCHEBACE1LTA4HCCR3 | |
| SCHEMBL330609 | 0.98 | ACHE (0.58) | ACHEBCHEBACE1LTA4HCCR3 | |
| SCHEMBL239922 | 0.98 | ACHE (0.58) | ACHEBCHEBACE1LTA4HCCR3 | |
| Hydrochloric Acid SCHEMBL20183286 | 0.96 | ACHE (0.56) | ACHEBCHEBACE1LTA4HCCR3 | |
| Hydrochloric Acid SCHEMBL2905438 | 0.96 | ACHE (0.56) | ACHEBCHEBACE1LTA4HCCR3 | |
| Hydrochloric Acid SCHEMBL697482 | 0.96 | ACHE (0.56) | ACHEBCHEBACE1LTA4HCCR3 | |
| Acetic Acid SCHEMBL2500600 | 0.89 | ACHE (0.53) | ACHELTA4HALDH1A1SIGMAR1DRD2 | |
| Acetic Acid SCHEMBL2904677 | 0.89 | ACHE (0.53) | ACHELTA4HALDH1A1SIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1491530-B1 | METHOD OF HEIGHTENING OPTICAL PURITY OF 1-BENZYL-3-AMINOPYRROLIDINE AND SALT FOR USE THEREIN | KANEKA CORP (JP) | 2010-08-11 | — | — | EP | disclosed |
| US-20080255371-A1 | hydrobromic acid, methanesulfonic acid or acetic acid salt of l-benzyl-3-aminopyrrolidine, useful as a synthetic intermediate in medicines and agricultural chemicals | KANEKA CORPORATION (JP) | 2008-10-16 | — | — | US | disclosed |
| US-7268236-B2 | Method of heightening optical purity of 1-benzyl-3-aminopyrrolidine and salt for used therein | KANEKA CORPORATION (JP) | 2007-09-11 | — | — | US | disclosed |
| US-20040249169-A1 | Method of heightening optical purity of 1-benzyl-3-aminopyrrolidine and salt for used therein | KANEKA CORPORATION (JP) | 2004-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255371-A1 | hydrobromic acid, methanesulfonic acid or acetic acid salt of l-benzyl-3-aminopyrrolidine, useful as a synthetic intermediate in medicines and agricultural chemicals | ALAD, HPD, AASDHPPT | ACHE 1569/4885SIGMAR1 2248/4885BCHE 730/4885 |
| US-20040249169-A1 | Method of heightening optical purity of 1-benzyl-3-aminopyrrolidine and salt for used therein | NPEPPS, QDPR, REN | ACHE 1047/4885SIGMAR1 1338/4885BCHE 1622/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.