SCHEMBL29324248

SCHEMBL29324248

CC(C)(C)OC(=O)N1CCC(C(F)(F)C(=O)Nc2cccc3c(CC(=O)O)noc23)CC1

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.41
KDM4E B2RXH2 1/20 0.40
PKM P14618 1/20 0.40
HDAC4 P56524 1/20 0.38
CCR8 P51685 1/20 0.38
TGFBR1 P36897 3/20 0.38
GPR119 Q8TDV5 6/20 0.38
GAA P10253 1/20 0.38
THRB P10828 1/20 0.38
STS P08842 1/20 0.37
PTPN2 P17706 1/20 0.37
PTPN1 P18031 1/20 0.37
PTPN6 P29350 1/20 0.37
NPC1 O15118 1/20 0.36
LMNA P02545 1/20 0.36
NR2F2 P24468 1/20 0.36
HTT P42858 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29324249 0.90 TP53 (0.38) SMN1; SMN2KDM4EPKMHDAC4CCR8
SCHEMBL29324051 0.81 CHRM2 (0.46) SMN1; SMN2NPC1LMNANR2F2HTT
SCHEMBL29324252 0.79 DDB1 (0.47) HDAC4GPR119
SCHEMBL29324244 0.78 TGFBR1 (0.41) KDM4EPKMCCR8TGFBR1GPR119
SCHEMBL29324151 0.76 L3MBTL1 (0.41) KDM4EPKMCCR8TGFBR1GPR119
SCHEMBL29324241 0.73 TGFBR1 (0.43) KDM4EPKMTGFBR1GPR119STS
SCHEMBL29324152 0.72 DDB1 (0.49) KDM4EPKMCCR8TGFBR1GPR119
SCHEMBL29324508 0.71 SMN1; SMN2 (0.45) SMN1; SMN2NPC1LMNANR2F2HTT
SCHEMBL25604354 0.70 SMN1; SMN2 (0.42) SMN1; SMN2HDAC4GPR119NPC1
SCHEMBL29324607 0.68 SMN1; SMN2 (0.43) SMN1; SMN2KDM4ENPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4400499-A1 GLUTARIMIDE COMPOUND AND USE THEREOF Medshine Discovery Inc. (CN) 2024-07-17 EP disclosed