Sugi Predict

Sugi Predict / Compounds / SCHEMBL2934451

SCHEMBL2934451

SCHEMBL2934451

COc1cccc(CS(=O)(=O)Cl)c1

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ TAAR1 Q96RJ0 3/20 0.51
▸ IDO1 P14902 2/20 0.51
▸ AGXT P21549 2/20 0.51
▸ CMA1 P23946 1/20 0.51
▸ ALDH1A1 P00352 3/20 0.49
▸ MAPT P10636 2/20 0.49
▸ HTT P42858 1/20 0.49
▸ SMN1; SMN2 Q16637 1/20 0.49
▸ SIGMAR1 Q99720 2/20 0.49
▸ CHRM2 P08172 1/20 0.49
▸ CHRM1 P11229 1/20 0.49
▸ CHRM3 P20309 1/20 0.49
▸ LMNA P02545 1/20 0.48
▸ TP53 P04637 1/20 0.48
▸ CYP1A2 P05177 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2718014 0.85 TAAR1 (0.55) TAAR1IDO1AGXTCMA1ALDH1A1
SCHEMBL6011474 0.84 TAAR1 (0.53) TAAR1IDO1AGXTCMA1ALDH1A1
SCHEMBL28142535 0.84 TAAR1 (0.53) TAAR1IDO1AGXTCMA1ALDH1A1
SCHEMBL15876075 0.84 TAAR1 (0.53) TAAR1IDO1AGXTCMA1ALDH1A1
SCHEMBL2932625 0.82 TAAR1 (0.51) TAAR1IDO1AGXTCMA1ALDH1A1
SCHEMBL3588710 0.82 TAAR1 (0.56) TAAR1IDO1AGXTCMA1ALDH1A1
SCHEMBL18602238 0.82 TAAR1 (0.51) TAAR1IDO1AGXTCMA1ALDH1A1
SCHEMBL9421746 0.82 FAAH (0.52) TAAR1IDO1AGXTCMA1ALDH1A1
SCHEMBL2932622 0.82 TAAR1 (0.51) TAAR1IDO1AGXTCMA1ALDH1A1
SCHEMBL3061892 0.81 ALDH1A1 (0.46) ALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240277683-A1 COMPOUNDS CTXT PTY LTD (AU) 2024-08-22 — — US disclosed
US-20240270762-A1 PENICILLIN-BINDING PROTEIN INHIBITORS SPRING MILL PHARMA, INC. 2024-08-15 — — US disclosed
EP-4347607-A1 PENICILLIN-BINDING PROTEIN INHIBITORS Venatorx Pharmaceuticals, Inc. (US) 2024-04-10 — — EP disclosed
CN-117693511-A Penicillin binding protein inhibitors 维纳拓尔斯制药公司 2024-03-12 — — CN disclosed
US-11911372-B2 Compounds CTXT PTY LTD (AU) 2024-02-27 — — US disclosed
US-11911372-B2 Compounds CTXT PTY LTD (AU) 2024-02-27 — — US disclosed
US-11911372-B2 Compounds CTXT PTY LTD (AU) 2024-02-27 — — US disclosed
CN-115427410-B Amide or sulfonamide derivatives and application thereof 苏州恩华生物医药科技有限公司 2024-02-23 — — CN disclosed
US-11773058-B2 Sulfonamide carboxamide compounds INFLAZOME LIMITED (IE) 2023-10-03 — — US disclosed
US-11518739-B2 Sulfonamide carboxamide compounds INFLAZOME LIMITED (IE) 2022-12-06 — — US disclosed
US-20100261701-A1 8-Substituted isoquinoline derivative and the use thereof ASAHI KASEI PHARMA CORPORATION (JP) 2010-10-14 — — US disclosed
US-20100261701-A1 8-Substituted isoquinoline derivative and the use thereof ASAHI KASEI PHARMA CORPORATION (JP) 2010-10-14 — — US disclosed
EP-1836163-B1 PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN NOVARTIS AG (CH) 2010-09-22 — — EP disclosed
EP-2217578-A1 [1,2,4]TRIAZOLO[1,5-A]PYRIDINE AND [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE COMPOUNDS AND THEIR USE Cancer Research Technology Limited (GB) 2010-08-18 — — EP disclosed
US-20100087427-A1 PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN BREITENSTEIN WERNER 2010-04-08 — — US disclosed
WO-2010038465-A1 8-SUBSTITUTED ISOQUINOLINE DERIVATIVE AND USE THEREOF 旭化成ファーマ株式会社 (JP) 2010-04-08 — — WO disclosed
WO-2009047514-A1 [1,2,4]TRIAZOLO[1,5-A]PYRIDINE AND [1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE COMPOUNDS AND THEIR USE CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2009-04-16 — — WO disclosed
EP-1836163-A2 PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN Novartis AG (CH) 2007-09-26 — — EP disclosed
WO-2006066896-A2 PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN NOVARTIS AG (CH) 2006-06-29 — — WO disclosed
WO-1994018165-A1 SULFONAMIDE COMPOUNDS AS OPIOID K-RECEPTOR AGONISTS PFIZER INC. (US) 1994-08-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100087427-A1 PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF A DISEASE DEPENDING ON THE ACTIVITY OF RENIN REN, ACE, PEPD TAAR1 1451/4885IDO1 1139/4885AGXT 1333/4885
US-20240277683-A1 COMPOUNDS SLC10A1, ABCB11, REN TAAR1 3336/4885IDO1 3435/4885AGXT 625/4885
US-11773058-B2 Sulfonamide carboxamide compounds NLRP3, NOD1, NLRP1 TAAR1 1368/4885IDO1 2874/4885AGXT 1999/4885
US-20100261701-A1 8-Substituted isoquinoline derivative and the use thereof RELA, NFKBIA, NFKB2 TAAR1 2322/4885IDO1 514/4885AGXT 3177/4885
US-20240270762-A1 PENICILLIN-BINDING PROTEIN INHIBITORS PEPD, BPGM, EBPL TAAR1 4831/4885IDO1 3265/4885AGXT 676/4885
US-11911372-B2 Compounds SLC10A1, ABCB11, REN TAAR1 2933/4885IDO1 3182/4885AGXT 708/4885
US-11518739-B2 Sulfonamide carboxamide compounds NLRP3, PYCARD, NOD1 TAAR1 2561/4885IDO1 1904/4885AGXT 1596/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.