Butropium

Butropium

SCHEMBL29388793

CCCCOc1ccc(C[N+]2(C)[C@@H]3CC[C@H]2C[C@H](OC(=O)C(CO)c2ccccc2)C3)cc1

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 6/20 0.63
BLM P54132 3/20 0.62
PABPC1 P11940 1/20 0.62
CYP2C19 P33261 1/20 0.61
CHRM1 P11229 4/20 0.60
CHRM5 P08912 3/20 0.60
TSHR P16473 2/20 0.60
MEN1 O00255 2/20 0.60
KMT2A Q03164 2/20 0.60
CHRM4 P08173 2/20 0.60
CHRM3 P20309 2/20 0.60
PMP22 Q01453 2/20 0.58
CYP2D6 P10635 1/20 0.58
KCNH2 Q12809 1/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
LMNA P02545 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Butropium SCHEMBL11561521 0.99 BLM (0.64) CHRM2BLMPABPC1CYP2C19CHRM1
Butropium SCHEMBL1650524 0.99 BLM (0.64) CHRM2BLMPABPC1CYP2C19CHRM1
Butropium SCHEMBL26023 0.99 BLM (0.64) CHRM2BLMPABPC1CYP2C19CHRM1
Butropium SCHEMBL30185784 0.99 BLM (0.64) CHRM2BLMPABPC1CYP2C19CHRM1
Bromide SCHEMBL29840597 0.87 BLM (0.77) CHRM2BLMPABPC1CYP2C19CHRM1
Xenytropium SCHEMBL29361010 0.86 CHRM2 (0.71) CHRM2BLMPABPC1CYP2C19CHRM1
Xenytropium SCHEMBL30428452 0.86 CHRM2 (0.71) CHRM2BLMPABPC1CYP2C19CHRM1
Xenytropium SCHEMBL24707 0.85 BLM (0.71) CHRM2BLMPABPC1CYP2C19CHRM1
Xenytropium SCHEMBL29371652 0.85 BLM (0.71) CHRM2BLMPABPC1CYP2C19CHRM1
SCHEMBL14652328 0.82 CHRM2 (0.77) CHRM2BLMPABPC1CYP2C19CHRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260097102-A1 Treatment Of Respiratory Disorders With Arachidonate 15-Lipoxygenase (ALOX15) Inhibitors REGENERON PHARMA (US) 2026-04-09 US disclosed
US-12472241-B2 Treatment of respiratory disorders with arachidonate 15-lipoxygenase (ALOX15) inhibitors REGENERON PHARMACEUTICALS, INC. (US) 2025-11-18 US disclosed
WO-2025041465-A1 METHOD FOR CONCENTRATING IONIC CHEMICAL SPECIES AND LIPID PARTICLE 国立大学法人京都工芸繊維大学 2025-02-27 WO disclosed
US-20240074995-A1 METHODS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH AN ABNORMAL INFLAMMATORY RESPONSES FIRST WAVE BIO, INC. 2024-03-07 US disclosed
US-11793777-B2 Methods and compositions for treating conditions associated with an abnormal inflammatory response FIRST WAVE BIO, INC. (US) 2023-10-24 US disclosed
US-11744812-B2 Methods of treatment FIRST WAVE BIO, INC. (US) 2023-09-05 US disclosed
US-20230201143-A1 METHODS OF TREATMENT FIRST WAVE BIO, INC. 2023-06-29 US disclosed
US-20230102999-A1 DEUTERATED NICLOSAMIDE FIRST WAVE BIO, INC. 2023-03-30 US disclosed
US-11564896-B2 Methods of treatment FIRST WAVE BIO, INC. (US) 2023-01-31 US disclosed
EP-4045480-A1 PHARMACEUTICAL FORMULATIONS First Wave Bio, Inc. (US) 2022-08-24 EP disclosed
US-20220105057-A1 METHODS OF TREATMENT FIRST WAVE BIO, INC. 2022-04-07 US disclosed
US-20220079897-A1 METHODS OF TREATMENT FIRST WAVE BIO, INC. 2022-03-17 US disclosed
US-20220047505-A1 Controlled Absorption Water-Soluble Pharmaceutically Active Organic Compound Formulation for Once-Daily Administration STI PHARMA, LLC (US) 2022-02-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240074995-A1 METHODS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH AN ABNORMAL INFLAMMATORY RESPONSES FH, CS, ECHS1 CHRM2 2534/4885BLM 2326/4885PABPC1 4331/4885
US-20220079897-A1 METHODS OF TREATMENT ACE2, ACE, SI CHRM2 315/4885BLM 416/4885PABPC1 4034/4885
US-11744812-B2 Methods of treatment ACE2, ACE, SI CHRM2 315/4885BLM 416/4885PABPC1 4034/4885
US-20230201143-A1 METHODS OF TREATMENT ACE2, ACE, SI CHRM2 531/4885BLM 257/4885PABPC1 3943/4885
US-11564896-B2 Methods of treatment ACE2, ACE, SI CHRM2 531/4885BLM 257/4885PABPC1 3943/4885
US-20220105057-A1 METHODS OF TREATMENT ACE2, ACE, SI CHRM2 531/4885BLM 257/4885PABPC1 3943/4885
US-20230102999-A1 DEUTERATED NICLOSAMIDE FH, IDH2, ECHS1 CHRM2 2161/4885BLM 2823/4885PABPC1 4654/4885
US-20260097102-A1 Treatment Of Respiratory Disorders With Arachidonate 15-Lipoxygenase (ALOX15) Inhibitors ALOX15, ALOX15B, ALOX5 CHRM2 4475/4885BLM 924/4885PABPC1 270/4885
US-11793777-B2 Methods and compositions for treating conditions associated with an abnormal inflammatory response FH, CS, ECHS1 CHRM2 2594/4885BLM 2433/4885PABPC1 4291/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.