Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | RORC | P51449 | 3/20 | 0.46 |
| ▸ | NR1H3 | Q13133 | 10/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.44 |
| ▸ | MLYCD | O95822 | 5/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | RORA | P35398 | 1/20 | 0.41 |
| ▸ | RORB | Q92753 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22638579 | 0.78 | CA2 (0.41) | SMN1; SMN2 | |
| SCHEMBL11411032 | 0.72 | LMNA (0.69) | LMNAHTTNPSR1SMN1; SMN2RORC | |
| SCHEMBL4918537 | 0.69 | TP53 (0.50) | LMNASMN1; SMN2 | |
| SCHEMBL2968367 | 0.68 | MMP2 (0.41) | LMNA | |
| SCHEMBL8588375 | 0.68 | MIF (0.38) | GAAMAPK1 | |
| SCHEMBL22032969 | 0.68 | ALDH1A1 (0.44) | LMNAHTTNPSR1SMN1; SMN2GAA | |
| SCHEMBL272401 | 0.67 | KIF11 (0.40) | LMNAHTTNPSR1NR1H3NR1H2 | |
| SCHEMBL2378054 | 0.67 | SMN1; SMN2 (0.39) | LMNAHTTNPSR1SMN1; SMN2NR1H3 | |
| SCHEMBL27498638 | 0.67 | MT-CO2 (0.48) | LMNASMN1; SMN2 | |
| SCHEMBL11409285 | 0.67 | MLYCD (0.49) | LMNASMN1; SMN2RORCNR1H3NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4503232-B2 | — | — | 2010-07-14 | — | — | JP | claimed |
| JP-2004521113-A | — | — | 2004-07-15 | — | — | JP | claimed |
| EP-1353662-A2 | METHODS FOR THE TREATMENT OF DISEASES USING MALONYL-COA DECARBOX YLASE INHIBITORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-10-22 | — | — | EP | claimed |
| WO-2002058690-A2 | METHODS FOR THE TREATMENT OF DISEASES USING MALONYL-COA DECARBOX YLASE INHIBITORS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2002-08-01 | — | — | WO | claimed |