Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGF1 known ✓ | P05230 | 2/20 | 0.49 |
| ▸ | SERPINC1 known ✓ | P01008 | 1/20 | 0.47 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.41 |
| ▸ | HPSE | Q9Y251 | 5/20 | 0.49 |
| ▸ | LGALS3 | P17931 | 2/20 | 0.49 |
| ▸ | BMP2 | P12643 | 2/20 | 0.48 |
| ▸ | VEGFA | P15692 | 2/20 | 0.48 |
| ▸ | CXCL12 | P48061 | 2/20 | 0.48 |
| ▸ | SHH | Q15465 | 2/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.47 |
| ▸ | LGALS4 | P56470 | 1/20 | 0.47 |
| ▸ | CD69 | Q07108 | 1/20 | 0.44 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.44 |
| ▸ | IFNG | P01579 | 1/20 | 0.44 |
| ▸ | PF4 | P02776 | 1/20 | 0.44 |
| ▸ | CCL2 | P13500 | 1/20 | 0.44 |
| ▸ | SELP | P16109 | 1/20 | 0.44 |
| ▸ | BMP6 | P22004 | 1/20 | 0.44 |
| ▸ | CCL11 | P51671 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9906079 | 0.92 | LGALS3 (0.47) | HPSELGALS3BMP2VEGFACXCL12 | |
| SCHEMBL25924399 | 0.92 | LGALS3 (0.47) | HPSELGALS3BMP2VEGFACXCL12 | |
| SCHEMBL16623683 | 0.92 | LGALS3 (0.47) | HPSELGALS3BMP2VEGFACXCL12 | |
| SCHEMBL16433860 | 0.92 | LGALS3 (0.47) | HPSELGALS3BMP2VEGFACXCL12 | |
| SCHEMBL20390690 | 0.92 | LGALS3 (0.47) | HPSELGALS3BMP2VEGFACXCL12 | |
| SCHEMBL18202527 | 0.92 | LGALS3 (0.47) | HPSELGALS3BMP2VEGFACXCL12 | |
| SCHEMBL16802126 | 0.92 | LGALS3 (0.47) | HPSELGALS3BMP2VEGFACXCL12 | |
| SCHEMBL18024607 | 0.92 | LGALS3 (0.47) | HPSELGALS3BMP2VEGFACXCL12 | |
| SCHEMBL14597949 | 0.92 | LGALS3 (0.47) | HPSELGALS3BMP2VEGFACXCL12 | |
| SCHEMBL24277317 | 0.89 | LGALS3 (0.55) | LGALS3LGALS8LGALS4CD69CHIA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240058456-A1 | MOLECULES WITH SOLUBILITY TAG AND RELATED METHODS | MERCK KGAA (DE) | 2024-02-22 | — | — | US | disclosed |
| EP-4213884-A1 | MOLECULES WITH SOLUBILITY TAG AND RELATED METHODS | Merck Patent GmbH (DE) | 2023-07-26 | — | — | EP | disclosed |
| WO-2022058548-A1 | MOLECULES WITH SOLUBILITY TAG AND RELATED METHODS | MERCK PATENT GMBH (DE) | 2022-03-24 | — | — | WO | disclosed |
| EP-3970752-A1 | MOLECULES WITH SOLUBILITY TAG AND RELATED METHODS | Merck Patent GmbH (DE) | 2022-03-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240058456-A1 | MOLECULES WITH SOLUBILITY TAG AND RELATED METHODS | STT3B, STT3A, CD2BP2 | FGF1 4231/4885SERPINC1 2835/4885THRB 3844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.