Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PPID | Q08752 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6325947 | 0.85 | RIPK1 (0.50) | RIPK1ALDH1A1MAPTEPHX2CYP3A4 | |
| SCHEMBL11526495 | 0.73 | RIPK1 (0.46) | RIPK1ALDH1A1MAPTCYP3A4CYP2C19 | |
| SCHEMBL28825841 | 0.71 | THRB (0.45) | RIPK1ALDH1A1CYP2C19GAAMEN1 | |
| SCHEMBL1508717 | 0.70 | RIPK1 (0.56) | RIPK1ALDH1A1MAPTCYP2C19PPID | |
| SCHEMBL2540383 | 0.70 | RIPK1 (0.56) | RIPK1ALDH1A1MAPTCYP2C19PPID | |
| SCHEMBL1508831 | 0.70 | RIPK1 (0.56) | RIPK1ALDH1A1MAPTCYP2C19PPID | |
| SCHEMBL20424191 | 0.70 | RIPK1 (0.51) | RIPK1ALDH1A1MAPTEPHX2CYP3A4 | |
| SCHEMBL28514172 | 0.70 | POLB (0.47) | ALDH1A1MAPTCYP3A4CYP2C19SMN1; SMN2 | |
| SCHEMBL14145021 | 0.69 | CYP3A4 (0.50) | RIPK1MAPTCYP3A4CYP2C19MEN1 | |
| SCHEMBL10990271 | 0.69 | RIPK1 (0.68) | RIPK1ALDH1A1MAPTEPHX2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8183336-B2 | Poly (arylene sulfide) | KUREHA CORPORATION (JP) | 2012-05-22 | — | — | US | disclosed |
| US-20100234559-A1 | POLY (ARYLENE SULFIDE) | KUREHA CORPORATION (JP) | 2010-09-16 | — | — | US | disclosed |
| US-7767783-B2 | A poly(arylene sulfide) obtained by polymerization of a sulfur source and a dihalo-aromatic compound in the presence of an alkali metal hydroxide in an organic amide solvent, the polymerization medium having a pH of 7-12.5 from the beginning to the end of the reaction; less than 800 ppm nitrogen content | KUREHA CORPORATION (JP) | 2010-08-03 | — | — | US | disclosed |
| US-7754848-B2 | Poly (arylene sulfide) and production process thereof | KUREHA CORPORATION (JP) | 2010-07-13 | — | — | US | disclosed |
| EP-1586601-B1 | PROCESS FOR PRODUCING POLYARYLENE SULFIDE | KUREHA CORP (JP) | 2009-08-26 | — | — | EP | disclosed |
| EP-1702943-B1 | POLYARYLENE SULFIDE AND PROCESS FOR PRODUCING THE SAME | KUREHA CORP (JP) | 2009-08-26 | — | — | EP | disclosed |
| US-20090156780-A1 | Poly (Arylene Sulfide) and Production Process Thereof | KAWAMA HIROHITO | 2009-06-18 | — | — | US | disclosed |
| US-7504476-B2 | Poly(arylene sulfide) and production process thereof | KUREHA CORPORATION (JP) | 2009-03-17 | — | — | US | disclosed |
| US-20070161777-A1 | Poly (arylene sulfide) and production process thereof | KUREHA CORPORATION (JP) | 2007-07-12 | — | — | US | disclosed |
| EP-1702943-A1 | POLYARYLENE SULFIDE AND PROCESS FOR PRODUCING THE SAME | Kureha Corporation (JP) | 2006-09-20 | — | — | EP | disclosed |
| US-20060074219-A1 | Polyarylene sulfide and process for producing the same | KUREHA CORPORATION (JP) | 2006-04-06 | — | — | US | disclosed |
| EP-1586601-A1 | POLYARYLENE SULFIDE AND PROCESS FOR PRODUCING THE SAME | Kureha Chemical Industry Company, Limited (JP) | 2005-10-19 | — | — | EP | disclosed |