Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 3/20 | 0.33 |
| ▸ | MMP1 | P03956 | 2/20 | 0.33 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.32 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29697284 | 0.81 | MMP1 (0.33) | MMP13MMP1 | |
| SCHEMBL29697248 | 0.79 | PMP22 (0.35) | MMP13MMP1 | |
| SCHEMBL29005236 | 0.74 | MMP13 (0.37) | MMP13MMP1HTTALDH1A1 | |
| SCHEMBL29659094 | 0.74 | MMP13 (0.33) | MMP13MMP1 | |
| SCHEMBL29697297 | 0.69 | GLI1 (0.32) | — | |
| SCHEMBL25251069 | 0.68 | P2RX7 (0.39) | — | |
| SCHEMBL29697290 | 0.66 | TP53 (0.40) | MMP13MMP1 | |
| SCHEMBL26096598 | 0.65 | ALDH1A1 (0.57) | HTTALDH1A1MEN1CYP3A4CYP2D6 | |
| SCHEMBL12236182 | 0.64 | APEX1 (0.33) | — | |
| SCHEMBL10818207 | 0.63 | MMP13 (0.36) | MMP13MMP1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4010080-A1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF CANCER | Artios Pharma Limited (GB) | 2022-06-15 | — | — | EP | disclosed |