Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.41 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.41 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | FAP | Q12884 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3019685 | 0.84 | SLC7A5 (0.37) | RAB9AKMT2AL3MBTL1LMNADPP4 | |
| SCHEMBL11651148 | 0.83 | MMP2 (0.49) | RAB9AMC4RMMP2LOXL2LMNA | |
| SCHEMBL1324063 | 0.83 | DPP4 (0.39) | RAB9AKMT2AL3MBTL1MMP2DPP4 | |
| SCHEMBL11208513 | 0.79 | ALDH1A1 (0.48) | RAB9AKMT2AMC4RMMP2LOXL2 | |
| SCHEMBL3740377 | 0.79 | ALDH1A1 (0.48) | RAB9AKMT2AMC4RMMP2LOXL2 | |
| SCHEMBL16269330 | 0.79 | ALDH1A1 (0.48) | RAB9AKMT2AMC4RMMP2LOXL2 | |
| SCHEMBL5666945 | 0.76 | MAPT (0.59) | RAB9AKMT2AMC4RMMP2LMNA | |
| SCHEMBL240405 | 0.75 | ALDH1A1 (0.62) | RAB9AKMT2AMC4RMMP2LOXL2 | |
| SCHEMBL4367409 | 0.75 | ALDH1A1 (0.62) | RAB9AKMT2AMC4RMMP2LOXL2 | |
| SCHEMBL3317059 | 0.75 | ALDH1A1 (0.62) | RAB9AKMT2AMC4RMMP2LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1595870-B1 | PROCESS FOR PRODUCING PHENYLALANINE DERIVATIVE HAVING QUINAZOLINEDIONE SKELETON AND INTERMEDIATE FOR THE SAME | AJINOMOTO KK (JP) | 2015-09-23 | — | — | EP | disclosed |
| US-8546610-B2 | Method for preparing phenylalanine derivatives having quinazoline-dione skeleton and intermediates for use in the preparation of the derivatives | AJINOMOTO CO., INC. (JP) | 2013-10-01 | — | — | US | disclosed |
| US-8318975-B2 | Methods for producing phenylalanine derivatives having a quinazolinedione skeleton and intermediates for production thereof | AJINOMOTO CO., INC. (JP) | 2012-11-27 | — | — | US | disclosed |
| EP-2103601-B1 | PROCESS FOR PRODUCTION OF PHENYLALANINE DERIVATIVES HAVING QUINAZOLINEDIONE SKELETONS AND INTERMEDIATES FOR THE PRODUCTION | AJINOMOTO KK (JP) | 2012-03-14 | — | — | EP | disclosed |
| US-20110313154-A1 | METHOD FOR PREPARING PHENYLALANINE DERIVATIVES HAVING QUINAZOLINE-DIONE SKELETON AND INTERMEDIATES FOR USE IN THE PREPARATION OF THE DERIVATIVES | AJINOMOTO CO., INC. (JP) | 2011-12-22 | — | — | US | disclosed |
| US-8058432-B2 | Method for preparing phenylalanine derivatives having quinazoline-dione skeleton and intermediates for use in the preparation of derivatives | AJINOMOTO CO., INC. (JP) | 2011-11-15 | — | — | US | disclosed |
| US-20100204505-A1 | METHODS FOR PRODUCING PHENYLALANINE DERIVATIVES HAVING A QUINAZOLINEDIONE SKELETON AND INTERMEDIATES FOR PRODUCTION THEREOF | AJINOMOTO CO. INC (JP) | 2010-08-12 | — | — | US | disclosed |
| US-7737274-B2 | Methods for producing phenylalanine derivatives having a quinazolinedione skeleton and intermediates for production thereof | AJINOMOTO CO., INC. (JP) | 2010-06-15 | — | — | US | disclosed |
| US-20090318688-A1 | METHOD FOR PREPARING PHENYLALANINE DERIVATIVES HAVING QUINAZOLINE-DIONE SKELETON AND INTERMEDIATES FOR USE IN THE PREPARATION OF DERIVATIVES | AJINOMOTO CO., INC. (JP) | 2009-12-24 | — | — | US | disclosed |
| EP-2103601-A1 | PROCESS FOR PRODUCTION OF PHENYLALANINE DERIVATIVES HAVING QUINAZOLINEDIONE SKELETONS AND INTERMEDIATES FOR THE PRODUCTION | Ajinomoto Co., Inc. (JP) | 2009-09-23 | — | — | EP | disclosed |
| US-20060009476-A1 | Methods for producing phenylalanine derivatives having a quinazolinedione skeleton and intermediates for production thereof | AJINOMOTO CO. INC (JP) | 2006-01-12 | — | — | US | disclosed |
| EP-1595870-A1 | PROCESS FOR PRODUCING PHENYLALANINE DERIVATIVE HAVING QUINAZOLINEDIONE SKELETON AND INTERMEDIATE FOR THE SAME | Ajinomoto Co., Inc. (JP) | 2005-11-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204505-A1 | METHODS FOR PRODUCING PHENYLALANINE DERIVATIVES HAVING A QUINAZOLINEDIONE SKELETON AND INTERMEDIATES FOR PRODUCTION THEREOF | ITGA4, ITGB4, ITGA5 | RAB9A 3834/4885KMT2A 1032/4885L3MBTL1 3306/4885 |
| US-20090318688-A1 | METHOD FOR PREPARING PHENYLALANINE DERIVATIVES HAVING QUINAZOLINE-DIONE SKELETON AND INTERMEDIATES FOR USE IN THE PREPARATION OF DERIVATIVES | PAH, DDC, AADAT | RAB9A 1645/4885KMT2A 759/4885L3MBTL1 3722/4885 |
| US-20060009476-A1 | Methods for producing phenylalanine derivatives having a quinazolinedione skeleton and intermediates for production thereof | ITGA4, ITGB4, ITGA5 | RAB9A 3834/4885KMT2A 1032/4885L3MBTL1 3306/4885 |
| US-20110313154-A1 | METHOD FOR PREPARING PHENYLALANINE DERIVATIVES HAVING QUINAZOLINE-DIONE SKELETON AND INTERMEDIATES FOR USE IN THE PREPARATION OF THE DERIVATIVES | PAH, DDC, ASNS | RAB9A 1381/4885KMT2A 945/4885L3MBTL1 3826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.