Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 3/20 | 0.36 |
| ▸ | CA2 known ✓ | P00918 | 3/20 | 0.36 |
| ▸ | CA12 known ✓ | O43570 | 2/20 | 0.36 |
| ▸ | ALOX5AP known ✓ | P20292 | 1/20 | 0.36 |
| ▸ | CA4 known ✓ | P22748 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27075586 | 0.88 | PRNP (0.48) | POLBPKMSMN1; SMN2PRNPNPSR1 | |
| Acetaminophen Mercapturate SCHEMBL29048126 | 0.76 | POLB (0.42) | POLBPKMSMN1; SMN2GAAALDH1A1 | |
| Acetaminophen Mercapturate SCHEMBL30547299 | 0.76 | POLB (0.42) | POLBPKMSMN1; SMN2GAAALDH1A1 | |
| Acetaminophen Mercapturate SCHEMBL3454308 | 0.76 | POLB (0.42) | POLBPKMSMN1; SMN2GAAALDH1A1 | |
| SCHEMBL10925710 | 0.73 | PTGS1 (0.52) | — | |
| SCHEMBL14003927 | 0.73 | RXFP1 (0.51) | PKMSMN1; SMN2PRNPNPSR1RXFP1 | |
| SCHEMBL14003930 | 0.71 | RXFP1 (0.43) | PRNPNPSR1RXFP1GAAALDH1A1 | |
| SCHEMBL29426352 | 0.71 | PKM (0.51) | POLBPKMSMN1; SMN2NPSR1GAA | |
| SCHEMBL11323733 | 0.71 | PKM (0.51) | POLBPKMSMN1; SMN2NPSR1GAA | |
| SCHEMBL30067269 | 0.67 | MAPT (0.41) | SMN1; SMN2NPSR1ALDH1A1MAPTCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12146155-B2 | Method for constructing human pluripotent stem cell-derived liver organoid having enhanced drug metabolic potential and liver organoid constructed by same method | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2024-11-19 | — | — | US | disclosed |
| WO-2024095178-A1 | THROMBOPOIETIN MIMETIC FOR USE IN THE TREATMENT OF ACUTE LIVER FAILURE | JANSSEN PHARMACEUTICA NV (BE) | 2024-05-10 | — | — | WO | disclosed |
| US-20240141289-A1 | METHOD FOR CONSTRUCTING HUMAN PLURIPOTENT STEM CELL-DERIVED LIVER ORGANOID HAVING ENHANCED DRUG METABOLIC POTENTIAL AND LIVER ORGANOID CONSTRUCTED BY SAME METHOD | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2024-05-02 | — | — | US | disclosed |
| CN-117720598-A | Cinnamic acid derivative and preparation method and application thereof | 华中科技大学 | 2024-03-19 | — | — | CN | disclosed |
| US-11566081-B2 | Anti-acetaminophen antibodies and acetaminophen protein adducts | BIOVENTURES, LLC (US) | 2023-01-31 | — | — | US | disclosed |
| WO-2022181880-A1 | METHOD FOR CONSTRUCTING HUMAN PLURIPOTENT STEM CELL-DERIVED LIVER ORGANOID HAVING ENHANCED DRUG METABOLIC POTENTIAL AND LIVER ORGANOID CONSTRUCTED BY SAME METHOD | 한국화학연구원 | 2022-09-01 | — | — | WO | disclosed |