Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | NOS3 | P29474 | 1/20 | 0.48 |
| ▸ | NOS2 | P35228 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18849448 | 0.94 | GAA (0.50) | GAAL3MBTL1HTTMAPTTP53 | |
| SCHEMBL23585416 | 0.90 | GAA (0.47) | GAAL3MBTL1HTTMAPTTP53 | |
| SCHEMBL3313643 | 0.86 | SMN1; SMN2 (0.52) | GAAL3MBTL1HTTMAPTTP53 | |
| SCHEMBL5249314 | 0.84 | GPR119 (0.45) | GAAL3MBTL1HTTMAPTTP53 | |
| SCHEMBL7040593 | 0.83 | L3MBTL1 (0.38) | GAAL3MBTL1HTTMAPTTP53 | |
| SCHEMBL6497279 | 0.83 | F10 (0.40) | GAAL3MBTL1HTTMAPTTP53 | |
| SCHEMBL6485850 | 0.83 | PKM (0.41) | L3MBTL1HTTTP53THRBATM | |
| SCHEMBL10372097 | 0.81 | GAA (0.50) | GAAL3MBTL1HTTMAPTTP53 | |
| SCHEMBL16376319 | 0.80 | GPR119 (0.41) | — | |
| SCHEMBL4777779 | 0.80 | RAB9A (0.46) | GAAL3MBTL1HTTTP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10252995-B2 | Method for producing 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine or salt thereof | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2019-04-09 | — | — | US | disclosed |
| US-20180065931-A1 | METHOD FOR PRODUCING 1-(4-HYDROXYPHENYL)-4-(4-TRIFLUOROMETHOXYPHENOXY)PIPERIDINE OR SALT THEREOF | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2018-03-08 | — | — | US | disclosed |
| EP-3275862-A1 | METHOD FOR PRODUCING 1-(4-HYDROXYPHENYL)-4-(4-TRIFLUOROMETHOXYPHENOXY)PIPERIDINE OR SALT THEREOF | Otsuka Pharmaceutical Co., Ltd. (JP) | 2018-01-31 | — | — | EP | disclosed |
| WO-2016158737-A1 | METHOD FOR PRODUCING 1-(4-HYDROXYPHENYL)-4-(4-TRIFLUOROMETHOXYPHENOXY)PIPERIDINE OR SALT THEREOF | 大塚製薬株式会社 | 2016-10-06 | — | — | WO | disclosed |
| US-8552188-B2 | Epoxy compound and method for manufacturing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-10-08 | — | — | US | disclosed |
| US-20130072683-A1 | EPOXY COMPOUND AND METHOD FOR MANUFACTURING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-21 | — | — | US | disclosed |
| US-8344148-B2 | Epoxy compound and method for manufacturing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-01-01 | — | — | US | disclosed |
| CN-101675044-B | Epoxy compound and process for producing the same | OTSUKA PHARMA CO LTD | 2012-10-03 | — | — | CN | disclosed |
| EP-2144899-B1 | EPOXY COMPOUND AND METHOD FOR MANUFACTURING THE SAME | OTSUKA PHARMA CO LTD (JP) | 2011-12-07 | — | — | EP | disclosed |
| US-20100217005-A1 | EPOXY COMPOUND AND METHOD FOR MANUFACTURING THE SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2010-08-26 | — | — | US | disclosed |
| CN-101675044-A | Epoxy compound and process for producing the same | OTSUKA PHARMA CO LTD | 2010-03-17 | — | — | CN | disclosed |
| US-20070135463-A1 | Bicyclic heterocycles, drugs containing said compounds, the use thereof and method for preparing same | HIMMELSBACH FRANK | 2007-06-14 | — | — | US | disclosed |
| US-6969712-B2 | Benzimidazole derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2005-11-29 | — | — | US | disclosed |
| US-20040044056-A1 | Benzimidazole derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2004-03-04 | — | — | US | disclosed |
| EP-1342717-A1 | BENZIMIDAZOLE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2003-09-10 | — | — | EP | disclosed |
| US-5919782-A | CONTAINING A 2,4-DIOXOTRIAZOLIDINE RING | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1999-07-06 | — | — | US | disclosed |
| EP-0923580-A1 | THIAZOLIDINEDIONE COMPOUNDS HAVING ANTIDIABETIC, HYPOLIPIDAEMIC, ANTIHYPERTENSIVE PROPERTIES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1999-06-23 | — | — | EP | disclosed |
| WO-1997041120-A1 | THIAZOLIDINEDIONE COMPOUNDS HAVING ANTIDIABETIC, HYPOLIPIDAEMIC, ANTIHYPERTENSIVE PROPERTIES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | DR. REDDY'S RESEARCH FOUNDATION (IN) | 1997-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180065931-A1 | METHOD FOR PRODUCING 1-(4-HYDROXYPHENYL)-4-(4-TRIFLUOROMETHOXYPHENOXY)PIPERIDINE OR SALT THEREOF | DHPS, PAH, HPD | GAA 1280/4885L3MBTL1 4350/4885HTT 72/4885 |
| US-20070135463-A1 | Bicyclic heterocycles, drugs containing said compounds, the use thereof and method for preparing same | BPHL, CYP11B2, CYP11B1 | GAA 3330/4885L3MBTL1 4869/4885HTT 1399/4885 |
| US-20130072683-A1 | EPOXY COMPOUND AND METHOD FOR MANUFACTURING THE SAME | SQLE, CYP2E1, CYP1A1 | GAA 3459/4885L3MBTL1 1803/4885HTT 4437/4885 |
| US-20040044056-A1 | Benzimidazole derivatives | GPR119, OPRL1, INSR | GAA 1713/4885L3MBTL1 683/4885HTT 1228/4885 |
| US-20100217005-A1 | EPOXY COMPOUND AND METHOD FOR MANUFACTURING THE SAME | SQLE, CYP2E1, CYP1A1 | GAA 3381/4885L3MBTL1 1854/4885HTT 4429/4885 |
| US-10252995-B2 | Method for producing 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine or salt thereof | DHPS, PAH, HPD | GAA 1280/4885L3MBTL1 4350/4885HTT 72/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.