Sugi Predict

Sugi Predict / Compounds / SCHEMBL302837

SCHEMBL302837

SCHEMBL302837

c1ccc2c(c1)Nc1cc3ccccc3cc1O2

nearest known ligand 0.68

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ ALOX5 P09917 9/20 0.68
▸ HTR2B P41595 2/20 0.44
▸ HTR7 P34969 1/20 0.44
▸ MAPT P10636 4/20 0.44
▸ GAA P10253 2/20 0.44
▸ NPSR1 Q6W5P4 2/20 0.44
▸ NPC1 O15118 1/20 0.44
▸ MAPK1 P28482 1/20 0.44
▸ RAB9A P51151 1/20 0.44
▸ NOX1 Q9Y5S8 1/20 0.44
▸ DHODH Q02127 1/20 0.43
▸ L3MBTL1 Q9Y468 2/20 0.42
▸ TDP1 Q9NUW8 1/20 0.42
▸ LMNA P02545 1/20 0.39
▸ MEN1 O00255 2/20 0.39
▸ KMT2A Q03164 2/20 0.39
▸ ALDH1A1 P00352 1/20 0.39
▸ POLB P06746 1/20 0.39
▸ TP53 P04637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30779382 1.00 ALOX5 (0.68) ALOX5HTR2BHTR7MAPTGAA
SCHEMBL22484791 0.92 ALOX5 (0.52) ALOX5HTR2BHTR7MAPTGAA
Bicarbonate SCHEMBL6265696 0.91 ALOX5 (0.62) ALOX5HTR2BHTR7MAPTGAA
Phenoxazine SCHEMBL6846406 0.90 ALOX5 (0.77) ALOX5HTR2BHTR7MAPTGAA
Phenoxazine SCHEMBL18770789 0.85 ALOX5 (0.85) ALOX5HTR2BHTR7MAPTGAA
SCHEMBL24141298 0.85 ALOX5 (0.53) ALOX5HTR2BHTR7MAPTGAA
Phenoxazine SCHEMBL29355714 0.82 ALOX5 (1.00) ALOX5HTR2BHTR7MAPTGAA
Phenoxazine SCHEMBL28844098 0.82 ALOX5 (1.00) ALOX5HTR2BHTR7MAPTGAA
Phenoxazine SCHEMBL6310178 0.82 ALOX5 (1.00) ALOX5HTR2BHTR7MAPTGAA
Phenoxazine SCHEMBL7862 0.82 ALOX5 (1.00) ALOX5HTR2BHTR7MAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 172 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3397718-A1 FLUORESCENT PARTICULATE MATERIAL L'Oréal (FR) 2018-11-07 — — EP claimed
WO-2017114877-A1 FLUORESCENT PARTICULATE MATERIAL L'OREAL (FR) 2017-07-06 — — WO claimed
US-20160145214-A1 New Family of Discriminating Molecules for Neutron and Gamma Rays and Ionic Liquids CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) 2016-05-26 — — US claimed
EP-2976330-A1 NEW FAMILY OF DISCRIMINATING MOLECULES FOR NEUTRON AND GAMMA RAYS AND IONIC LIQUIDS Centre National de la Recherche Scientifique (C.N.R.S.) (FR) 2016-01-27 — — EP claimed
EP-2638126-B1 NEGATIVE DISPERSION RETARDATION PLATE AND ACHROMATIC CIRCULAR POLARIZER CRYSOPTIX KK (JP) 2015-02-18 — — EP claimed
WO-2014147078-A1 NEW FAMILY OF DISCRIMINATING MOLECULES FOR NEUTRON AND GAMMA RAYS AND IONIC LIQUIDS CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) (FR) 2014-09-25 — — WO claimed
EP-1781675-B1 PHOSPHONATE FLUORESCENT DYES AND CONJUGATES EPOCH BIOSCIENCES INC (US) 2014-03-26 — — EP claimed
EP-2331655-B1 COMPOSITION OF ORGANIC COMPOUNDS, OPTICAL FILM AND METHOD OF PRODUCTION THEREOF CRYSOPTIX KK (JP) 2013-07-03 — — EP claimed
JP-2012500860-A — — 2012-01-12 — — JP claimed
US-7671218-B2 Phosphonate fluorescent dyes and conjugates Elitech Holdings B.V. (NL) 2010-03-02 — — US claimed
WO-2006020947-A2 PHOSPHONATE FLUORESCENT DYES AND CONJUGATES EPOCH BIOSCIENCES, INC. (US) 2006-02-23 — — WO claimed
WO-2006008239-A2 LUMINESCENT SILICON OXIDE FLAKES CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2006-01-26 — — WO claimed
US-20050176066-A1 Compounds and methods for fluorescent labeling EPOCH BIOSCIENCES, INC. (US) 2005-08-11 — — US claimed
US-20050171340-A1 COMPOUNDS AND METHODS FOR FLUORESCENT LABELING EPOCH BIOSCIENCES, INC. (US) 2005-08-04 — — US claimed
US-20050159606-A1 Compounds and methods for fluorescent labeling EPOCH BIOSCIENCES, INC. (US) 2005-07-21 — — US claimed
WO-2005040357-A2 COMPOUNDS AND METHODS FOR FLUORESCENT LABELING EPOCH BIOSCIENCES, INC. (US) 2005-05-06 — — WO claimed
EP-1466176-A2 COMPOUNDS AND METHODS FOR FLUORESCENT LABELING Epoch Biosciences, Inc. (US) 2004-10-13 — — EP claimed
US-20030152518-A1 Detection by increased uptake of fluorophore glucose or deoxyglucose conjugates in cancerous and pre-cancerous cells relative to normal cells. THRESHOLD PHARMACEUTICALS, INC. 2003-08-14 — — US claimed
WO-2003059149-A2 METHODS FOR CANCER IMAGING THRESHOLD PHARMACEUTICALS, INC. (US) 2003-07-24 — — WO claimed
WO-2003023357-A2 COMPOUNDS AND METHODS FOR FLUORESCENT LABELING EPOCH BIOSCIENCES, INC. (US) 2003-03-20 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030152518-A1 Detection by increased uptake of fluorophore glucose or deoxyglucose conjugates in cancerous and pre-cancerous cells relative to normal cells. SLC2A1, SLC2A4, SLC2A8 ALOX5 4375/4885HTR2B 3390/4885HTR7 1952/4885
US-20050176066-A1 Compounds and methods for fluorescent labeling HLCS, GLB1, TUBB ALOX5 1685/4885HTR2B 1820/4885HTR7 1303/4885
US-20050171340-A1 COMPOUNDS AND METHODS FOR FLUORESCENT LABELING HLCS, GLB1, TUBB ALOX5 1685/4885HTR2B 1820/4885HTR7 1303/4885
US-20160145214-A1 New Family of Discriminating Molecules for Neutron and Gamma Rays and Ionic Liquids XRCC5, XRCC6, KPNA3 ALOX5 4669/4885HTR2B 4764/4885HTR7 4597/4885
US-20050159606-A1 Compounds and methods for fluorescent labeling TFEB, HLCS, PFAS ALOX5 2235/4885HTR2B 1486/4885HTR7 1032/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.