Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | CTSG | P08311 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15023628 | 0.85 | TSHR (0.43) | TSHRACHERAPGEF4KAT6AALDH1A1 | |
| Potassium Ion SCHEMBL5338570 | 0.83 | TSHR (0.41) | TSHRACHERAPGEF4KAT6AALDH1A1 | |
| SCHEMBL5157326 | 0.83 | MAPT (0.41) | TSHRACHERAPGEF4KAT6AALDH1A1 | |
| SCHEMBL6050310 | 0.81 | KMT2A (0.45) | TSHRACHEALDH1A1L3MBTL1TDP1 | |
| SCHEMBL29468592 | 0.79 | ALDH1A1 (0.55) | TSHRACHERAPGEF4ALDH1A1KDM4E | |
| SCHEMBL4533183 | 0.79 | TSHR (0.47) | TSHRACHERAPGEF4KAT6AALDH1A1 | |
| SCHEMBL475089 | 0.79 | ALDH1A1 (0.55) | TSHRACHERAPGEF4ALDH1A1KDM4E | |
| Water SCHEMBL3917281 | 0.78 | MYC (0.52) | TSHRACHERAPGEF4KAT6AALDH1A1 | |
| Water SCHEMBL8126703 | 0.78 | MYC (0.52) | TSHRACHERAPGEF4KAT6AALDH1A1 | |
| Water SCHEMBL1739275 | 0.78 | MYC (0.52) | TSHRACHERAPGEF4KAT6AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1527 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8859777-B2 | 4-fluoro-4-arylpiperdin-1-yl derivatives as mu opioid function moderators | KINENTIA BIOSCIENCES LLC (US) | 2014-10-14 | — | — | US | claimed |
| US-8765780-B2 | Alicyclic carboxylic acid derivatives of benzomorphans and related scaffolds, medicaments containing such compounds and their use | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-07-01 | — | — | US | claimed |
| US-20130045165-A1 | 4-FLUORO-4-ARYLPIPERDIN-1-YL DERIVATIVES AS MU OPIOID FUNCTION MODERATORS | KINENTIA BIOSCIENCES, LLC (US) | 2013-02-21 | — | — | US | claimed |
| WO-2011137331-A2 | 4-FLUORO-4-ARYLPIPERDIN-1-YL DERIVATIVES AS MU OPIOID FUNCTION MODERATORS | KINENTIA BIOSCIENCES LLC (US) | 2011-11-03 | — | — | WO | claimed |
| US-20080200454-A1 | CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. | 2008-08-21 | — | — | US | claimed |
| WO-2008100618-A2 | CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | SUNESIS PHARMACEUTICALS, INC. (US) | 2008-08-21 | — | — | WO | claimed |
| EP-0938486-B1 | SUBSTITUTED PYRROLOPYRIMIDINES AND PROCESSES FOR THEIR PREPARATION | NOVARTIS AG (CH) | 2008-01-16 | — | — | EP | claimed |
| US-7179832-B2 | Glycogen synthase kinase 3β inhibitor, composition and process for the preparation thereof | CRYSTALGENOMICS, INC. (KR) | 2007-02-20 | — | — | US | claimed |
| EP-0774461-B1 | Excitatory amino acid derivatives | LILLY CO ELI (US) | 2006-03-08 | — | — | EP | claimed |
| EP-1311501-B1 | ANTITHROMBOTIC AGENTS | LILLY CO ELI (US) | 2005-11-02 | — | — | EP | claimed |
| US-4670421-A | ANTICHOLESTEROL AGENTS | AMERICAN CYANAMID COMPANY (US) | 1987-06-02 | — | — | US | claimed |
| EP-0062902-B1 | 2,3,4-TRINOR-M-INTER-PHENYLENE-PROSTAGLANDIN DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | CHINOIN Gyogyszer és Vegyészeti Termékek Gyára RT. (HU) | 1986-01-15 | — | — | EP | claimed |
| US-4241056-A | ANTIBIOTICS | BOEHRINGER INGELHEIM GMBH (DE) | 1980-12-23 | — | — | US | claimed |
| US-4122089-A | Aminothiofluoran compounds, process for the production thereof, and recording elements containing the same | SANKIO CHEMICAL CO., LTD. (JP) | 1978-10-24 | — | — | US | claimed |
| US-4105665-A | MONOMETHINE DYESTUFFS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-08-08 | — | — | US | claimed |
| US-4081446-A | DEHALOGENATION, AMMONIATION | HOECHST AKTIENGESELLSCHAFT (DT) | 1978-03-28 | — | — | US | claimed |
| US-4036824-A | Disazo dyestuffs containing A-O-alkylene-O-SO3 H group | BAYER AKTIENGESELLSCHAFT (DT) | 1977-07-19 | — | — | US | claimed |
| US-4018796-A | FIBERS | BAYER AKTIENGESELLSCHAFT (DT) | 1977-04-19 | — | — | US | claimed |
| US-3980673-A | INSECTICIDES, ACARICIDES | BAYER AKTIENGESELLSCHAFT (DT) | 1976-09-14 | — | — | US | claimed |
| US-3966703-A | Asymmetrical frisazo dyestuffs derived from diazotized 2,7-diamino-carbazole | BAYER AKTIENGESELLSCHAFT (DT) | 1976-06-29 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200454-A1 | CARBON-LINKED TETRAHYDRO-PYRAZOLO-PYRIDINE MODULATORS OF CATHEPSIN S | CTSS, CTSK, CTSZ | TSHR 3648/4885ACHE 1547/4885RAPGEF4 1618/4885 |
| US-20130045165-A1 | 4-FLUORO-4-ARYLPIPERDIN-1-YL DERIVATIVES AS MU OPIOID FUNCTION MODERATORS | OPRD1, OPRK1, OPRM1 | TSHR 282/4885ACHE 644/4885RAPGEF4 2732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.