Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA known ✓ | P25101 | 1/20 | 0.39 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL5338570 | 0.95 | TSHR (0.41) | MAPTTSHRACHERAPGEF4KAT6A | |
| SCHEMBL305238 | 0.83 | TSHR (0.43) | MAPTTSHRACHERAPGEF4KAT6A | |
| SCHEMBL4533183 | 0.77 | TSHR (0.47) | MAPTTSHRACHERAPGEF4KAT6A | |
| SCHEMBL475089 | 0.77 | ALDH1A1 (0.55) | MAPTTSHRACHERAPGEF4ALDH1A1 | |
| SCHEMBL29468592 | 0.77 | ALDH1A1 (0.55) | MAPTTSHRACHERAPGEF4ALDH1A1 | |
| SCHEMBL16034284 | 0.76 | TDP1 (0.45) | MAPTTSHRACHERAPGEF4ALDH1A1 | |
| Water SCHEMBL9476427 | 0.76 | ALDH1A1 (0.42) | MAPTTSHRACHERAPGEF4ALDH1A1 | |
| Water SCHEMBL3917281 | 0.76 | MYC (0.52) | TSHRACHERAPGEF4KAT6AALDH1A1 | |
| SCHEMBL57931 | 0.76 | TDP1 (0.45) | MAPTTSHRACHERAPGEF4ALDH1A1 | |
| Water SCHEMBL1739275 | 0.76 | MYC (0.52) | TSHRACHERAPGEF4KAT6AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1103848-B1 | Light-sensitive silver halide photographic film material and radiographic intensifying screen-film combination | AGFA GEVAERT (BE) | 2007-01-17 | — | — | EP | disclosed |
| EP-0874275-B1 | Photographic silver halide material for mammography | AGFA GEVAERT (BE) | 2006-11-02 | — | — | EP | disclosed |
| US-7129031-B2 | Radiographic silver halide photographic material having a good developing speed, an excellent image tone and low residual color after processing | AGFA-GEVAERT (BE) | 2006-10-31 | — | — | US | disclosed |
| EP-1103850-B1 | Radiographic film material exhibiting increased covering power and \"colder\" blue-black image tone | AGFA GEVAERT (BE) | 2006-07-19 | — | — | EP | disclosed |
| US-20050191589-A1 | Radiographic silver halide photographic material having a good developing speed, an excellent image tone and low residual color after processing | AGFA HEALTHCARE (BE) | 2005-09-01 | — | — | US | disclosed |
| US-6472137-B1 | Light-sensitive silver halide photographic film material and radiographic intensifying screen-film combination | AGFA-GEVAERT (BE) | 2002-10-29 | — | — | US | disclosed |
| EP-1103847-B1 | Silver halide photographic film material exhibiting increased covering power and \"colder\" blue-black image tone | AGFA GEVAERT (BE) | 2002-09-11 | — | — | EP | disclosed |
| EP-0945755-B1 | A photosensitive image-forming element containing silver halide cristals internally modified with a metal-halogen-fluorine complex | AGFA GEVAERT (BE) | 2002-06-05 | — | — | EP | disclosed |
| US-6346360-B1 | ANTISTRESS LAYER COMPRISING 5-MERCAPTO-1H-TETRAZOLE DERIVATIVE; LIGHT SENSITIVE SILVER HALIDE EMULSION FILM, INTENSIFYING SCREEN AND LUMINESCENT PHOSPHOR | AGFA-GEVAERT (BE) | 2002-02-12 | — | — | US | disclosed |
| US-6342338-B1 | BLACK-AND-WHITE LIGHT PHOTOGRAPHIC FILM MATERIAL FOR USE IN RADIOGRAPHY AND A COMBINATION INTENSIFYING LUMINESCENT PHOSPHOR SCREEN; HEXAGONAL TABULAR EMULSION GRAINS; PROTECTIVE ANTISTRESS LAYER CONTAINING A HETEROCYCLIC AMINE COMPOUND | AGFA-GEVAERT (BE) | 2002-01-29 | — | — | US | disclosed |
| EP-1061414-A1 | Developer composition for use in the processing of light-sensitive silver halide photographic materials | AGFA-GEVAERT N.V. (BE) | 2000-12-20 | — | — | EP | disclosed |
| US-6159679-A | Photosensitive image-forming element containing internally modified silver halide crystals | AGFA-GEVAERT, N.V. (BE) | 2000-12-12 | — | — | US | disclosed |
| EP-1058150-A1 | Shallow electron trap dopants in silver halide tabular grain emulsions for use in medical diagnostic imaging materials | AGFA-GEVAERT N.V. (BE) | 2000-12-06 | — | — | EP | disclosed |
| EP-1045283-A1 | Radiation-sensitive emulsion, light-sensitive silver halide photographic film material and radiographic intensifying screen-film combination | AGFA-GEVAERT N.V. (BE) | 2000-10-18 | — | — | EP | disclosed |
| US-5965318-A | CHARACTERIZED IN THE SENSIOMETRIC CURVE OF OPTICAL DENSITY VERSUS RELATIVE LOGARITHMIC EXPOSURE; HIGH CONTRAST AND LARGE DYNAMIC RANGE SO SMALL LESIONS DEEP IN TISSUE ARE DETECTED, BUT ALSO CLEAR DEPICTION OF SKIN LINE OF THE BREAST; RAPID | AGFA-GEVAERT, N.V. (BE) | 1999-10-12 | — | — | US | disclosed |
| EP-0945755-A1 | A photosensitive image-forming element containing silver halide cristals internally modified with a metal-halogen-fluorine complex | AGFA-GEVAERT N.V. (BE) | 1999-09-29 | — | — | EP | disclosed |
| EP-0933670-A1 | Light-sensitive emulsion having tabular grains rich in silver bromide doped with thiocyanate complexes of rhodium | AGFA-GEVAERT N.V. (BE) | 1999-08-04 | — | — | EP | disclosed |
| EP-0933671-A1 | A photosensitive image-forming element containing silver halide crystals which are internally modified with a metal ligand complex forming deep electron traps | AGFA-GEVAERT N.V. (BE) | 1999-08-04 | — | — | EP | disclosed |
| EP-0874275-A1 | Photographic silver halide material for mammography | AGFA-GEVAERT N.V. (BE) | 1998-10-28 | — | — | EP | disclosed |
| EP-0862084-A1 | Photosensitive image-forming element containing internally modified silver halide crystals | AGFA-GEVAERT N.V. (BE) | 1998-09-02 | — | — | EP | disclosed |