SCHEMBL30656170

SCHEMBL30656170

Cc1sc2ccc(OCc3cccnc3C(F)(F)F)cc2c1C(=O)NC1CCNC1=O

nearest known ligand 0.40

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HPGDS O60760 6/20 0.40
APOL1 O14791 1/20 0.37
MGAT2 Q10469 1/20 0.33
NMT1 P30419 1/20 0.33
NPC1 O15118 3/20 0.33
RAB9A P51151 3/20 0.33
SCN9A Q15858 2/20 0.33
GPR52 Q9Y2T5 2/20 0.32
FGFR1 P11362 2/20 0.32
CD38 P28907 1/20 0.32
FGFR3 P22607 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30656145 0.86 APOL1 (0.42) HPGDSAPOL1SCN9A
SCHEMBL29630137 0.85 SLC26A4 (0.45) HPGDS
SCHEMBL24485616 0.85 SLC26A4 (0.45) HPGDS
SCHEMBL30656064 0.84 SLC6A5 (0.45)
SCHEMBL30656343 0.83 CFD (0.36) SCN9ACD38
SCHEMBL30656331 0.83 ALDH1A1 (0.38) CD38
SCHEMBL30656001 0.83 RAB9A (0.45) HPGDSNPC1RAB9ASCN9A
SCHEMBL30656206 0.83 APOL1 (0.49) HPGDSAPOL1
SCHEMBL30656337 0.82 SSTR4 (0.42)
SCHEMBL30656120 0.81 SLC26A4 (0.42) CD38

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4532013-A1 NEW DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS Katholieke Universiteit Leuven KU Leuven Research & Development (BE) 2025-04-09 EP claimed
CN-119421879-A Novel derivatives for the treatment of TRPM3 mediated disorders 勒芬天主教大学 2025-02-11 CN claimed
WO-2023227697-A1 NEW DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2023-11-30 WO claimed
EP-4532013-A1 NEW DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS Katholieke Universiteit Leuven KU Leuven Research & Development (BE) 2025-04-09 EP disclosed
CN-119421879-A Novel derivatives for the treatment of TRPM3 mediated disorders 勒芬天主教大学 2025-02-11 CN disclosed
WO-2023227697-A1 NEW DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2023-11-30 WO disclosed