SCHEMBL30656343

SCHEMBL30656343

Cc1sc2ccc(OCc3cccnc3C(F)(F)F)cc2c1C(=O)NC1CC(F)(F)C1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CFD P00746 1/20 0.36
SCN9A Q15858 2/20 0.35
CD38 P28907 1/20 0.34
SCN7A Q01118 1/20 0.34
KCNH2 Q12809 1/20 0.34
SCN5A Q14524 1/20 0.34
SCN10A Q9Y5Y9 1/20 0.34
GRM4 Q14833 3/20 0.34
DRD3 P35462 2/20 0.34
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
ALDH1A1 P00352 2/20 0.33
POLB P06746 1/20 0.33
ADAM17 P78536 1/20 0.33
DRD2 P14416 1/20 0.32
PPARG P37231 1/20 0.32
PPARD Q03181 1/20 0.32
PPARA Q07869 1/20 0.32
TRPA1 O75762 1/20 0.32
LIPG Q9Y5X9 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30656064 0.87 SLC6A5 (0.45)
SCHEMBL30656001 0.87 RAB9A (0.45) SCN9ASCN7AKCNH2SCN5AGRM4
SCHEMBL30656337 0.86 SSTR4 (0.42) DRD3DRD2
SCHEMBL30656331 0.85 ALDH1A1 (0.38) CD38MEN1KMT2AALDH1A1POLB
SCHEMBL30656233 0.85 SSTR4 (0.37) CD38ADAM17
SCHEMBL30656170 0.83 HPGDS (0.40) SCN9ACD38
SCHEMBL30656066 0.83 SCN9A (0.35) SCN9ACD38ADAM17PPARGPPARD
SCHEMBL30656120 0.83 SLC26A4 (0.42) CD38MEN1KMT2APOLBPPARG
SCHEMBL30656073 0.82 EDNRA (0.47) MEN1KMT2AALDH1A1KDM4E
SCHEMBL30656226 0.82 CD38 (0.37) SCN9ACD38OPRL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4532013-A1 NEW DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS Katholieke Universiteit Leuven KU Leuven Research & Development (BE) 2025-04-09 EP claimed
CN-119421879-A Novel derivatives for the treatment of TRPM3 mediated disorders 勒芬天主教大学 2025-02-11 CN claimed
WO-2023227697-A1 NEW DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2023-11-30 WO claimed
EP-4532013-A1 NEW DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS Katholieke Universiteit Leuven KU Leuven Research & Development (BE) 2025-04-09 EP disclosed
CN-119421879-A Novel derivatives for the treatment of TRPM3 mediated disorders 勒芬天主教大学 2025-02-11 CN disclosed
WO-2023227697-A1 NEW DERIVATIVES FOR TREATING TRPM3 MEDIATED DISORDERS KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2023-11-30 WO disclosed