Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.32 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.31 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.31 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.31 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5157594 | 0.98 | RXRA (0.34) | ALDH1A1RAB9ARXRARXRBKDM4E | |
| SCHEMBL29738939 | 0.89 | SLC22A2 (0.46) | PABPC1APOBEC3AEIF4HAPOBEC3GSLC22A2 | |
| SCHEMBL7196197 | 0.89 | SLC22A2 (0.32) | RXRARXRBSLC22A2SLC22A1SLC22A3 | |
| SCHEMBL17996987 | 0.81 | RAPGEF4 (0.38) | RXRARXRB | |
| Hydrochloric Acid SCHEMBL2460511 | 0.80 | ALDH1A1 (0.67) | ALDH1A1RAB9AKDM4E | |
| SCHEMBL12267697 | 0.80 | TPMT (0.52) | ALDH1A1RXRARXRBKDM4ERCE1 | |
| Hydrochloric Acid SCHEMBL2469434 | 0.78 | RAB9A (0.42) | ALDH1A1RAB9AKDM4EPABPC1APOBEC3A | |
| Hydrochloric Acid SCHEMBL3930213 | 0.78 | FDPS (0.32) | ALDH1A1KDM4E | |
| SCHEMBL12267700 | 0.75 | ACHE (0.43) | ALDH1A1RAB9AKDM4EACHESLC22A2 | |
| Hydrochloric Acid SCHEMBL2469452 | 0.74 | RAB9A (0.33) | ALDH1A1RAB9AKDM4EPABPC1APOBEC3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100091353-A1 | DISPLAY ELEMENT AND METHOD OF DRIVING THE SAME | KONICA MINOLTA HOLDINGS, INC. (JP) | 2010-04-15 | — | — | US | disclosed |
| EP-2096490-A1 | DISPLAY ELEMENT AND METHOD OF DRIVING THE SAME | Konica Minolta Holdings, Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |