Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.55 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.55 |
| ▸ | ITGAV | P06756 | 1/20 | 0.55 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.55 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.55 |
| ▸ | ACE | P12821 | 3/20 | 0.53 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552264 | 1.00 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2ITGB3ITGB1ITGAV | |
| SCHEMBL5966137 | 0.95 | FKBP1A (0.57) | ALDH1A1SMN1; SMN2ITGB3ITGB1ITGAV | |
| SCHEMBL5966186 | 0.95 | FKBP1A (0.57) | ALDH1A1SMN1; SMN2ITGB3ITGB1ITGAV | |
| SCHEMBL5966141 | 0.95 | FKBP1A (0.57) | ALDH1A1SMN1; SMN2ITGB3ITGB1ITGAV | |
| SCHEMBL14407796 | 0.94 | FKBP1A (0.56) | ALDH1A1SMN1; SMN2ITGB3ITGB1ITGAV | |
| SCHEMBL7247533 | 0.90 | FKBP1A (0.45) | ALDH1A1SMN1; SMN2ITGB3ITGB1ITGAV | |
| SCHEMBL14407859 | 0.86 | ALOX5 (0.54) | ALDH1A1SMN1; SMN2ITGB3ITGB1ITGAV | |
| SCHEMBL6079299 | 0.84 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2ITGB3ITGB1ITGAV | |
| SCHEMBL14407821 | 0.84 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2ITGB3ITGB1ITGAV | |
| SCHEMBL13230 | 0.83 | CA2 (0.67) | ALDH1A1SMN1; SMN2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076817-A1 | Small Molecule Rotamase Enzyme Inhibitors | HAMILTON GREGORY S | 2008-03-27 | — | — | US | claimed |
| EP-1227859-B1 | NEUROPHILIN LIGANDS FOR TREATING OCULAR CONDITIONS | ALCON INC (CH) | 2006-08-09 | — | — | EP | claimed |
| US-20050272780-A1 | Small molecule inhibitors of rotamase enzyme activity | GUILFORD NIL HOLDINGS, INC. | 2005-12-08 | — | — | US | claimed |
| US-6943187-B2 | Pyrrolidine derivative hair growth compositions and uses | GPI NIL HOLDINGS, INC. (US) | 2005-09-13 | — | — | US | claimed |
| US-20040186098-A1 | Method for preventing and treating hearing loss using sensorineurotrophic compounds | AMGEN INC. | 2004-09-23 | — | — | US | claimed |
| US-20020198250-A1 | Pyrrolidine derivative hair growth compositions and uses | GLIAMED, INC. | 2002-12-26 | — | — | US | claimed |
| US-20010049381-A1 | Pyrrolidine derivative hair growth compositions and uses | GPL NIL HOLDINGS, INC., | 2001-12-06 | — | — | US | claimed |
| US-20010034362-A1 | Pyrrolidine derivatives for vision and memory disorders | GUILFORD PHARMACEUTICALS INC. (US) | 2001-10-25 | — | — | US | claimed |
| US-20010029263-A1 | Novel pyrrolidine carboxylate hair revitalizing agents | GPI NIL HOLDINGS, INC. | 2001-10-11 | — | — | US | claimed |
| US-6218423-B1 | ADMINISTERING PYRROLIDINE DERIVATIVE FOR THERAPY OF NERVE-RELATED VISION DISORDER, IMPROVING VISION, TREATING MEMORY IMPAIRMENT, OR ENHANCING MEMORY PERFORMANCE IN ANIMAL | GPI NIL HOLDINGS, INC. | 2001-04-17 | — | — | US | claimed |
| US-6177455-B1 | ADMINISTERING A NITROGEN-CONTAINING HETEROCYCLIC COMPOUND | GPI NIL HOLDINGS, INC. | 2001-01-23 | — | — | US | claimed |
| EP-0769006-B1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARM INC (US) | 2000-11-08 | — | — | EP | claimed |
| EP-0992492-A1 | Small molecule inhibitors of rotamase enzyme activity | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-12 | — | — | EP | claimed |
| US-5614547-A | Small molecule inhibitors of rotamase enzyme | GUILFORD PHARMACEUTICALS INC. (US) | 1997-03-25 | — | — | US | claimed |
| WO-1996040633-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1996-12-19 | — | — | WO | claimed |
| US-20100145071-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GLIAMED, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| EP-1433781-B1 | Pyrrolidine carboxylic acid derivatives | MGI GP INC (US) | 2010-02-24 | — | — | EP | disclosed |
| US-5795908-A | FKBP IMMUNOPHILINS FOR ENZYME INHIBITORS | GPI NIL HOLDINGS, INC. (US) | 1998-08-18 | — | — | US | disclosed |
| US-5614547-A | Small molecule inhibitors of rotamase enzyme | GUILFORD PHARMACEUTICALS INC. (US) | 1997-03-25 | — | — | US | disclosed |
| WO-1996040633-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1996-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186098-A1 | Method for preventing and treating hearing loss using sensorineurotrophic compounds | GAP43, CHAT, MYOC | ALDH1A1 508/4885SMN1; SMN2 2678/4885ITGB3 4050/4885 |
| US-20100145071-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | FKBP8, FKBP1A, FKBP2 | ALDH1A1 2906/4885SMN1; SMN2 2314/4885ITGB3 4625/4885 |
| US-20050272780-A1 | Small molecule inhibitors of rotamase enzyme activity | FKBP8, FKBP1A, PREP | ALDH1A1 3358/4885SMN1; SMN2 2456/4885ITGB3 4696/4885 |
| US-20020198250-A1 | Pyrrolidine derivative hair growth compositions and uses | MKI67, PLOD2, HDGF | ALDH1A1 757/4885SMN1; SMN2 4826/4885ITGB3 4795/4885 |
| US-20010034362-A1 | Pyrrolidine derivatives for vision and memory disorders | PDE6D, PDE6C, PDE4D | ALDH1A1 2196/4885SMN1; SMN2 1647/4885ITGB3 4874/4885 |
| US-20080076817-A1 | Small Molecule Rotamase Enzyme Inhibitors | FKBP8, FKBP1A, FKBP2 | ALDH1A1 3064/4885SMN1; SMN2 2061/4885ITGB3 4725/4885 |
| US-20010029263-A1 | Novel pyrrolidine carboxylate hair revitalizing agents | PDCD1, PDCD4, PDCD5 | ALDH1A1 1810/4885SMN1; SMN2 4843/4885ITGB3 4822/4885 |
| US-20010049381-A1 | Pyrrolidine derivative hair growth compositions and uses | MKI67, PLOD2, HDGF | ALDH1A1 757/4885SMN1; SMN2 4826/4885ITGB3 4795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.