SCHEMBL316509

SCHEMBL316509

C=Cc1ccc(COCCCCCCOc2ccc3c(c2)C(=O)N([C@H](C(=O)OC(C)(C)C)C(C)(C)C)C3=O)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 6/20 0.35
▸ BACE1 P56817 1/20 0.33
▸ GABRA1 P14867 1/20 0.32
▸ GABRG2 P18507 1/20 0.32
▸ GABRB3 P28472 1/20 0.32
▸ GABRA5 P31644 1/20 0.32
▸ GABRA3 P34903 1/20 0.32
▸ GABRA2 P47869 1/20 0.32
▸ GABRA4 P48169 1/20 0.32
▸ GABRA6 Q16445 1/20 0.32
▸ MAPT P10636 2/20 0.31
▸ BCHE P06276 2/20 0.31
▸ ACHE P22303 2/20 0.31
▸ BCL2 P10415 3/20 0.31
▸ BCL2L2 Q92843 3/20 0.31
▸ BAD Q92934 3/20 0.31
▸ PLA2G4B P0C869 1/20 0.30
▸ PPARA Q07869 1/20 0.30
▸ KIT P10721 1/20 0.30
▸ FLT3 P36888 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL316517 0.91 L3MBTL1 (0.38) L3MBTL1BACE1MAPTBCHEACHE
SCHEMBL10037556 0.88 L3MBTL1 (0.37) L3MBTL1MAPTBCL2BCL2L2BAD
SCHEMBL316521 0.78 L3MBTL1 (0.51) L3MBTL1BCL2BCL2L2BADMEN1
SCHEMBL316315 0.71 MEN1 (0.43) GABRA1GABRG2GABRB3GABRA5GABRA3
SCHEMBL10068087 0.69 L3MBTL1 (0.49) L3MBTL1MAPTMEN1NPC1ALDH1A1
SCHEMBL315870 0.68 POLB (0.50) L3MBTL1ALDH1A1GAAKMT2A
SCHEMBL25667517 0.67 LMNA (0.43) NPC1ALDH1A1GAA
SCHEMBL18868387 0.65 ALDH1A1 (0.44) L3MBTL1ALDH1A1
SCHEMBL316600 0.64 ALDH1A1 (0.46) L3MBTL1ALDH1A1
SCHEMBL7377987 0.63 LTA4H (0.46) MAPTACHEMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2045014-B1 POLYMER-SUPPORTED METAL COMPLEX CATALYST UNIV HOKKAIDO NAT UNIV CORP (JP) 2014-01-15 — — EP disclosed
US-8092720-B2 Polymer-supported metal complex catalyst NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (JP) 2012-01-10 — — US disclosed
US-20090227743-A1 POLYMER-SUPPORTED METAL COMPLEX CATALYST NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY (JP) 2009-09-10 — — US disclosed
EP-2045014-A1 POLYMER-SUPPORTED METAL COMPLEX CATALYST National University Corporation Hokkaido University (JP) 2009-04-08 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090227743-A1 POLYMER-SUPPORTED METAL COMPLEX CATALYST PYM1, ARG1, SCO2 L3MBTL1 2735/4885BACE1 3398/4885GABRA1 2100/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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