Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 13/20 | 0.41 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4207578 | 1.00 | KCNH2 (0.41) | KCNH2RIOK2KDM4EGAAALDH1A1 | |
| SCHEMBL29743296 | 1.00 | KCNH2 (0.41) | KCNH2RIOK2KDM4EGAAALDH1A1 | |
| Water SCHEMBL30026832 | 0.99 | KCNH2 (0.41) | KCNH2RIOK2KDM4EGAAALDH1A1 | |
| SCHEMBL3424094 | 0.91 | KCNH2 (0.49) | KCNH2RIOK2KDM4EGAAALDH1A1 | |
| SCHEMBL29652162 | 0.91 | KCNH2 (0.49) | KCNH2RIOK2KDM4EGAAALDH1A1 | |
| SCHEMBL29652161 | 0.91 | KCNH2 (0.49) | KCNH2RIOK2KDM4EGAAALDH1A1 | |
| SCHEMBL1057997 | 0.91 | KCNH2 (0.49) | KCNH2RIOK2KDM4EGAAALDH1A1 | |
| SCHEMBL3173642 | 0.90 | KCNH2 (0.48) | KCNH2RIOK2KDM4EGAAALDH1A1 | |
| SCHEMBL3173652 | 0.90 | KCNH2 (0.48) | KCNH2RIOK2KDM4EGAAALDH1A1 | |
| SCHEMBL4207580 | 0.90 | KCNH2 (0.48) | KCNH2RIOK2KDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2653506-B1 | METHOD FOR PRESERVING AQUEOUS SOLUTION CONTAINING LEUCO CHROMOGEN | HITACHI CHEMICAL DIAGNOSTICS SYSTEMS CO LTD (JP) | 2021-12-08 | — | — | EP | disclosed |
| US-9176066-B2 | Method for preserving aqueous solution containing leuco chromogen | KYOWA MEDEX CO., LTD. (JP) | 2015-11-03 | — | — | US | disclosed |
| EP-2653506-A1 | METHOD FOR STORING LEUCO CHROMOGEN-CONTAINING AQUEOUS SOLUTION | Kyowa Medex Co., Ltd. (JP) | 2013-10-23 | — | — | EP | disclosed |
| US-20130252343-A1 | METHOD FOR PRESERVING AQUEOUS SOLUTION CONTAINING LEUCO CHROMOGEN | KYOWA MEDEX CO., LTD. (JP) | 2013-09-26 | — | — | US | disclosed |
| US-7648839-B2 | Metal indicator | KOWA CO., LTD. (JP) | 2010-01-19 | — | — | US | disclosed |
| US-20080057591-A1 | Metal Indicator | KOWA CO., LTD. (JP) | 2008-03-06 | — | — | US | disclosed |
| EP-1762843-A1 | METAL INDICATOR | KOWA CO. LTD. (JP) | 2007-03-14 | — | — | EP | disclosed |
| EP-0763512-A1 | AIR BAG GAS GENERATING AGENT | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1997-03-19 | — | — | EP | disclosed |
| EP-0508242-A2 | Enzyme reagent, kit, and method for determination of blood phenylalanine | CIBA CORNING DIAGNOSTICS K.K. (JP) | 1992-10-14 | — | — | EP | disclosed |