Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 18/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.58 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3236774 | 0.84 | ROCK2 (0.56) | ROCK2ROCK1 | |
| SCHEMBL3225440 | 0.78 | PRMT6 (0.56) | ROCK2ROCK1 | |
| SCHEMBL25718791 | 0.76 | ROCK2 (0.63) | ROCK2ROCK1 | |
| SCHEMBL21256985 | 0.75 | ROCK2 (0.88) | ROCK2ROCK1 | |
| SCHEMBL13626335 | 0.74 | AURKA (0.64) | ROCK2ROCK1 | |
| SCHEMBL25718947 | 0.74 | ROCK2 (0.70) | ROCK2ROCK1 | |
| SCHEMBL20113298 | 0.73 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL2980074 | 0.73 | PKM (0.68) | — | |
| SCHEMBL20113328 | 0.72 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL1928387 | 0.72 | RAB9A (0.67) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8242142-B2 | Cyclohexylamines, phenylamines and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-08-14 | — | — | US | disclosed |
| WO-2010022159-A1 | CYCLOHEXYLAMINES, PHENYLAMINES AND USES THEREOF | BIOSYNERGO (KY) | 2010-02-25 | — | — | WO | disclosed |
| US-20100048637-A1 | CYCLOHEXYLAMINES, PHENYLAMINES AND USES THEREOF | PEKING UNIVERSITY SHENZHEN GRADUATE SCHOOL (CN) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048637-A1 | CYCLOHEXYLAMINES, PHENYLAMINES AND USES THEREOF | SMO, HNMT, INMT | ROCK2 3493/4885ROCK1 3496/4885SMYD3 184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.