SCHEMBL3262971

SCHEMBL3262971

C#CCCCCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.35
SMYD2 Q9NRG4 3/20 0.35
HTT P42858 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
CYP1A2 P05177 2/20 0.32
CYP2D6 P10635 2/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
HSD17B10 Q99714 1/20 0.32
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
DRD2 P14416 1/20 0.31
MAOA P21397 2/20 0.30
MAOB P27338 2/20 0.30
ALDH1A1 P00352 1/20 0.30
ALOX15 P16050 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2480164 0.98 CYP3A4 (0.35) CYP3A4SMYD2HTTSMN1; SMN2CYP1A2
SCHEMBL2481872 0.98 CYP3A4 (0.35) CYP3A4SMYD2HTTSMN1; SMN2CYP1A2
SCHEMBL13794147 0.98 CYP3A4 (0.35) CYP3A4SMYD2HTTSMN1; SMN2CYP1A2
SCHEMBL30158833 0.98 CYP3A4 (0.35) CYP3A4SMYD2HTTSMN1; SMN2CYP1A2
SCHEMBL16878895 0.98 CYP3A4 (0.35) CYP3A4SMYD2HTTSMN1; SMN2CYP1A2
SCHEMBL13295612 0.98 CYP3A4 (0.35) CYP3A4SMYD2HTTSMN1; SMN2CYP1A2
SCHEMBL3456559 0.95 SMYD2 (0.36) CYP3A4SMYD2HTTSMN1; SMN2CYP1A2
SCHEMBL2188878 0.89 SMYD2 (0.37) CYP3A4SMYD2HTTSMN1; SMN2MEN1
SCHEMBL2484114 0.84 SMYD2 (0.35) CYP3A4SMYD2HTTSMN1; SMN2
SCHEMBL15686013 0.82 LTA4H (0.36) CYP3A4SMYD2HTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250032453-A1 20-HETE RECEPTOR (GPR75) ANTAGONISTS AND METHODS OF USE NEW YORK MEDICAL COLLEGE 2025-01-30 US disclosed
US-20240041831-A1 20-HETE RECEPTOR (GPR75) ANTAGONISTS AND METHODS OF USE NEW YORK MEDICAL COLLEGE 2024-02-08 US disclosed
US-11690825-B2 20-HETE receptor (GPR75) antagonists and methods of use BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2023-07-04 US disclosed
US-11690825-B2 20-HETE receptor (GPR75) antagonists and methods of use BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2023-07-04 US disclosed
US-20200030291-A1 20-HETE RECEPTOR (GPR75) ANTAGONISTS AND METHODS OF USE NEW YORK MEDICAL COLLEGE 2020-01-30 US disclosed
US-20180104220-A1 IMIDAZOLE COMPOUND MEDSHINE DISCOVERY INC. (CN) 2018-04-19 US disclosed
EP-3287453-A1 IMIDAZOLE COMPOUND Medshine Discovery Inc. (CN) 2018-02-28 EP disclosed
WO-2017156164-A1 20-HETE RECEPTOR (GPR75) ANTAGONISTS AND METHODS OF USE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 2017-09-14 WO disclosed
US-20170008918-A1 NOVEL CYP-EICOSANOID DERIVATIVES NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2017-01-12 US disclosed
WO-2016169514-A1 IMIDAZOLE COMPOUND 广东众生药业股份有限公司 2016-10-27 WO disclosed
US-9127027-B2 Epoxyeicosatrienoic acid analogs and methods of making and using the same THE MEDICAL COLLEGE OF WISCONSIN, INC. (US) 2015-09-08 US disclosed
US-20140113884-A1 EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2014-04-24 US disclosed
US-20140113884-A1 EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2014-04-24 US disclosed
EP-2694470-A1 EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME M.C.W. Research Foundation, Inc. (US) 2014-02-12 EP disclosed
WO-2012138706-A1 EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME MCW RESEARCH FOUNDATION, INC. (US) 2012-10-11 WO disclosed
US-7732470-B2 Compositions and methods for the treatment of renal and cardiovascular disease MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE (US) 2010-06-08 US disclosed
EP-1315709-B1 AMINOALKYLBENZOYL-BENZOFURAN OR BENZOTHIOPHENE DERIVATIVES, METHOD FOR PREPARING SAME AND COMPOSITIONS CONTAINING SAME SANOFI AVENTIS (FR) 2010-05-26 EP disclosed
US-20080153889-A1 Compositions and Methods for the Treatment of Renal and Cardiovascular Disease MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE 2008-06-26 US disclosed
US-6949583-B2 Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method of preparing same and compositions containing same SANOFI-SYNTHELABO (FR) 2005-09-27 US disclosed
US-20030225100-A1 Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method of preparing same and compositions containing same SANOFI (FR) 2003-12-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080153889-A1 Compositions and Methods for the Treatment of Renal and Cardiovascular Disease REN, ALOX5, ALOX15B CYP3A4 715/4885SMYD2 2672/4885HTT 3120/4885
US-20170008918-A1 NOVEL CYP-EICOSANOID DERIVATIVES CYP4F3, ALOX5, CYP4A11 CYP3A4 65/4885SMYD2 4593/4885HTT 4867/4885
US-20030225100-A1 Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method of preparing same and compositions containing same NR2C2, NR4A2, NR5A2 CYP3A4 342/4885SMYD2 1600/4885HTT 3568/4885
US-20240041831-A1 20-HETE RECEPTOR (GPR75) ANTAGONISTS AND METHODS OF USE GPR55, GPR65, GPR35 CYP3A4 3658/4885SMYD2 4633/4885HTT 362/4885
US-20180104220-A1 IMIDAZOLE COMPOUND MAPT, SLC10A2, SLC5A11 CYP3A4 42/4885SMYD2 3771/4885HTT 1232/4885
US-20140113884-A1 EPOXYEICOSATRIENOIC ACID ANALOGS AND METHODS OF MAKING AND USING THE SAME PTGER1, PTGES, PTGER2 CYP3A4 190/4885SMYD2 3726/4885HTT 3423/4885
US-20250032453-A1 20-HETE RECEPTOR (GPR75) ANTAGONISTS AND METHODS OF USE GPR55, GPR65, GPR35 CYP3A4 3658/4885SMYD2 4633/4885HTT 362/4885
US-20200030291-A1 20-HETE RECEPTOR (GPR75) ANTAGONISTS AND METHODS OF USE GPR55, GPR65, GPR35 CYP3A4 3658/4885SMYD2 4633/4885HTT 362/4885
US-11690825-B2 20-HETE receptor (GPR75) antagonists and methods of use GPR55, GPR65, GPR35 CYP3A4 3658/4885SMYD2 4633/4885HTT 362/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.