Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 5/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | HTR2B | P41595 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3613788 | 0.95 | IDO1 (0.55) | IDO1LMNAALDH1A1GAAMAPT | |
| SCHEMBL29671027 | 0.95 | IDO1 (0.55) | IDO1LMNAALDH1A1GAAMAPT | |
| SCHEMBL19760706 | 0.90 | IDO1 (0.59) | IDO1LMNAALDH1A1GAAMAPT | |
| SCHEMBL29611992 | 0.90 | IDO1 (0.59) | IDO1LMNAALDH1A1GAAMAPT | |
| SCHEMBL28104371 | 0.85 | IDO1 (0.54) | IDO1LMNAALDH1A1GAAMAPT | |
| SCHEMBL1047831 | 0.81 | ALDH1A1 (0.66) | IDO1LMNAALDH1A1GAAMAPT | |
| SCHEMBL27825820 | 0.80 | IDO1 (0.58) | IDO1LMNAALDH1A1GAAMAPT | |
| SCHEMBL3262533 | 0.80 | IDO1 (0.51) | IDO1LMNAALDH1A1GAAMAPT | |
| SCHEMBL3263494 | 0.78 | IDO1 (0.52) | IDO1LMNAALDH1A1GAAMAPT | |
| SCHEMBL3239353 | 0.78 | IDO1 (0.52) | IDO1LMNAALDH1A1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108864080-B | Tetracyclic compounds as selective estrogen receptor down-regulating agents and application thereof | 南京圣和药业股份有限公司 | 2021-10-15 | — | — | CN | disclosed |
| WO-2010015587-A1 | 5-BENZYL-1,2,3,6-TETRAHYDRO-4,6-DIAZA-CYCLOPENTA[C]FLUORENE COMPOUNDS AND 5-BENZYL-1,2,3,6-TETRAHYDRO-4,6-DIAZA-CYCLOHEPTA[C]FLUORENE COMPOUNDS | NYCOMED GMBH (DE) | 2010-02-11 | — | — | WO | disclosed |
| US-7488751-B2 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan | WYETH (US) | 2009-02-10 | — | — | US | disclosed |
| US-20080139637-A1 | Catalyzed Reaction for Forming Indole-Based Compounds and Their Application in Anticancer Agents | NATIONAL TAIWAN NORMAL UNIVERSITY (TW) | 2008-06-12 | — | — | US | disclosed |
| US-20060160881-A1 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan | WYETH (US) | 2006-07-20 | — | — | US | disclosed |
| US-20060148881-A1 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-Benzodioxan | WYETH (US) | 2006-07-06 | — | — | US | disclosed |
| US-7041697-B2 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan | WYETH (US) | 2006-05-09 | — | — | US | disclosed |
| EP-1546151-B1 | ANTIDEPRESSANT CYCLOALKYLAMINE DERIVATIVES OF HETEROCYCLE-FUSED BENZODIOXANS | WYETH CORP (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6911445-B2 | For reatment of depression, childhood depression, dysthymia, anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder, attention deficit disorder, obsessive-compulsive disorder, cocaine and alcohol addiction | WYETH (US) | 2005-06-28 | — | — | US | disclosed |
| EP-1537103-A1 | ANTIDEPRESSANT CYCLOALKYLAMINE DERIVATES OF 2,3-DIHYDRO-1,4-BENZODIOXAN | Wyeth (US) | 2005-06-08 | — | — | EP | disclosed |
| US-20040171667-A1 | Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans | WYETH | 2004-09-02 | — | — | US | disclosed |
| US-20040127543-A1 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan | WYETH | 2004-07-01 | — | — | US | disclosed |
| WO-2004024723-A1 | ANTIDEPRESSANT CYCLOALKYLAMINE DERIVATIVES OF 2,3-DIHYDRO-1,4-BENZODIOXAN | WYETH (US) | 2004-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160881-A1 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan | HTR5A, OPRD1, DRD2 | IDO1 1320/4885LMNA 1619/4885ALDH1A1 273/4885 |
| US-20080139637-A1 | Catalyzed Reaction for Forming Indole-Based Compounds and Their Application in Anticancer Agents | IDO1, IDO2, HCCS | IDO1 1/4885LMNA 3467/4885ALDH1A1 35/4885 |
| US-20040127543-A1 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-benzodioxan | HTR5A, OPRD1, TAAR5 | IDO1 835/4885LMNA 1839/4885ALDH1A1 271/4885 |
| US-20060148881-A1 | Antidepressant cycloalkylamine derivatives of 2,3-dihydro-1,4-Benzodioxan | HTR5A, OPRD1, DRD2 | IDO1 1320/4885LMNA 1619/4885ALDH1A1 273/4885 |
| US-20040171667-A1 | Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans | HTR5A, CRH, TPH1 | IDO1 1805/4885LMNA 1501/4885ALDH1A1 664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.