Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 18/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 18/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 18/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 18/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 18/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 18/20 | 0.35 |
| ▸ | ACLY | P53396 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3298174 | 0.90 | ACLY (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3301093 | 0.89 | ACLY (0.32) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3300480 | 0.83 | PTGS2 (0.37) | ACLY | |
| SCHEMBL4432767 | 0.80 | KEAP1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3300362 | 0.79 | ACLY (0.32) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3299972 | 0.78 | PTGS2 (0.34) | — | |
| SCHEMBL3294496 | 0.77 | PTGS2 (0.34) | — | |
| SCHEMBL13390314 | 0.77 | PKM (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3300940 | 0.76 | HTR6 (0.41) | — | |
| SCHEMBL3297291 | 0.75 | ALDH1A1 (0.31) | ACLYITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100093703-A1 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093703-A1 | SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS | PYGL, PYGM, G6PC1 | PSEN1 167/4885PSEN2 628/4885APH1B 2811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.