Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | NOS1 | P29475 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.45 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | S100A4 | P26447 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methane SCHEMBL27952155 | 0.98 | TDP1 (0.52) | TDP1NOS1ALDH1A1PARP1KMT2A | |
| SCHEMBL11256062 | 0.76 | GRIN2D (0.50) | TDP1ALDH1A1KMT2AGRIN2DGRIN3B | |
| SCHEMBL18496993 | 0.75 | SIRT2 (0.41) | TDP1ALDH1A1PARP1KMT2AGRIN2D | |
| SCHEMBL28549 | 0.74 | ALDH1A1 (0.64) | TDP1NOS1ALDH1A1PARP1KMT2A | |
| SCHEMBL29471420 | 0.74 | ALDH1A1 (0.64) | TDP1NOS1ALDH1A1PARP1KMT2A | |
| SCHEMBL30265931 | 0.74 | TDP1 (0.52) | TDP1NOS1ALDH1A1PARP1KMT2A | |
| SCHEMBL29812003 | 0.74 | TDP1 (0.52) | TDP1NOS1ALDH1A1PARP1KMT2A | |
| SCHEMBL1002018 | 0.74 | TDP1 (0.52) | TDP1NOS1ALDH1A1PARP1KMT2A | |
| SCHEMBL12778290 | 0.74 | TDP1 (0.52) | TDP1NOS1ALDH1A1PARP1KMT2A | |
| SCHEMBL4524595 | 0.72 | ADORA3 (0.52) | TDP1NOS1ALDH1A1PARP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4583874-A1 | MULTITARGET NUCLEAR RECEPTOR LIGANDS BASED ON 2-(4-(QUINOLIN-2-YLOXY)PHENOXY)PROPANOIC ACID AND 2-(4-(QUINOXALIN-2-YLOXY)PHENOXY)PROPANOIC ACID FOR THE TREATMENT OF METABOLIC AND LIVER DISEASES | CHARLES UNIVERSITY, FACULTY OF PHARMACY IN HRADEC KRALOVE (CZ) | 2025-07-16 | — | — | EP | disclosed |
| WO-2024132001-A1 | MULTITARGET NUCLEAR RECEPTOR LIGANDS BASED ON 2-(4-(QUINOLIN-2-YLOXY)PHENOXY)PROPANOIC ACID AND 2-(4-(QUINOXALIN-2-YLOXY)PHENOXY)PROPANOIC ACID FOR THE TREATMENT OF METABOLIC AND LIVER DISEASES | CHARLES UNIVERSITY, FACULTY OF PHARMACY IN HRADEC KRALOVE (CZ) | 2024-06-27 | — | — | WO | disclosed |
| CN-111499622-B | Preparation method of medicine for treating bile duct cancer | 山东省科学院菏泽分院 | 2023-06-06 | — | — | CN | disclosed |
| CN-111499622-A | Preparation method of medicine for treating bile duct cancer | 山东省科学院菏泽分院 | 2020-08-07 | — | — | CN | disclosed |
| EP-2915804-B1 | NOVEL AMINE DERIVATIVE OR SALT THEREOF AS TNF ALPHA INHIBITORS | FUJIFILM TOYAMA CHEMICAL CO LTD (JP) | 2019-03-27 | — | — | EP | disclosed |
| US-9624215-B2 | Amine derivative or salt thereof | TOYAMA CHEMICAL CO., LTD. (JP) | 2017-04-18 | — | — | US | disclosed |
| US-9624215-B2 | Amine derivative or salt thereof | TOYAMA CHEMICAL CO., LTD. (JP) | 2017-04-18 | — | — | US | disclosed |
| US-9624215-B2 | Amine derivative or salt thereof | TOYAMA CHEMICAL CO., LTD. (JP) | 2017-04-18 | — | — | US | disclosed |
| US-20150299189-A1 | NOVEL AMINE DERIVATIVE OR SALT THEREOF | TOYAMA CHEMICAL CO., LTD. (JP) | 2015-10-22 | — | — | US | disclosed |
| US-20150299189-A1 | NOVEL AMINE DERIVATIVE OR SALT THEREOF | TOYAMA CHEMICAL CO., LTD. (JP) | 2015-10-22 | — | — | US | disclosed |
| CN-1225466-C | Sodium-hydrogen exchangertype 1 inhibitor (NHE-1) | PFIZER PROD INC (US) | 2005-11-02 | — | — | CN | disclosed |
| US-20050222154-A1 | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2005-10-06 | — | — | US | disclosed |
| US-20050209324-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2005-09-22 | — | — | US | disclosed |
| US-20050171109-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2005-08-04 | — | — | US | disclosed |
| US-20050131226-A1 | Rearranged pentanols, a process for their production and their use as anti-inflammatory agents | SCHERING AG (DE) | 2005-06-16 | — | — | US | disclosed |
| US-6852733-B2 | Sodium-hydrogen exchanger type 1 inhibitor | PFIZER INC. (US) | 2005-02-08 | — | — | US | disclosed |
| CN-1426404-A | Sodium-hydrogen exchanger type I (NHE-1) inhibitors | PFIZER PROD INC (US) | 2003-06-25 | — | — | CN | disclosed |
| EP-1276737-A1 | SODIUM-HYDROGEN EXCHANGER TYPE 1 INHIBITOR (NHE-1) | Pfizer Products Inc. (US) | 2003-01-22 | — | — | EP | disclosed |
| US-20010051634-A1 | Sodium-hydrogen exchanger type 1 inhibitor | CHEN WEICHAO G (US) | 2001-12-13 | — | — | US | disclosed |
| WO-2001083470-A1 | SODIUM-HYDROGEN EXCHANGER TYPE 1 INHIBITOR (NHE-1) | PFIZER PRODUCTS INC. (US) | 2001-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010051634-A1 | Sodium-hydrogen exchanger type 1 inhibitor | NHERF1, SLC9A1, SLC9A2 | TDP1 834/4885NOS1 264/4885ALDH1A1 838/4885 |
| US-20050171109-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | TNF, DHPS, PTGES | TDP1 2179/4885NOS1 51/4885ALDH1A1 511/4885 |
| US-20050222154-A1 | Multiply-substituted tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | DHPS, TNF, IL1B | TDP1 2818/4885NOS1 82/4885ALDH1A1 261/4885 |
| US-20150299189-A1 | NOVEL AMINE DERIVATIVE OR SALT THEREOF | HRH4, CLIC4, KRT18 | TDP1 4236/4885NOS1 64/4885ALDH1A1 1842/4885 |
| US-20050131226-A1 | Rearranged pentanols, a process for their production and their use as anti-inflammatory agents | TNF, PTGES, PTGES2 | TDP1 3643/4885NOS1 403/4885ALDH1A1 233/4885 |
| US-20050209324-A1 | Tetrahydronaphthalene derivatives, process for their production and their use as anti-inflammatory agents | TNF, DHPS, PTGES | TDP1 2179/4885NOS1 51/4885ALDH1A1 511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.