Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | IL1RN | P18510 | 1/20 | 0.54 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.54 |
| ▸ | ACP1 | P24666 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PTPRA | P18433 | 1/20 | 0.47 |
| ▸ | PTPRB | P23467 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 3/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL6746153 | 0.97 | CA2 (0.58) | CA2KEAP1CA1IL1RNERAP1 | |
| SCHEMBL146561 | 0.97 | CA2 (0.58) | CA2KEAP1CA1IL1RNERAP1 | |
| Hydrochloric Acid SCHEMBL5069950 | 0.95 | CA2 (0.56) | CA2KEAP1CA1IL1RNERAP1 | |
| SCHEMBL28176614 | 0.95 | CA2 (0.56) | CA2KEAP1CA1IL1RNERAP1 | |
| Ammonia Solution, Strong SCHEMBL4592850 | 0.95 | KEAP1 (0.56) | CA2KEAP1CA1IL1RNERAP1 | |
| SCHEMBL29756025 | 0.95 | CA2 (0.56) | CA2KEAP1CA1IL1RNERAP1 | |
| SCHEMBL3213812 | 0.95 | CA2 (0.56) | CA2KEAP1CA1IL1RNERAP1 | |
| Formaldehyde SCHEMBL28212330 | 0.93 | CA2 (0.54) | CA2KEAP1CA1IL1RNERAP1 | |
| Sulfamate SCHEMBL11079904 | 0.91 | CA1 (0.64) | CA2KEAP1CA1IL1RNERAP1 | |
| Chloromethane SCHEMBL11386742 | 0.91 | KEAP1 (0.58) | CA2KEAP1CA1IL1RNERAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080096830-A1 | Anti-Inflammatory Macrolide Conjugates | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2008-04-24 | — | — | US | claimed |
| EP-1844053-A2 | ANTI-INFLAMMATORY MACROLIDE CONJUGATES | GlaxoSmithKline istrazivacki centar Zagreb d.o.o. (HR) | 2007-10-17 | — | — | EP | claimed |
| WO-2006075255-A2 | ANTI-INFLAMATORY MACROLIDE CONJUGATES | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2006-07-20 | — | — | WO | claimed |
| US-11666584-B2 | Steroidal hormones for the treatment and prevention of wave burst arrhythmia | Assistance Publique—Hopitaux de Paris (FR) | 2023-06-06 | — | — | US | disclosed |
| US-20220387561-A1 | TREATMENT OF SEVERE ACUTE RESPIRATORY SYNDROME-RELATED CORONAVIRUS INFECTION WITH KLOTHO | COSTA RICAN SOCIAL SECURITY FUND / CAJA COSTARRICENSE DE SEGURO SOCIAL CCSS (CR) | 2022-12-08 | — | — | US | disclosed |
| WO-2022008971-A2 | TREATMENT OF SEVERE ACUTE RESPIRATORY SYNDROME-RELATED CORONAVIRUS INFECTION WITH KLOTHO | Costa Rican Social Security Fund / Caja Costarricense de Seguro Social (CCSS) (CR) | 2022-01-13 | — | — | WO | disclosed |
| US-20220008519-A1 | TREATMENT OF SEVERE ACUTE RESPIRATORY SYNDROME-RELATED CORONAVIRUS INFECTION WITH KLOTHO | Costa Rican Social Security Fund / Caja Costarricense de Seguro Social (CCSS) (CR) | 2022-01-13 | — | — | US | disclosed |
| US-20210346495-A1 | METHODS AND COMPOSITIONS COMPRISING AN NFKB INHIBITOR AND AN ADJUVANT | THE UNIVERSITY OF CHICAGO (US) | 2021-11-11 | — | — | US | disclosed |
| US-11071488-B2 | Method for determining the likelihood of torsades de pointes being induced | Assistance Publique—Hopitaux de Paris (FR) | 2021-07-27 | — | — | US | disclosed |
| US-20200352960-A1 | STEROIDAL HORMONES FOR THE TREATMENT AND PREVENTION OF WAVE BURST ARRHYTHMIA | ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS (FR) | 2020-11-12 | — | — | US | disclosed |
| EP-3445371-B1 | STEROIDAL HORMONES FOR THE TREATMENT AND PREVENTION OF WAVE BURST ARRHYTHMIA | HOPITAUX PARIS ASSIST PUBLIQUE (FR) | 2020-06-03 | — | — | EP | disclosed |
| WO-2013138871-A1 | IMMUNOMODULATORY AGENT AND USES THEREFOR | THE UNIVERSITY OF QUEENSLAND (AU) | 2013-09-26 | — | — | WO | disclosed |
| CN-103143022-A | Ophthalmologic irrigation solutions and method | OMEROS CORP | 2013-06-12 | — | — | CN | disclosed |
| US-20100151000-A1 | COMPOSITIONS AND METHODS FOR MODULATING IMMUNE RESPONSES | THE UNIVERSITY OF QUEENSLAND (AU) | 2010-06-17 | — | — | US | disclosed |
| CN-101327325-A | Ophthalmologic irrigation solutions and method | OMEROS CORP (US) | 2008-12-24 | — | — | CN | disclosed |
| US-20080096830-A1 | Anti-Inflammatory Macrolide Conjugates | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2008-04-24 | — | — | US | disclosed |
| EP-1844053-A2 | ANTI-INFLAMMATORY MACROLIDE CONJUGATES | GlaxoSmithKline istrazivacki centar Zagreb d.o.o. (HR) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006075255-A2 | ANTI-INFLAMATORY MACROLIDE CONJUGATES | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2006-07-20 | — | — | WO | disclosed |
| US-20060024691-A1 | Novel pathways in the etiology of cancer | BUCK INSTITUTE FOR AGE RESEARCH | 2006-02-02 | — | — | US | disclosed |
| CN-1684701-A | Ophthalmic irrigating solutions and methods | OMEROS CORP (US) | 2005-10-19 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200352960-A1 | STEROIDAL HORMONES FOR THE TREATMENT AND PREVENTION OF WAVE BURST ARRHYTHMIA | SHBG, NR5A1, HSD17B11 | CA2 3607/4885KEAP1 4011/4885CA1 2747/4885 |
| US-20210346495-A1 | METHODS AND COMPOSITIONS COMPRISING AN NFKB INHIBITOR AND AN ADJUVANT | NFKBIA, IKBKG, NFKB2 | CA2 3194/4885KEAP1 965/4885CA1 3706/4885 |
| US-20080096830-A1 | Anti-Inflammatory Macrolide Conjugates | NLRP3, IL1B, MPO | CA2 2929/4885KEAP1 2224/4885CA1 3472/4885 |
| US-11666584-B2 | Steroidal hormones for the treatment and prevention of wave burst arrhythmia | SHBG, NR5A1, HSD17B11 | CA2 3607/4885KEAP1 4011/4885CA1 2747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.