Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5679231 | 0.78 | RAB9A (0.39) | RAB9ASMN1; SMN2LMNANPC1PDE4B | |
| SCHEMBL21703665 | 0.77 | LMNA (0.38) | RAB9ASMN1; SMN2LMNANPC1PDE4B | |
| SCHEMBL20206959 | 0.71 | RAB9A (0.33) | RAB9ASMN1; SMN2LMNANPC1 | |
| SCHEMBL3165004 | 0.69 | SMN1; SMN2 (0.51) | RAB9ASMN1; SMN2LMNANPC1PDE4B | |
| SCHEMBL138271 | 0.69 | — | — | |
| SCHEMBL1092516 | 0.65 | — | — | |
| SCHEMBL17808532 | 0.64 | KCNH2 (0.31) | KCNH2 | |
| SCHEMBL3186703 | 0.64 | SMN1; SMN2 (0.38) | RAB9ASMN1; SMN2LMNANPC1PDE4B | |
| SCHEMBL12190580 | 0.64 | — | — | |
| SCHEMBL13938473 | 0.62 | NPC1 (0.46) | RAB9ASMN1; SMN2LMNANPC1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210198252-A1 | SMYD INHIBITORS | EPIZYME INC (US) | 2021-07-01 | — | — | US | disclosed |
| US-20200048195-A1 | SUBSTITUTED PYRROLIDINE CARBOXAMIDE COMPOUNDS | Epizyme, Inc. | 2020-02-13 | — | — | US | disclosed |
| US-20190322660-A1 | SMYD INHIBITORS | Epizyme, Inc. | 2019-10-24 | — | — | US | disclosed |
| US-20170355695-A1 | SMYD Inhibitors | Epizyme, Inc. (US) | 2017-12-14 | — | — | US | disclosed |
| US-20170247326-A1 | Substituted Pyrrolidine Carboxamide Compounds | Epizyme, Inc. (US) | 2017-08-31 | — | — | US | disclosed |
| US-20170247326-A1 | Substituted Pyrrolidine Carboxamide Compounds | Epizyme, Inc. (US) | 2017-08-31 | — | — | US | disclosed |
| US-20160194299-A1 | COMPOUNDS FOR TREATMENT OF DRUG RESISTANT AND PERSISTENT TUBERCULOSIS | THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH | 2016-07-07 | — | — | US | disclosed |
| US-8399381-B2 | Condensed heterocyclic sulfonyl urea compound, a herbicide containing the same, and a method for weed control using the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-03-19 | — | — | US | disclosed |
| US-8399381-B2 | Condensed heterocyclic sulfonyl urea compound, a herbicide containing the same, and a method for weed control using the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-03-19 | — | — | US | disclosed |
| US-8399381-B2 | Condensed heterocyclic sulfonyl urea compound, a herbicide containing the same, and a method for weed control using the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-03-19 | — | — | US | disclosed |
| US-20100160163-A1 | Fused heterocyclic sulfonylurea compound, herbicide containing the same, and method for controlling weed with the same | TANAKA YASUSHI | 2010-06-24 | — | — | US | disclosed |
| US-7544694-B2 | Substituted diaza-spiro-[5.5]-undecane derivatives and their use as neurokinin antagonists | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-06-09 | — | — | US | disclosed |
| US-20090062266-A1 | OXAZOLIDINONE COMPOUNDS, AND COMPOSITIONS AND METHODS RELATED THERETO | FERRER INTERNACIONAL, S.A. (ES) | 2009-03-05 | — | — | US | disclosed |
| EP-1466527-B1 | FUSED HETEROCYCLIC SULFONYLUREA COMPOUND, HERBICIDE CONTAINING THE SAME, AND METHOD OF CONTROLLING WEED WITH THE SAME | SUMITOMO CHEMICAL CO (JP) | 2008-07-16 | — | — | EP | disclosed |
| EP-1466527-B1 | FUSED HETEROCYCLIC SULFONYLUREA COMPOUND, HERBICIDE CONTAINING THE SAME, AND METHOD OF CONTROLLING WEED WITH THE SAME | SUMITOMO CHEMICAL CO (JP) | 2008-07-16 | — | — | EP | disclosed |
| CN-100349517-C | Fused heterocyclic sulfonylurea compound, herbicide containing the same and method of controlling weed with the same | SUMITOMO CHEM TAKEDA AGRO CO (JP) | 2007-11-21 | — | — | CN | disclosed |
| US-20070232636-A1 | Substituted Diaza-Spiro-[5.5]-Undecane Derivaties and Their Use as Neurokinin Antagonists | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-04 | — | — | US | disclosed |
| CN-1617666-A | Fused heterocyclic sulfonylurea compound, herbicide containing the same, and method for controlling weeds using the same | SUMITOMO CHEM TAKEDA AGRO CO (JP) | 2005-05-18 | — | — | CN | disclosed |
| US-20050032650-A1 | Fused heterocyclic sulfonylurea compound herbicide containing the same and method of controlling weed with the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2005-02-10 | — | — | US | disclosed |
| EP-1466527-A1 | FUSED HETEROCYCLIC SULFONYLUREA COMPOUND, HERBICIDE CONTAINING THE SAME, AND METHOD OF CONTROLLING WEED WITH THE SAME | Sumitomo Chemical Takeda Agro Company, Limited (JP) | 2004-10-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062266-A1 | OXAZOLIDINONE COMPOUNDS, AND COMPOSITIONS AND METHODS RELATED THERETO | MAOA, MAOB, AOC2 | RAB9A 1640/4885SMN1; SMN2 1819/4885LMNA 4540/4885 |
| US-20100160163-A1 | Fused heterocyclic sulfonylurea compound, herbicide containing the same, and method for controlling weed with the same | NOTUM, WEE1, DDT | RAB9A 1275/4885SMN1; SMN2 3839/4885LMNA 3500/4885 |
| US-20070232636-A1 | Substituted Diaza-Spiro-[5.5]-Undecane Derivaties and Their Use as Neurokinin Antagonists | NPSR1, PROKR2, KISS1R | RAB9A 2247/4885SMN1; SMN2 493/4885LMNA 931/4885 |
| US-20170355695-A1 | SMYD Inhibitors | SMYD3, SMYD2, SMURF2 | RAB9A 893/4885SMN1; SMN2 253/4885LMNA 4437/4885 |
| US-20210198252-A1 | SMYD INHIBITORS | SMYD3, SMYD2, SMURF2 | RAB9A 890/4885SMN1; SMN2 249/4885LMNA 4418/4885 |
| US-20160194299-A1 | COMPOUNDS FOR TREATMENT OF DRUG RESISTANT AND PERSISTENT TUBERCULOSIS | FNTB, PGLS, EP300 | RAB9A 1274/4885SMN1; SMN2 4883/4885LMNA 2060/4885 |
| US-20170247326-A1 | Substituted Pyrrolidine Carboxamide Compounds | SMYD3, SMYD2, SMURF2 | RAB9A 447/4885SMN1; SMN2 122/4885LMNA 4434/4885 |
| US-20190322660-A1 | SMYD INHIBITORS | SMYD2, SMYD3, SMURF2 | RAB9A 736/4885SMN1; SMN2 191/4885LMNA 4699/4885 |
| US-20050032650-A1 | Fused heterocyclic sulfonylurea compound herbicide containing the same and method of controlling weed with the same | NOTUM, WEE1, DDT | RAB9A 1361/4885SMN1; SMN2 3664/4885LMNA 3357/4885 |
| US-20200048195-A1 | SUBSTITUTED PYRROLIDINE CARBOXAMIDE COMPOUNDS | SMYD3, SMYD2, SMURF2 | RAB9A 447/4885SMN1; SMN2 122/4885LMNA 4434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.