Sugi Predict

Sugi Predict / Compounds / SCHEMBL3351697

SCHEMBL3351697

SCHEMBL3351697

C[Si](C)(C)C#Cc1cccc(CO)c1

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ FFAR1 O14842 2/20 0.48
▸ PRKCI P41743 1/20 0.40
▸ ENPP2 Q13822 1/20 0.39
▸ GRM5 P41594 2/20 0.38
▸ PRSS1 P07477 1/20 0.37
▸ PRSS2 P07478 1/20 0.37
▸ PRSS3 P35030 1/20 0.37
▸ NOS3 P29474 2/20 0.36
▸ NOS1 P29475 2/20 0.36
▸ NOS2 P35228 2/20 0.36
▸ TSHR P16473 1/20 0.35
▸ CYP11B1 P15538 1/20 0.35
▸ CYP11B2 P19099 1/20 0.35
▸ CYP2D6 P10635 3/20 0.35
▸ HRH3 Q9Y5N1 3/20 0.35
▸ HRH4 Q9H3N8 1/20 0.35
▸ CHRNB4 P30926 1/20 0.34
▸ CHRNA3 P32297 1/20 0.34
▸ CHRNA7 P36544 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2797815 0.84 GRM5 (0.38) GRM5CYP2D6HRH3HRH4
SCHEMBL24969103 0.82 GRM5 (0.38) GRM5TSHRCYP2D6HRH3HRH4
SCHEMBL3446231 0.81 FFAR1 (0.49) FFAR1TSHR
SCHEMBL8850812 0.81 HRH3 (0.47) GRM5PRSS1PRSS2PRSS3CYP2D6
SCHEMBL19440746 0.81 CYP2D6 (0.39) FFAR1GRM5CYP2D6HRH3HRH4
SCHEMBL3614755 0.80 GRM5 (0.39) GRM5CYP2D6
SCHEMBL14860188 0.80 EPHX1 (0.37) FFAR1GRM5NOS3NOS1NOS2
SCHEMBL8769066 0.79 FFAR1 (0.51) FFAR1PRKCIENPP2GRM5PRSS1
SCHEMBL19442429 0.79 PRMT6 (0.45) GRM5NOS3NOS1NOS2CYP2D6
SCHEMBL3353828 0.79 GRM5 (0.51) FFAR1GRM5CYP2D6HRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260007672-A1 INHIBITORS OF MPTP NRG THERAPEUTICS LTD (GB) 2026-01-08 — — US disclosed
US-12491185-B2 Inhibitors of mPTP NRG THERAPEUTICS LTD (GB) 2025-12-09 — — US disclosed
EP-4652162-A1 INHIBITORS OF MPTP NRG Therapeutics LTD (GB) 2025-11-26 — — EP disclosed
US-20250177397-A1 INHIBITORS OF MPTP NRG THERAPEUTICS LTD (GB) 2025-06-05 — — US disclosed
WO-2024153946-A1 INHIBITORS OF MPTP NRG THERAPEUTICS LTD (GB) 2024-07-25 — — WO disclosed
US-11787877-B2 Antibody with non-natural amino acid introduced therein RIKEN (JP) 2023-10-17 — — US disclosed
US-11725000-B2 Apoptosis inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2023-08-15 — — US disclosed
US-20230115350-A1 TEAD INHIBITORS AND USES THEREOF CEDILLA THERAPEUTICS, INC. 2023-04-13 — — US disclosed
WO-2023009785-A1 TEAD INHIBITORS AND USES THEREOF CEDILLA THERAPEUTICS, INC. (US) 2023-02-02 — — WO disclosed
WO-2023009785-A1 TEAD INHIBITORS AND USES THEREOF CEDILLA THERAPEUTICS, INC. (US) 2023-02-02 — — WO disclosed
CN-110023292-B Apoptosis inhibitors 北京生命科学研究所 2022-10-04 — — CN disclosed
US-20210309647-A1 Apoptosis Inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2021-10-07 — — US disclosed
US-11034680-B2 Apoptosis inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2021-06-15 — — US disclosed
US-20210107997-A1 ANTIBODY WITH NON-NATURAL AMINO ACID INTRODUCED THEREIN RIKEN (JP) 2021-04-15 — — US disclosed
US-10906990-B2 Antibody with non-natural amino acid introduced therein RIKEN (JP) 2021-02-02 — — US disclosed
EP-3484854-B1 APOPTOSIS INHIBITORS NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING (CN) 2021-01-20 — — EP disclosed
CN-110023292-A Apoptosis inhibitor 北京生命科学研究所 2019-07-16 — — CN disclosed
US-20190152960-A1 Apoptosis Inhibitors NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2019-05-23 — — US disclosed
US-20190127488-A1 ANTIBODY WITH NON-NATURAL AMINO ACID INTRODUCED THEREIN RIKEN (JP) 2019-05-02 — — US disclosed
WO-2010063487-A1 PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE MERZ PHARMA GMBH & CO. KGAA (DE) 2010-06-10 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190152960-A1 Apoptosis Inhibitors BAX, SDHA, SDHB FFAR1 4069/4885PRKCI 2208/4885ENPP2 3156/4885
US-11725000-B2 Apoptosis inhibitors BAX, SDHA, SDHB FFAR1 4069/4885PRKCI 2208/4885ENPP2 3156/4885
US-20230115350-A1 TEAD INHIBITORS AND USES THEREOF TEAD2, TEAD3, TEAD4 FFAR1 4430/4885PRKCI 2385/4885ENPP2 2916/4885
US-12491185-B2 Inhibitors of mPTP PARK7, PINK1, SNCA FFAR1 2119/4885PRKCI 3501/4885ENPP2 464/4885
US-20190127488-A1 ANTIBODY WITH NON-NATURAL AMINO ACID INTRODUCED THEREIN NSUN3, NSUN2, LNPEP FFAR1 3776/4885PRKCI 2865/4885ENPP2 3777/4885
US-10906990-B2 Antibody with non-natural amino acid introduced therein NSUN3, NSUN2, LNPEP FFAR1 3776/4885PRKCI 2865/4885ENPP2 3777/4885
US-20250177397-A1 INHIBITORS OF MPTP PARK7, PINK1, SNCA FFAR1 2119/4885PRKCI 3501/4885ENPP2 464/4885
US-20210107997-A1 ANTIBODY WITH NON-NATURAL AMINO ACID INTRODUCED THEREIN NSUN3, NSUN2, LNPEP FFAR1 3776/4885PRKCI 2865/4885ENPP2 3777/4885
US-20260007672-A1 INHIBITORS OF MPTP PARK7, SNCA, CYC1 FFAR1 1465/4885PRKCI 3221/4885ENPP2 2998/4885
US-11787877-B2 Antibody with non-natural amino acid introduced therein NSUN3, NSUN2, LNPEP FFAR1 3776/4885PRKCI 2865/4885ENPP2 3777/4885
US-11034680-B2 Apoptosis inhibitors BAX, SDHA, SDHB FFAR1 4069/4885PRKCI 2208/4885ENPP2 3156/4885
US-20210309647-A1 Apoptosis Inhibitors BAX, SDHA, SDHB FFAR1 4069/4885PRKCI 2208/4885ENPP2 3156/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.