Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12367515 | 0.85 | SIRT2 (0.45) | HTR7ACHEHRH4SIRT6SIRT2 | |
| SCHEMBL3354596 | 0.79 | ACHE (0.48) | HTR7ACHEHRH4SIRT6ALDH1A1 | |
| SCHEMBL3353280 | 0.78 | HTR7 (0.53) | HTR7ACHEHRH4SIRT6HIF1A | |
| SCHEMBL8531640 | 0.78 | HTR2A (0.43) | ALDH1A1OPRM1OPRL1 | |
| SCHEMBL3353952 | 0.77 | KDM4E (0.41) | HRH4ALDH1A1OPRM1OPRL1MAPT | |
| SCHEMBL3356604 | 0.76 | HTR1A (0.52) | HTR7ACHEHRH4SIRT6HIF1A | |
| SCHEMBL3354240 | 0.75 | HTR7 (0.45) | HTR7ACHEHRH4SIRT6ALDH1A1 | |
| SCHEMBL3349648 | 0.75 | ACHE (0.41) | HTR7ACHESIRT6SIRT2ALDH1A1 | |
| SCHEMBL3356653 | 0.75 | LMNA (0.42) | HTR7ACHESIRT6SIRT2ALDH1A1 | |
| SCHEMBL10413622 | 0.74 | MAPT (0.51) | HTR7ACHEALDH1A1PKMNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |